Search Results - "Gladden, AB"

An alternatively spliced cyclin D1 isoform, cyclin D1b, is a nuclear oncogene by FENGMIN LU, GLADDEN, Andrew B, DIEHL, J. Alan

“…Glycogen synthase kinase-3beta-dependent phosphorylation of cyclin D1 at a conserved COOH-terminal residue, Thr-286, promotes CRM1-dependent cyclin D1 nuclear…”
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Location, location, location: The role of cyclin D1 nuclear localization in cancer by Gladden, Andrew B., Diehl, J. Alan

“…The control of cell proliferation is crucial in maintaining cellular homeostasis and loss of this mechanism is a principle hallmark of cancer cells. A primary…”
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p21(Cip1) Promotes cyclin D1 nuclear accumulation via direct inhibition of nuclear export by Alt, Jodi R, Gladden, Andrew B, Diehl, J Alan

“…There is increasing evidence that p21(Cip1) and p27(Kip1) are requisite positive regulators of cyclin D1.CDK4 assembly and nuclear accumulation. Both Cip and…”
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The Cyclin D1-dependent Kinase Associates with the Pre-replication Complex and Modulates RB·MCM7 Binding by Gladden, Andrew B., Diehl, J. Alan

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Expression of constitutively nuclear cyclin D1 in murine lymphocytes induces B-cell lymphoma by GLADDEN, A. B, WOOLERY, R, AGGARWAL, P, WASIK, M. A, DIEHL, J. A

“…Mantle cell lymphoma (MCL) is a B-cell lymphoma characterized by overexpression of cyclin D1 due to the t(11;14) chromosomal translocation. While expression of…”
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Cell cycle progression without cyclin E/CDK2: Breaking down the walls of dogma by Gladden, Andrew B, Diehl, J.Alan

“…G1 is the phase of the cell cycle wherein the cell is responsive to growth factor-dependent signals. As such, G1 regulation is frequently disrupted in cancer…”
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The Cyclin D1-dependent Kinase Associates with the Pre-replication Complex and Modulates RB super(.)MCM7 Binding by Gladden, AB, Diehl, JA

“…The capacity of the cyclin D-dependent kinase to promote G sub(1) progression through modulation of RB super(.)E2F is well documented. We now demonstrate that…”
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