Search Results - "Glaenzel, Ulrike"

Metabolism and Disposition of Siponimod, a Novel Selective S1P1/S1P5 Agonist, in Healthy Volunteers and In Vitro Identification of Human Cytochrome P450 Enzymes Involved in Its Oxidative Metabolism by Glaenzel, Ulrike, Jin, Yi, Nufer, Robert, Li, Wenkui, Schroer, Kirsten, Adam-Stitah, Sylvie, van Marle, Sjoerd Peter, Legangneux, Eric, Borell, Hubert, James, Alexander D, Meissner, Axel, Camenisch, Gian, Gardin, Anne

“…Siponimod, a next-generation selective sphingosine-1-phosphate receptor modulator, is currently being investigated for the treatment of secondary progressive…”
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Drug–drug interactions of icenticaftor (QBW251) with a 5‐probe cytochrome P450 cocktail and oral contraceptives by Huth, Felix, Glaenzel, Ulrike, Drollmann, Anton, Weis, Wendy, Zack, Julia, Bebrevska, Lidiya

“…A drug–drug interaction (DDI) study was conducted to evaluate the effect of icenticaftor (QBW251) on the pharmacokinetics (PK) of a 5‐probe cytochrome P450…”
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Absorption, Distribution, Metabolism, and Elimination of the Direct Renin Inhibitor Aliskiren in Healthy Volunteers by WALDMEIER, Felix, GLAENZEL, Ulrike, WIRZ, Bernard, OBERER, Lukas, SCHMID, Dietmar, SEIBERLING, Michael, VALENCIA, Jessica, RIVIERE, Gilles-Jacques, END, Peter, VAIDYANATHAN, Sujata

“…Aliskiren (2( S ),4( S ),5( S ),7( S )- N -(2-carbamoyl-2-methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3-methoxypropoxy)phenyl]-octanamid…”
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An integrated assessment of the ADME properties of the CDK4/6 Inhibitor ribociclib utilizing preclinical in vitro, in vivo, and human ADME data by James, Alexander D., Schiller, Hilmar, Marvalin, Cyrille, Jin, Yi, Borell, Hubert, Roffel, Ad F., Glaenzel, Ulrike, Ji, Yan, Camenisch, Gian

“…Ribociclib (LEE011, Kisqali ®) is a highly selective small molecule inhibitor of cyclin‐dependent kinases 4 and 6 (CDK4/6), which has been approved for the…”
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Absorption, Distribution, Metabolism, and Excretion of Icenticaftor (QBW251) in Healthy Male Volunteers at Steady State and In Vitro Phenotyping of Major Metabolites by Glaenzel, Ulrike, Huth, Felix, Eggimann, Fabian, Hackling, Melissa, Leuthold, Luc Alexis, Meissner, Axel, Bebrevska, Lidiya

“…Icenticaftor (QBW251) is a potentiator of the CFTR protein and is currently in clinical development for the treatment of chronic obstructive pulmonary disease…”
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PIMECROLIMUS: ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION IN HEALTHY VOLUNTEERS AFTER A SINGLE ORAL DOSE AND SUPPLEMENTARY INVESTIGATIONS IN VITRO by ZOLLINGER, Markus, WALDMEIER, Felix, GRASSBERGER, Maximilian A, HARTMANN, Stefan, ZENKE, Gerhard, ZIMMERLIN, Alfred G, GLAENZEL, Ulrike, BALDECK, Jean-Pierre, SCHWEITZER, Alain, BERTHIER, Stephane, MOENIUS, Thomas

“…The absorption and disposition of pimecrolimus, a calcineurin inhibitor developed for the treatment of inflammatory skin diseases, was investigated in four…”
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Absorption, Distribution, Metabolism, and Excretion of Capmatinib (INC280) in Healthy Male Volunteers and In Vitro Aldehyde Oxidase Phenotyping of the Major Metabolite by Glaenzel, Ulrike, Jin, Yi, Hansen, Regine, Schroer, Kirsten, Rahmanzadeh, Gholamreza, Pfaar, Ulrike, Jaap van Lier, Jan, Borell, Hubert, Meissner, Axel, Camenisch, Gian, Zhao, Sylvia

“…Capmatinib (INC280), a highly selective and potent inhibitor of the MET receptor tyrosine kinase, has demonstrated clinically meaningful efficacy and a…”
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Discovery of Icenticaftor (QBW251), a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator with Clinical Efficacy in Cystic Fibrosis and Chronic Obstructive Pulmonary Disease by Grand, Darren Le, Gosling, Martin, Baettig, Urs, Bahra, Parmjit, Bala, Kamlesh, Brocklehurst, Cara, Budd, Emma, Butler, Rebecca, Cheung, Atwood K, Choudhury, Hedaythul, Collingwood, Stephen P, Cox, Brian, Danahay, Henry, Edwards, Lee, Everatt, Brian, Glaenzel, Ulrike, Glotin, Anne-Lise, Groot-Kormelink, Paul, Hall, Edward, Hatto, Julia, Howsham, Catherine, Hughes, Glyn, King, Anna, Koehler, Julia, Kulkarni, Swarupa, Lightfoot, Megan, Nicholls, Ian, Page, Christopher, Pergl-Wilson, Giles, Popa, Mariana Oana, Robinson, Richard, Rowlands, David, Sharp, Tom, Spendiff, Matthew, Stanley, Emily, Steward, Oliver, Taylor, Roger J, Tranter, Pamela, Wagner, Trixie, Watson, Hazel, Williams, Gareth, Wright, Penny, Young, Alice, Sandham, David A

“…Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) ion channel are established as the primary causative factor in the devastating lung…”
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Absorption, Distribution, Metabolism, and Excretion of the Oral Prostaglandin D2 Receptor 2 Antagonist Fevipiprant (QAW039) in Healthy Volunteers and In Vitro by Pearson, David, Weiss, H Markus, Jin, Yi, Jaap van Lier, Jan, Erpenbeck, Veit J, Glaenzel, Ulrike, End, Peter, Woessner, Ralph, Eggimann, Fabian, Camenisch, Gian

“…Fevipiprant is a novel oral prostaglandin D receptor 2 (DP ; also known as CRTh2) antagonist, which is currently in development for the treatment of severe…”
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Absorption, distribution, metabolism, and excretion of [14C]BYL719 (alpelisib) in healthy male volunteers by James, Alexander, Blumenstein, Lars, Glaenzel, Ulrike, Jin, Yi, Demailly, Arnold, Jakab, Annamaria, Hansen, Regine, Hazell, Katharine, Mehta, Anuradha, Trandafir, Lucia, Swart, Piet

“…Purpose To determine the pharmacokinetics of the p110α-selective inhibitor alpelisib (BYL719) in humans, to identify metabolites in plasma and excreta, and to…”
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Pharmacokinetics, Metabolism, and Disposition of Deferasirox in β-Thalassemic Patients with Transfusion-Dependent Iron Overload Who Are at Pharmacokinetic Steady State by WALDMEIER, Felix, BRUIN, Gerard J, GLAENZEL, Ulrike, HAZELL, Katharine, SECHAUD, Romain, WARRINGTON, Steve, PORTER, John B

“…Deferasirox (ICL670) is a novel once-daily, orally administered iron chelator to treat chronic iron overload in patients with transfusion-dependent anemias…”
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Metabolism and Disposition of Siponimod, a Novel Selective S1P 1 /S1P 5 Agonist, in Healthy Volunteers and In Vitro Identification of Human Cytochrome P450 Enzymes Involved in Its Oxidative Metabolism by Glaenzel, Ulrike, Jin, Yi, Nufer, Robert, Li, Wenkui, Schroer, Kirsten, Adam-Stitah, Sylvie, Peter van Marle, Sjoerd, Legangneux, Eric, Borell, Hubert, James, Alexander D, Meissner, Axel, Camenisch, Gian, Gardin, Anne

“…Siponimod, a next-generation selective sphingosine-1-phosphate receptor modulator, is currently being investigated for the treatment of secondary progressive…”
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Metabolism and disposition of the oral absorption enhancer 14C-radiolabeled 8-(N-2-hydroxy-5-chlorobenzoyl)-amino-caprylic acid (5-CNAC) in healthy postmenopausal women and supplementary investigations in vitro by Gschwind, Hans-Peter, Glaenzel, Ulrike, Waldmeier, Felix, Wirz, Bernard, Sabia, Helene D., Picard, Franck, Markus Weiss, H., Choi, Leslie, Swart, Pieter Jacob, Vasudevan, Ajithkumar, Azria, Moïse

“…8-(N-2-hydroxy-5-chlorobenzoyl)-amino-caprylic acid (5-CNAC), a compound lacking pharmacological activity enhances the absorption of salmon calcitonin, when…”
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