Search Results - "Glancey, M J"

Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics by FORRESTER, L. M, HENDERSON, C. J, WOLF, C. R, GLANCEY, M. J, BACK, D. J, PARK, B. K, BALL, S. E, KITTERINGHAM, N. R, MCLAREN, A. W, MILES, J. S, SKETT, P

“…Cytochrome P450s play a central role in the metabolism and disposition of an extremely wide range of drugs and chemical carcinogens. Individual differences in…”
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Glutathione S-transferase and glutathione peroxidase expression in normal and tumour human tissues by Howie, A F, Forrester, L M, Glancey, M J, Schlager, J J, Powis, G, Beckett, G J, Hayes, J D, Wolf, C R

“…Glutathione S-transferases play a central role in drug detoxification and have been implicated in the sensitivity of tumour cells to anticancer drugs. In this…”
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Evidence for involvement of multiple forms of cytochrome P-450 in aflatoxin B1 metabolism in human liver by FORRESTER, L. M, NEAL, G. E, JUDAH, D. J, GLANCEY, M. J, WOLF, C. R

“…Liver cancer is a major cause of premature death in many areas of Africa and Asia and its incidence is strongly correlated with exposure to aflatoxin B1…”
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Identification of the human liver cytochrome P-450 responsible for coumarin 7-hydroxylase activity by Miles, J S, McLaren, A W, Forrester, L M, Glancey, M J, Lang, M A, Wolf, C R

“…1. We have constructed a full-length human liver cytochrome P450IIA cDNA from a partial-length clone by oligonucleotide-directed mutagenesis, and subcloned it…”
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Increased mutagenicity of 1,2-dibromo-3-chloropropane and tris(2,3-dibromopropyl)phosphate in Salmonella TA100 expressing human glutathione S-transferases by Simula, T P, Glancey, M J, Söderlund, E J, Dybing, E, Wolf, C R

“…We have expressed human glutathione S-transferases GSTA1-1 and GSTP1-1 in Salmonella typhimurium TA100 in order to assess the ability of these enzymes to…”
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Human glutathione S-transferase-expressing Salmonella typhimurium tester strains to study the activation/detoxification of mutagenic compounds: studies with halogenated compounds, aromatic amines and aflatoxin B1 by Simula, T P, Glancey, M J, Wolf, C R

“…We have developed Salmonella typhimurium strains expressing human glutathione S-transferases (GSTs) to establish the role of these enzymes in chemical…”
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Functional co-expression of CYP2D6 and human NADPH-cytochrome P450 reductase in Escherichia coli by Pritchard, M P, Glancey, M J, Blake, J A, Gilham, D E, Burchell, B, Wolf, C R, Friedberg, T

“…The polymorphic human CYP2D6 has been co-expressed with human NADPH-cytochrome P450 oxidoreductase in Escherichia coli in order to generate a functional…”
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Relative expression of cytochrome P 450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics by Forrester, L M, Henderson, C J, Glancey, M J, Back, D J, Park, B K, Ball, S E, Kitteringham, N R, McLaren, A W, Miles, J S, Skett, P, Wolf, C R

“…Cytochrome P450s play a central role in the metabolism and disposition of an extremely wide range of drugs and chemical carcinogens. Individual differences in…”
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Evidence for involvement of multiple forms of cytochrome P-450 in aflatoxin B sub(1) metabolism in human liver by rester, L M, Neal, GE, Judah, D J, Glancey, MJ, Wolf, C R

“…Liver cancer is a major cause of premature death in many areas of Africa and Asia and its incidence is strongly correlated with exposure to aflatoxin B sub(1)…”
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