Search Results - "Gladilina, Yulia A."

Engineering and Expression Strategies for Optimization of L-Asparaginase Development and Production by Shishparenok, Anastasiya N, Gladilina, Yulia A, Zhdanov, Dmitry D

“…Genetic engineering for heterologous expression has advanced in recent years. Model systems such as , and are often used as host microorganisms for the…”
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Cytoprotective Activity of Polyamines Is Associated with the Alternative Splicing of RAD51A Pre-mRNA in Normal Human CD4 + T Lymphocytes by Gladilina, Yulia A, Bey, Lylia, Hilal, Abdullah, Neborak, Ekaterina V, Blinova, Varvara G, Zhdanov, Dmitry D

“…Physiological polyamines are ubiquitous polycations with pleiotropic biochemical activities, including regulation of gene expression and cell proliferation as…”
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New Genetic Bomb Trigger: Design, Synthesis, Molecular Dynamics Simulation, and Biological Evaluation of Novel BIBR1532-Related Analogs Targeting Telomerase against Non-Small Cell Lung Cancer by Tawfik, Haytham O, El-Hamaky, Anwar A, El-Bastawissy, Eman A, Shcherbakov, Kirill A, Veselovsky, Alexander V, Gladilina, Yulia A, Zhdanov, Dmitry D, El-Hamamsy, Mervat H

“…Telomeres serve a critical function in cell replication and proliferation at every stage of the cell cycle. Telomerase is a ribonucleoprotein, responsible for…”
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Modulation of Suppressive Activity and Proliferation of Human Regulatory T Cells by Splice-Switching Oligonucleotides Targeting FoxP3 Pre-mRNA by Blinova, Varvara G, Gladilina, Yulia A, Abramova, Anna A, Eliseeva, Daria D, Vtorushina, Valentina V, Shishparenok, Anastasia N, Zhdanov, Dmitry D

“…The maturation, development, and function of regulatory T cells (Tregs) are under the control of the crucial transcription factor Forkhead Box Protein 3…”
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Association of Telomere Length in T Lymphocytes, B Lymphocytes, NK Cells and Monocytes with Different Forms of Age-Related Macular Degeneration by Khalatyan, Anait S, Shishparenok, Anastasiya N, Avetisov, Konstantin S, Gladilina, Yulia A, Blinova, Varvara G, Zhdanov, Dmitry D

“…Age plays a primary role in the development of age-related macular degeneration (AMD). Telomere length (TL) is one of the most relevant biomarkers of aging. In…”
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Induction of FoxP3 Pre-mRNA Alternative Splicing to Enhance the Suppressive Activity of Regulatory T Cells from Amyotrophic Lateral Sclerosis Patients by Zhdanov, Dmitry D, Gladilina, Yulia A, Blinova, Varvara G, Abramova, Anna A, Shishparenok, Anastasia N, Eliseeva, Daria D

“…Forkhead box protein 3 (FoxP3) is a key transcription factor responsible for the development, maturation, and function of regulatory T cells (Tregs). The FoxP3…”
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Electrochemical approach for the analysis of DNA degradation in native DNA and apoptotic cells by Agafonova, Lyubov E., Zhdanov, Dmitry D., Gladilina, Yulia A., Shishparenok, Anastasia N., Shumyantseva, Victoria V.

“…The aim of this work was to develop an electrochemical approach for the analysis of DNA degradation and fragmentation in apoptotic cells. DNA damage is…”
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Phenotypical and Functional Characteristics of Human Regulatory T Cells during Ex Vivo Maturation from CD4+ T Lymphocytes by Blinova, Varvara G., Novachly, Natalia S., Gippius, Sofya N., Hilal, Abdullah, Gladilina, Yulia A., Eliseeva, Daria D., Zhdanov, Dmitry D.

“…Regulatory T cells (Tregs) participate in the negative regulation of inflammatory reactions by suppressing effector cells. In a number of autoimmune disorders,…”
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Bacterial cellulose films for L-asparaginase delivery to melanoma cells by Shishparenok, Anastasiya N., Koroleva, Svetlana A., Dobryakova, Natalya V., Gladilina, Yulia A., Gromovykh, Tatiana I., Solopov, Alexey B., Kudryashova, Elena V., Zhdanov, Dmitry D.

“…L-asparaginase (L-ASNase) is an enzyme that catalyzes the hydrolysis of L-asparagine to L-aspartic acid and ammonia and is used to treat acute lymphoblastic…”
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Mechanisms of the Antiproliferative and Antitumor Activity of Novel Telomerase–Carbonic Anhydrase Dual-Hybrid Inhibitors by Plyasova, Anna A, Berrino, Emanuela, Khan, Irina I, Veselovsky, Alexander V, Pokrovsky, Vadim S, Angeli, Andrea, Ferraroni, Marta, Supuran, Claudiu T, Pokrovskaya, Marina V, Alexandrova, Svetlana S, Gladilina, Yulia A, Sokolov, Nikolay N, Hilal, Abdullah, Carta, Fabrizio, Zhdanov, Dmitry D

“…Human (h) telomerase (TL; EC 2.7.7.49) plays a key role in sustaining cancer cells by means of elongating telomeric repeats at the 3′ ends of chromosomes…”
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Inhibition of telomerase activity by splice-switching oligonucleotides targeting the mRNA of the telomerase catalytic subunit affects proliferation of human CD4+ T lymphocytes by Zhdanov, Dmitry D., Plyasova, Anna A., Gladilina, Yulia A., Pokrovsky, Vadim S., Grishin, Dmitry V., Grachev, Vladimir A., Orlova, Valentina S., Pokrovskaya, Marina V., Alexandrova, Svetlana S., Lobaeva, Tatiana A., Sokolov, Nikolay N.

“…Telomerase activity is regulated at the mRNA level by alternative splicing (AS) of its catalytic subunit hTERT. The aim of this study was to define the ability…”
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Contact-independent suppressive activity of regulatory T cells is associated with telomerase inhibition, telomere shortening and target lymphocyte apoptosis by Zhdanov, Dmitry D., Gladilina, Yulia A., Grishin, Dmitry V., Grachev, Vladimir A., Orlova, Valentina S., Pokrovskaya, Marina V., Alexandrova, Svetlana S., Pokrovsky, Vadim S., Sokolov, Nikolai N.

“…•Human Tregs induce target lymphocytes death upon contact-independent co-cultivation.•Tregs induces alternative splicing of telomerase mRNA in target…”
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Inhibition of nuclease activity by a splice-switching oligonucleotide targeting deoxyribonuclease 1 mRNA prevents apoptosis progression and prolong viability of normal human CD4+ T-lymphocytes by Zhdanov, Dmitry D., Plyasova, Anna A., Pokrovsky, Vadim S., Pokrovskaya, Marina V., Alexandrova, Svetlana S., Gladilina, Yulia A., Sokolov, Nikolay N.

“…The nuclease activity of deoxyribonuclease 1 (DNase I) is regulated by alternative splicing (AS) of its mRNA. The aim of this study was to define the ability…”
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Murine regulatory T cells induce death of effector T, B, and NK lymphocytes through a contact-independent mechanism involving telomerase suppression and telomere-associated senescence by Zhdanov, Dmitry D., Gladilina, Yulia A., Pokrovsky, Vadim S., Grishin, Dmitry V., Grachev, Vladimir A., Orlova, Valentina S., Pokrovskaya, Marina V., Alexandrova, Svetlana S., Sokolov, Nikolay N.

“…•Tregs induce death of effector lymphocytes through a contact-independent mechanism.•The death of effector cells is promoted by telomere-dependent…”
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Endonuclease G modulates the alternative splicing of deoxyribonuclease 1 mRNA in human CD4+ T lymphocytes and prevents the progression of apoptosis by Zhdanov, Dmitry D., Gladilina, Yulia A., Pokrovsky, Vadim S., Grishin, Dmitry V., Grachev, Vladimir A., Orlova, Valentina S., Pokrovskaya, Marina V., Alexandrova, Svetlana S., Plyasova, Anna A., Sokolov, Nikolay N.

“…Apoptotic endonucleases act cooperatively to fragment DNA and ensure the irreversibility of apoptosis. However, very little is known regarding the potential…”
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Rhodospirillum rubruml-asparaginase targets tumor growth by a dual mechanism involving telomerase inhibition by Zhdanov, Dmitry D., Pokrovsky, Vadim S., Pokrovskaya, Marina V., Alexandrova, Svetlana S., Eldarov, Mikhail A., Grishin, Dmitry V., Basharov, Marsel M., Gladilina, Yulia A., Podobed, Olga V., Sokolov, Nikolai N.

“…Rhodospirillum rubruml-asparaginase mutant RrA E149R, V150P, F151T (RrA) was previously identified to down-regulate telomerase activity along with catalyzing…”
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Inhibition of telomerase activity and induction of apoptosis by Rhodospirillum rubrum L‐asparaginase in cancer Jurkat cell line and normal human CD4+ T lymphocytes by Zhdanov, Dmitry D., Pokrovsky, Vadim S., Pokrovskaya, Marina V., Alexandrova, Svetlana S., Eldarov, Mikhail A., Grishin, Dmitry V., Basharov, Marsel M., Gladilina, Yulia A., Podobed, Olga V., Sokolov, Nikolai N.

“…Rhodospirillum rubrum L‐asparaginase mutant E149R, V150P, F151T (RrA) down‐regulates telomerase activity due to its ability to inhibit the expression of…”
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Rhodospirillum rubrum l-asparaginase targets tumor growth by a dual mechanism involving telomerase inhibition by Zhdanov, Dmitry D., Pokrovsky, Vadim S., Pokrovskaya, Marina V., Alexandrova, Svetlana S., Eldarov, Mikhail A., Grishin, Dmitry V., Basharov, Marsel M., Gladilina, Yulia A., Podobed, Olga V., Sokolov, Nikolai N.

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