Search Results - "Gladyshev, Vadim N"

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    Selenoproteins: molecular pathways and physiological roles by Labunskyy, Vyacheslav M, Hatfield, Dolph L, Gladyshev, Vadim N

    Published in Physiological reviews (01-07-2014)
    “…Selenium is an essential micronutrient with important functions in human health and relevance to several pathophysiological conditions. The biological effects…”
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    Mechanisms of cancer resistance in long-lived mammals by Seluanov, Andrei, Gladyshev, Vadim N., Vijg, Jan, Gorbunova, Vera

    Published in Nature reviews. Cancer (01-07-2018)
    “…Cancer researchers have traditionally used the mouse and the rat as staple model organisms. These animals are very short-lived, reproduce rapidly and are…”
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    Translation inhibitors cause abnormalities in ribosome profiling experiments by Gerashchenko, Maxim V, Gladyshev, Vadim N

    Published in Nucleic acids research (29-09-2014)
    “…Ribosome profiling and high-throughput sequencing provide unprecedented opportunities for the analysis of mRNA translation. Using this novel method, several…”
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  4. 4

    Analysis and Functional Prediction of Reactive Cysteine Residues by Marino, Stefano M., Gladyshev, Vadim N.

    Published in The Journal of biological chemistry (10-02-2012)
    “…Cys is much different from other common amino acids in proteins. Being one of the least abundant residues, Cys is often observed in functional sites in…”
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    The origin of aging: imperfectness-driven non-random damage defines the aging process and control of lifespan by Gladyshev, Vadim N

    Published in Trends in genetics (01-09-2013)
    “…Physicochemical properties preclude ideal biomolecules and perfect biological functions. This inherent imperfectness leads to the generation of damage by every…”
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    Cysteine Function Governs Its Conservation and Degeneration and Restricts Its Utilization on Protein Surfaces by Marino, Stefano M., Gladyshev, Vadim N.

    Published in Journal of molecular biology (17-12-2010)
    “…Cysteine (Cys) is an enigmatic amino acid residue. Although one of the least abundant, it often occurs in the functional sites of proteins. Whereas free Cys is…”
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  7. 7

    Methionine restriction and life-span control by Lee, Byung Cheon, Kaya, Alaattin, Gladyshev , Vadim N.

    Published in Annals of the New York Academy of Sciences (01-01-2016)
    “…Dietary restriction (DR) without malnutrition is associated with longevity in various organisms. However, it has also been shown that reduced calorie intake is…”
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  8. 8

    Biohorology and biomarkers of aging: Current state-of-the-art, challenges and opportunities by Galkin, Fedor, Mamoshina, Polina, Aliper, Alex, de Magalhães, João Pedro, Gladyshev, Vadim N., Zhavoronkov, Alex

    Published in Ageing research reviews (01-07-2020)
    “…[Display omitted] Telomere length, gene expression, blood chemical parameters and DNA-methylation status all undergo age-associated changes, which can be…”
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  9. 9

    Comparative genetics of longevity and cancer: insights from long-lived rodents by Gorbunova, Vera, Seluanov, Andrei, Zhang, Zhengdong, Gladyshev, Vadim N., Vijg, Jan

    Published in Nature reviews. Genetics (01-08-2014)
    “…Key Points Comparative biology provides a powerful tool for understanding mechanisms of longevity and cancer resistance. The rodent clade is particularly…”
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  10. 10

    Genome-wide ribosome profiling reveals complex translational regulation in response to oxidative stress by Gerashchenko, Maxim V, Lobanov, Alexei V, Gladyshev, Vadim N

    “…Information on unique and coordinated regulation of transcription and translation in response to stress is central to the understanding of cellular…”
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    Using DNA Methylation Profiling to Evaluate Biological Age and Longevity Interventions by Petkovich, Daniel A, Podolskiy, Dmitriy I, Lobanov, Alexei V, Lee, Sang-Goo, Miller, Richard A, Gladyshev, Vadim N

    Published in Cell metabolism (04-04-2017)
    “…The DNA methylation levels of certain CpG sites are thought to reflect the pace of human aging. Here, we developed a robust predictor of mouse biological age…”
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    The long and winding road of reprogramming-induced rejuvenation by Yücel, Ali Doğa, Gladyshev, Vadim N.

    Published in Nature communications (02-03-2024)
    “…Organismal aging is inherently connected to the aging of its constituent cells and systems. Reducing the biological age of the organism may be assisted by…”
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  15. 15

    Endogenous Hydrogen Sulfide Production Is Essential for Dietary Restriction Benefits by Hine, Christopher, Harputlugil, Eylul, Zhang, Yue, Ruckenstuhl, Christoph, Lee, Byung Cheon, Brace, Lear, Longchamp, Alban, Treviño-Villarreal, Jose H., Mejia, Pedro, Ozaki, C. Keith, Wang, Rui, Gladyshev, Vadim N., Madeo, Frank, Mair, William B., Mitchell, James R.

    Published in Cell (15-01-2015)
    “…Dietary restriction (DR) without malnutrition encompasses numerous regimens with overlapping benefits including longevity and stress resistance, but unifying…”
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    Global remodeling of the mouse DNA methylome during aging and in response to calorie restriction by Sziráki, András, Tyshkovskiy, Alexander, Gladyshev, Vadim N.

    Published in Aging cell (01-06-2018)
    “…Summary Aging is characterized by numerous molecular changes, such as accumulation of molecular damage and altered gene expression, many of which are linked to…”
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    Pathogenic Variants in Selenoproteins and Selenocysteine Biosynthesis Machinery by Santesmasses, Didac, Gladyshev, Vadim N

    “…Selenium is incorporated into selenoproteins as the 21st amino acid selenocysteine (Sec). There are 25 selenoproteins encoded in the human genome, and their…”
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    The biological significance of methionine sulfoxide stereochemistry by Lee, Byung Cheon, Gladyshev, Vadim N.

    Published in Free radical biology & medicine (15-01-2011)
    “…Methionine can be oxidized by reactive oxygen species to a mixture of two diastereomers, methionine- S-sulfoxide and methionine- R-sulfoxide. Both free amino…”
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    Regulation of protein function by reversible methionine oxidation and the role of selenoprotein MsrB1 by Kaya, Alaattin, Lee, Byung Cheon, Gladyshev, Vadim N

    Published in Antioxidants & redox signaling (01-10-2015)
    “…Protein structure and function can be regulated via post-translational modifications by numerous enzymatic and nonenzymatic mechanisms. Regulation involving…”
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