Search Results - "Glasebrook, Andrew"

Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor by Iwata, Masaaki, Ota, Kristie T, Li, Xiao-Yuan, Sakaue, Fumika, Li, Nanxin, Dutheil, Sophie, Banasr, Mounira, Duric, Vanja, Yamanashi, Takehiko, Kaneko, Koichi, Rasmussen, Kurt, Glasebrook, Andrew, Koester, Anja, Song, Dekun, Jones, Kenneth A, Zorn, Stevin, Smagin, Gennady, Duman, Ronald S

“…Abstract Background The mechanisms underlying stress-induced inflammation that contribute to major depressive disorder are unknown. We examine the role of the…”
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A humanized CD3ε-knock-in mouse model for pre-clinical testing of anti-human CD3 therapy by Crespo, Joel, Koh, Yi Ting, Hu, Ningjie, Moore, Paul A, Bonvini, Ezio, Glasebrook, Andrew L, Martin, Andrea P, Benschop, Robert J

“…Pre-clinical murine models are critical for translating drug candidates from the bench to the bedside. There is interest in better understanding how anti-human…”
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Fab-based bispecific antibody formats with robust biophysical properties and biological activity by Wu, Xiufeng, Sereno, Arlene J, Huang, Flora, Lewis, Steven M, Lieu, Ricky L, Weldon, Caroline, Torres, Carina, Fine, Cody, Batt, Micheal A, Fitchett, Jonathan R, Glasebrook, Andrew L, Kuhlman, Brian, Demarest, Stephen J

“…A myriad of innovative bispecific antibody (BsAb) platforms have been reported. Most require significant protein engineering to be viable from a development…”
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Dichotomous impact of affinity on the function of T cell engaging bispecific antibodies by Poussin, Mathilde, Sereno, Arlene, Wu, Xiufeng, Huang, Flora, Manro, Jason, Cao, Shanshan, Carpenito, Carmine, Glasebrook, Andrew, Powell Jr, Daniel J, Demarest, Stephen

“…BackgroundBispecific T cell engagers represent the majority of bispecific antibodies (BsAbs) entering the clinic to treat metastatic cancer. The ability to…”
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Prevention and Treatment of Experimental Breast Cancer with the Combination of a New Selective Estrogen Receptor Modulator, Arzoxifene, and a New Rexinoid, LG 100268 by Suh, Nanjoo, Lamph, William W, Glasebrook, Andrew L, Grese, Timothy A, Palkowitz, Alan D, Williams, Charlotte R, Risingsong, Renee, Farris, M Rendi, Heyman, Richard A, Sporn, Michael B

“…The selective estrogen receptor modulator arzoxifene and the rexinoid LG 100268 were active not only as single agents for prevention and treatment of breast…”
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Arzoxifene, a new selective estrogen receptor modulator for chemoprevention of experimental breast cancer by NANJOO SUH, GLASEBROOK, Andrew L, SPORN, Michael B, PALKOWITZ, Alan D, BRYANT, Henry U, BURRIS, Lorris L, STARLING, James J, PEARCE, Homer L, WILLIAMS, Charlotte, PEER, Christopher, YONGPING WANG

“…Arzoxifene ([6-hydroxy-3-[4-[2-(1-piperidinyl)-ethoxy]phenoxy]-2-(4-methoxyphenyl)]benzo[b]thiophene) is a selective estrogen receptor modulator (SERM) that is…”
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Discovery and Synthesis of [6-Hydroxy-3-[4-[2-(1-piperidinyl)ethoxy]phenoxy]- 2-(4-hydroxyphenyl)]benzo[b]thiophene:  A Novel, Highly Potent, Selective Estrogen Receptor Modulator by Palkowitz, Alan D, Glasebrook, Andrew L, Thrasher, K. Jeff, Hauser, Kenneth L, Short, Lorri L, Phillips, D. Lynn, Muehl, Brian S, Sato, Masahiko, Shetler, Pamela K, Cullinan, George J, Pell, Tina R, Bryant, Henry U

“…Raloxifene, [2-(4-hydroxyphenyl)-6-hydroxybenzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone hydrochloride (2), is representative of a class of…”
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Structure−Activity Relationships of Selective Estrogen Receptor Modulators:  Modifications to the 2-Arylbenzothiophene Core of Raloxifene by Grese, Timothy A, Cho, Stephen, Finley, Don R, Godfrey, Alexander G, Jones, Charles D, Lugar, Charles W, Martin, Michael J, Matsumoto, Ken, Pennington, Lewis D, Winter, Mark A, Adrian, M. Dee, Cole, Harlan W, Magee, David E, Phillips, D. Lynn, Rowley, Ellen R, Short, Lorri L, Glasebrook, Andrew L, Bryant, Henry U

“…The 2-arylbenzothiophene raloxifene, 1, is a selective estrogen receptor modulator which is currently under clinical evaluation for the prevention and…”
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Resistance to Myelin Oligodendrocyte Glycoprotein-Induced Experimental Autoimmune Encephalomyelitis by Death Receptor 6-Deficient Mice by Schmidt, Clint S, Zhao, Jingyong, Chain, Jana, Hepburn, Deena, Gitter, Bruce, Sandusky, George, Chintalacharuvu, Subba, Glasebrook, Andrew, Na, Songqing

“…Genetic disruption of death receptor 6 (DR6) results in enhanced CD4+ T cell expansion, Th2 differentiation, and humoral responses after stimulation. However,…”
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Enhanced B cell expansion, survival, and humoral responses by targeting death receptor 6 by Schmidt, Clint S, Liu, Jinqi, Zhang, Tonghai, Song, Ho Yeong, Sandusky, George, Mintze, Karen, Benschop, Robert J, Glasebrook, Andrew, Yang, Derek D, Na, Songqing

“…Targeted disruption of death receptor (DR)6 results in enhanced CD4(+) T cell expansion and T helper cell type 2 differentiation after stimulation. Similar to…”
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LIGHT‐deficiency impairs CD8+ T cell expansion, but not effector function by Liu, Jinqi, Schmidt, Clint S., Zhao, Feisha, Okragly, Angela J., Glasebrook, Andrew, Fox, Niles, Galbreath, Elizabeth, Zhang, Qing, Song, Ho Yeong, Na, Songqing, Yang, Derek D.

“…LIGHT, a newly identified member of the tumor necrosis factor (TNF) family, is expressed on activated T lymphocytes. To evaluate how LIGHT contributes to T…”
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Molecular Determinants of Tissue Selectivity in Estrogen Receptor Modulators by Grese, Timothy A., Sluka, James P., Bryant, Henry U., Cullinan, George J., Glasebrook, Andrew L., Jones, Charles D., Matsumoto, Ken, Palkowitz, Alan D., Sato, Masahiko, Termine, John D., Winter, Mark A., Yang, Na N., Dodge, Jeffrey A.

“…Interaction of the estrogen receptor/ligand complex with a DNA estrogen response element is known to regulate gene transcription. In turn, specific…”
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An improved colorimetric assay for cell proliferation and viability utilizing the tetrazolium salt XTT by Roehm, N W, Rodgers, G H, Hatfield, S M, Glasebrook, A L

“…A new tetrazolium salt XTT, sodium 3'-[1-[(phenylamino)-carbonyl]-3,4-tetrazolium]-bis(4-methoxy-6- nitro)benzene-sulfonic acid hydrate, was evaluated for use…”
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Photochemical Synthesis of N-Arylbenzophenanthridine Selective Estrogen Receptor Modulators (SERMs) by Grese, Timothy A, Adrian, M. Dee, Phillips, D. Lynn, Shetler, Pamela K, Short, Lorri L, Glasebrook, Andrew L, Bryant, Henry U

“…Selective estrogen receptor modulators are an emerging class of pharmaceutically important molecules. Many compounds in this class contain an aminoethoxyaryl…”
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Activation of caspase‐3 alone is insufficient for apoptotic morphological changes in human neuroblastoma cells by Racke, Margaret M., Mosior, Marian, Kovacevic, Steve, Chang, Chan Hsin S., Glasebrook, Andrew L., Roehm, Neal W., Na, Songqing

“…Activated caspase‐3 is considered an important enzyme in the cell death pathway. To study the specific role of caspase‐3 activation in neuronal cells, we…”
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A pharmacological review of raloxifene by Bryant, Henry U., Glasebrook, Andrew L., Yang, Na N., Sato, Masahiko

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A humanized CD3[epsilon]-knock-in mouse model for pre-clinical testing of anti-human CD3 therapy by Crespo, Joel, Koh, Yi Ting, Hu, Ningjie, Moore, Paul A, Bonvini, Ezio, Glasebrook, Andrew L, Martin, Andrea P, Benschop, Robert J

“…Pre-clinical murine models are critical for translating drug candidates from the bench to the bedside. There is interest in better understanding how anti-human…”
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Molecular Insights into Fully Human and Humanized Monoclonal Antibodies: What are the Differences and Should Dermatologists Care? by Mallbris, Lotus, Davies, Julian, Glasebrook, Andrew, Tang, Ying, Glaesner, Wolfgang, Nickoloff, Brian J

“…In recent years, a large number of therapeutic monoclonal antibodies have come to market to treat a variety of conditions including patients with…”
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Hypocholesterolemic activity of raloxifene (LY139481): pharmacological characterization as a selective estrogen receptor modulator by Kauffman, R F, Bensch, W R, Roudebush, R E, Cole, H W, Bean, J S, Phillips, D L, Monroe, A, Cullinan, G J, Glasebrook, A L, Bryant, H U

“…After once-daily oral dosing in ovariectomized rats, raloxifene (LY139481) hydrochloride produced dose- and time-dependent reductions in serum cholesterol and…”
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Identification of an Estrogen Response Element Activated by Metabolites of 17β-Estradiol and Raloxifene by Yang, Na N., Venugopalan, Murali, Hardikar, Sushant, Glasebrook, Andrew

“…17β-Estradiol modulates gene transcription through the estrogen receptor and the estrogen response element in DNA. The human transforming growth factor-β3 gene…”
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