Search Results - "Glaros, Alexander K"
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A systematic literature review of frequency of vaso-occlusive crises in sickle cell disease
Published in Orphanet journal of rare diseases (02-11-2021)“…Abstract Background and purpose Sickle cell disease (SCD) is a collection of rare inherited blood disorders affecting approximately 100,000 people in the U.S…”
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Voxelotor: alteration of sickle cell disease pathophysiology by a first-in-class polymerization inhibitor
Published in Therapeutic Advances in Hematology (2021)“…Sickle cell disease, despite its recognition as a severely debilitating genetic condition affecting hundreds of thousands of neonates throughout the world each…”
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Targeting TRPV1 activity via high‐dose capsaicin in patients with sickle cell disease
Published in EJHaem (01-08-2022)“…Evidence suggests neuropathic pain (NP) develops over time in sickle cell disease (SCD), contributing to a complex, difficult‐to‐treat phenotype, with…”
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Voxelotor (GBT440) in pediatric sickle cell disease: A review
Published in Pediatric hematology oncology journal (01-12-2024)“…Sickle cell disease (SCD) was first described in 1910 in African Americans, and the mutant hemoglobin S (HbS) was identified by electrophoresis in 1948. Sickle…”
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Prophylactic Hydroxyurea Treatment Is Associated with Improved Cerebral Hemodynamics as a Surrogate Marker of Stroke Risk in Sickle Cell Disease: A Retrospective Comparative Analysis
Published in Journal of clinical medicine (17-06-2022)“…Sickle cell disease (SCD) increases the incidence of childhood stroke eighty-fold. Stroke risk can be estimated by measurement of the blood velocity through…”
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Navigating a new terrain: how Twitter is changing hematologists
Published in Blood advances (12-01-2021)Get full text
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My Two Teachers
Published in Journal of Sickle Cell Disease (07-11-2024)“…He was a Warrior. Every breath was his battlefield…”
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Burden of Illness of Alpha- and Beta-Thalassemia: A Qualitative Study
Published in Blood (02-11-2023)“…Alpha (α)- and beta (β)-thalassemia are inherited red blood cell disorders with a wide spectrum of symptoms, functional manifestations, and disease burden. The…”
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Smaart Criz: Sickle Cell Mechanisms of Activation, Adhesion, Rheology, and Thrombosis (SMAART) in Response to P-Selectin Inhibition
Published in Blood (02-11-2023)“…Sickle cell disease (SCD) pathophysiology involves uncontrolled inflammation, dysregulated coagulation, and adherence of erythrocytes, leukocytes, and…”
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A Phase 2/3, Double-Blind, Randomized, Placebo-Controlled, Multicenter Study of Mitapivat in Patients with Sickle Cell Disease: RISE UP Phase 2 Results
Published in Blood (02-11-2023)“…Background: Sickle cell disease (SCD) is characterized by the presence of hemoglobin S (HbS), a structural variant caused by a mutation in the HBB gene…”
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