Search Results - "Gladyshev, Vadim N"
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Selenoproteins: molecular pathways and physiological roles
Published in Physiological reviews (01-07-2014)“…Selenium is an essential micronutrient with important functions in human health and relevance to several pathophysiological conditions. The biological effects…”
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Mechanisms of cancer resistance in long-lived mammals
Published in Nature reviews. Cancer (01-07-2018)“…Cancer researchers have traditionally used the mouse and the rat as staple model organisms. These animals are very short-lived, reproduce rapidly and are…”
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3
Translation inhibitors cause abnormalities in ribosome profiling experiments
Published in Nucleic acids research (29-09-2014)“…Ribosome profiling and high-throughput sequencing provide unprecedented opportunities for the analysis of mRNA translation. Using this novel method, several…”
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Analysis and Functional Prediction of Reactive Cysteine Residues
Published in The Journal of biological chemistry (10-02-2012)“…Cys is much different from other common amino acids in proteins. Being one of the least abundant residues, Cys is often observed in functional sites in…”
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The origin of aging: imperfectness-driven non-random damage defines the aging process and control of lifespan
Published in Trends in genetics (01-09-2013)“…Physicochemical properties preclude ideal biomolecules and perfect biological functions. This inherent imperfectness leads to the generation of damage by every…”
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Cysteine Function Governs Its Conservation and Degeneration and Restricts Its Utilization on Protein Surfaces
Published in Journal of molecular biology (17-12-2010)“…Cysteine (Cys) is an enigmatic amino acid residue. Although one of the least abundant, it often occurs in the functional sites of proteins. Whereas free Cys is…”
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Methionine restriction and life-span control
Published in Annals of the New York Academy of Sciences (01-01-2016)“…Dietary restriction (DR) without malnutrition is associated with longevity in various organisms. However, it has also been shown that reduced calorie intake is…”
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Biohorology and biomarkers of aging: Current state-of-the-art, challenges and opportunities
Published in Ageing research reviews (01-07-2020)“…[Display omitted] Telomere length, gene expression, blood chemical parameters and DNA-methylation status all undergo age-associated changes, which can be…”
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Comparative genetics of longevity and cancer: insights from long-lived rodents
Published in Nature reviews. Genetics (01-08-2014)“…Key Points Comparative biology provides a powerful tool for understanding mechanisms of longevity and cancer resistance. The rodent clade is particularly…”
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Genome-wide ribosome profiling reveals complex translational regulation in response to oxidative stress
Published in Proceedings of the National Academy of Sciences - PNAS (23-10-2012)“…Information on unique and coordinated regulation of transcription and translation in response to stress is central to the understanding of cellular…”
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Using DNA Methylation Profiling to Evaluate Biological Age and Longevity Interventions
Published in Cell metabolism (04-04-2017)“…The DNA methylation levels of certain CpG sites are thought to reflect the pace of human aging. Here, we developed a robust predictor of mouse biological age…”
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DNA methylation aging clocks: challenges and recommendations
Published in Genome Biology (25-11-2019)“…Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure subject age. These clocks are acknowledged as a highly accurate molecular…”
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Accelerated transcriptional elongation during aging impairs longevity
Published in Cell research (01-11-2023)Get full text
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14
The long and winding road of reprogramming-induced rejuvenation
Published in Nature communications (02-03-2024)“…Organismal aging is inherently connected to the aging of its constituent cells and systems. Reducing the biological age of the organism may be assisted by…”
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Endogenous Hydrogen Sulfide Production Is Essential for Dietary Restriction Benefits
Published in Cell (15-01-2015)“…Dietary restriction (DR) without malnutrition encompasses numerous regimens with overlapping benefits including longevity and stress resistance, but unifying…”
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LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation
Published in Cell metabolism (02-04-2019)“…Mice deficient for SIRT6 exhibit a severely shortened lifespan, growth retardation, and highly elevated LINE1 (L1) activity. Here we report that…”
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Global remodeling of the mouse DNA methylome during aging and in response to calorie restriction
Published in Aging cell (01-06-2018)“…Summary Aging is characterized by numerous molecular changes, such as accumulation of molecular damage and altered gene expression, many of which are linked to…”
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Pathogenic Variants in Selenoproteins and Selenocysteine Biosynthesis Machinery
Published in International journal of molecular sciences (27-10-2021)“…Selenium is incorporated into selenoproteins as the 21st amino acid selenocysteine (Sec). There are 25 selenoproteins encoded in the human genome, and their…”
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The biological significance of methionine sulfoxide stereochemistry
Published in Free radical biology & medicine (15-01-2011)“…Methionine can be oxidized by reactive oxygen species to a mixture of two diastereomers, methionine- S-sulfoxide and methionine- R-sulfoxide. Both free amino…”
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Regulation of protein function by reversible methionine oxidation and the role of selenoprotein MsrB1
Published in Antioxidants & redox signaling (01-10-2015)“…Protein structure and function can be regulated via post-translational modifications by numerous enzymatic and nonenzymatic mechanisms. Regulation involving…”
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