Search Results - "Gladstone, Patricia L"

Synthesis and Evaluation of Multisubstrate Bicyclic Pyrimidine Nucleoside Inhibitors of Human Thymidine Phosphorylase by Allan, Amy L, Gladstone, Patricia L, Price, Melissa L. P, Hopkins, Stephanie A, Juarez, Jose C, Doñate, Fernando, Ternansky, Robert J, Shaw, David E, Ganem, Bruce, Li, Yingbo, Wang, Weiru, Ealick, Steven

“…A series of novel, multisubstrate, bicyclic pyrimidine nucleoside inhibitors of human thymidine phosphorylase (TP) is described. Thymidine phosphorylase has…”
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CuCl-Mediated Intramolecular Oxidative Coupling of Aryl- and Alkenyltrimethylstannane Functions by Piers, Edward, Yee, James G. K, Gladstone, Patricia L

“…The syntheses of bis-trimethylstannanes 8, 10, 12−14, 16, 18, 21, and 22 are described. Treatment of these substances with ∼5 equiv of CuCl in DMF at rt for…”
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Design of novel N-(2,4-dioxo-1,2,3,4-tetrahydro-thieno[3,2- d]pyrimidin-7-yl)-guanidines as thymidine phosphorylase inhibitors, and flexible docking to a homology model by Price, MelissaL.P., Guida, WayneC, Jackson, TaraE, Nydick, JasonA, Gladstone, PatriciaL, Juarez, JoséC., Doñate, Fernando, Ternansky, RobertJ

“…A novel class of thymidine phosphorylase (TP) inhibitors has been designed based on analogy to the enzyme substrate as well as known inhibitors. Flexible…”
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Synthesis of Tricyclic β-Methylene Spiro Lactones Related to Bakkenolides by Successive Radical Cyclization−High Pressure Diels−Alder Reactions by Back, Thomas G, Gladstone, Patricia L, Parvez, Masood

“…The synthesis of some novel bakkenolides and their epi-spiro analogues was achieved by a new approach. Photolysis of allyl…”
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A novel stereospecific rearrangement of 3-substituted B-homo-5-azasteroids to their A-nor analogs. Preparation, stereochemistry, and conformational studies by Back, Thomas G, Chau, Joseph H. L, Codding, Penelope W, Gladstone, Patricia L, Jones, David H, Morzycki, Jacek W, Roszak, Aleksander W

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Intermolecular homocoupling of alkenyltrimethylstannane functions mediated by CuCl: Preparation of functionalized conjugated diene and tetraene systems by Piers, Edward, Gladstone, Patricia L., Yee, James G.K., McEachern, Ernest J.

“…Copper(I) chloride-mediated oxidative homocouplings of a variety of substrates containing an alkenyltrimethylstannane function are reported. Thus, treatment of…”
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