Search Results - "Gjoerup, Ole"

Genomic Analysis of Circulating Tumor DNA in 3,334 Patients with Advanced Prostate Cancer Identifies Targetable BRCA Alterations and AR Resistance Mechanisms by Tukachinsky, Hanna, Madison, Russell W, Chung, Jon H, Gjoerup, Ole V, Severson, Eric A, Dennis, Lucas, Fendler, Bernard J, Morley, Samantha, Zhong, Lei, Graf, Ryon P, Ross, Jeffrey S, Alexander, Brian M, Abida, Wassim, Chowdhury, Simon, Ryan, Charles J, Fizazi, Karim, Golsorkhi, Tony, Watkins, Simon P, Simmons, Andrew, Loehr, Andrea, Venstrom, Jeffrey M, Oxnard, Geoffrey R

“…Comprehensive genomic profiling (CGP) is of increasing value for patients with metastatic castration-resistant prostate cancer (mCRPC). mCRPC tends to…”
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Clinical and analytical validation of FoundationOne®CDx, a comprehensive genomic profiling assay for solid tumors by Milbury, Coren A, Creeden, James, Yip, Wai-Ki, Smith, David L, Pattani, Varun, Maxwell, Kristi, Sawchyn, Bethany, Gjoerup, Ole, Meng, Wei, Skoletsky, Joel, Concepcion, Alvin D, Tang, Yanhua, Bai, Xiaobo, Dewal, Ninad, Ma, Pei, Bailey, Shannon T, Thornton, James, Pavlick, Dean C, Frampton, Garrett M, Lieber, Daniel, White, Jared, Burns, Christine, Vietz, Christine

“…FoundationOne®CDx (F1CDx) is a United States (US) Food and Drug Administration (FDA)-approved companion diagnostic test to identify patients who may benefit…”
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Predictive Genomic Biomarkers of Hormonal Therapy Versus Chemotherapy Benefit in Metastatic Castration-resistant Prostate Cancer by Graf, Ryon P., Fisher, Virginia, Mateo, Joaquin, Gjoerup, Ole V., Madison, Russell W., Raskina, Kira, Tukachinsky, Hanna, Creeden, James, Cunningham, Rachel, Huang, Richard S.P., Mata, Douglas A., Ross, Jeffrey S., Oxnard, Geoffrey R., Venstrom, Jeffrey M., Zurita, Amado J.

“…Biomarkers available through routine comprehensive genomic profiling, especially AR amplification, can provide value for clinical decision-making by…”
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T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus by Shuda, Masahiro, Feng, Huichen, Kwun, Hyun Jin, Rosen, Steven T, Gjoerup, Ole, Moore, Patrick S, Chang, Yuan

“…Merkel cell polyomavirus (MCV) is a virus discovered in our laboratory at the University of Pittsburgh that is monoclonally integrated into the genome of…”
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Functional connection between Rad51 and PML in homology-directed repair by Boichuk, Sergei, Hu, Liang, Makielski, Kathleen, Pandolfi, Pier Paolo, Gjoerup, Ole V

“…The promyelocytic leukemia protein (PML) is a tumor suppressor critical for formation of nuclear bodies (NBs) performing important functions in transcription,…”
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STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells by Kim, Jong Wook, Berrios, Christian, Kim, Miju, Schade, Amy E, Adelmant, Guillaume, Yeerna, Huwate, Damato, Emily, Iniguez, Amanda Balboni, Florens, Laurence, Washburn, Michael P, Stegmaier, Kim, Gray, Nathanael S, Tamayo, Pablo, Gjoerup, Ole, Marto, Jarrod A, DeCaprio, James, Hahn, William C

“…Alterations involving serine-threonine phosphatase PP2A subunits occur in a range of human cancers, and partial loss of PP2A function contributes to cell…”
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The Pan-Tumor Landscape of Targetable Kinase Fusions in Circulating Tumor DNA by Lee, Jessica K, Hazar-Rethinam, Mehlika, Decker, Brennan, Gjoerup, Ole, Madison, Russell W, Lieber, Daniel S, Chung, Jon H, Schrock, Alexa B, Creeden, James, Venstrom, Jeffrey, Alexander, Brian, Oxnard, Geoffrey R

“…Oncogenic kinase fusions are targetable with approved and investigational therapies and can also mediate acquired resistance (AR) to targeted therapy. We aimed…”
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Multiple DNA Damage Signaling and Repair Pathways Deregulated by Simian Virus 40 Large T Antigen by Boichuk, Sergei, Hu, Liang, Hein, Jennifer, Gjoerup, Ole V

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Tissue and liquid biopsy profiling reveal convergent tumor evolution and therapy evasion in breast cancer by Sivakumar, Smruthy, Jin, Dexter X., Tukachinsky, Hanna, Murugesan, Karthikeyan, McGregor, Kimberly, Danziger, Natalie, Pavlick, Dean, Gjoerup, Ole, Ross, Jeffrey S., Harmon, Robert, Chung, Jon, Decker, Brennan, Dennis, Lucas, Frampton, Garrett M., Molinero, Luciana, Oesterreich, Steffi, Venstrom, Jeffrey M., Oxnard, Geoffrey R., Hegde, Priti S., Sokol, Ethan S.

“…Pathological and genomic profiling have transformed breast cancer care by matching patients to targeted treatments. However, tumors evolve and evade…”
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Comparative Genomic Analysis of Intrahepatic Cholangiocarcinoma: Biopsy Type, Ancestry, and Testing Patterns by Israel, Mason A., Danziger, Natalie, McGregor, Kimberly A., Murugesan, Karthikeyan, Gjoerup, Ole, Sokol, Ethan S., Tukachinsky, Hanna, Kurzrock, Razelle, Kato, Shumei, Sicklick, Jason K., Nimeiri, Halla S., Oxnard, Geoffrey R., Ross, Jeffrey S.

“…Background At diagnosis, the majority of patients with intrahepatic cholangiocarcinoma (IHCC) present with advanced disease and a poor prognosis. Comprehensive…”
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An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer by Li, Ji, Choi, Peter S, Chaffer, Christine L, Labella, Katherine, Hwang, Justin H, Giacomelli, Andrew O, Kim, Jong Wook, Ilic, Nina, Doench, John G, Ly, Seav Huong, Dai, Chao, Hagel, Kimberly, Hong, Andrew L, Gjoerup, Ole, Goel, Shom, Ge, Jennifer Y, Root, David E, Zhao, Jean J, Brooks, Angela N, Weinberg, Robert A, Hahn, William C

“…Alternative splicing of mRNA precursors represents a key gene expression regulatory step and permits the generation of distinct protein products with diverse…”
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Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition by Hong, Andrew L, Tseng, Yuen-Yi, Wala, Jeremiah A, Kim, Won-Jun, Kynnap, Bryan D, Doshi, Mihir B, Kugener, Guillaume, Sandoval, Gabriel J, Howard, Thomas P, Li, Ji, Yang, Xiaoping, Tillgren, Michelle, Ghandi, Mahmhoud, Sayeed, Abeer, Deasy, Rebecca, Ward, Abigail, McSteen, Brian, Labella, Katherine M, Keskula, Paula, Tracy, Adam, Connor, Cora, Clinton, Catherine M, Church, Alanna J, Crompton, Brian D, Janeway, Katherine A, Van Hare, Barbara, Sandak, David, Gjoerup, Ole, Bandopadhayay, Pratiti, Clemons, Paul A, Schreiber, Stuart L, Root, David E, Gokhale, Prafulla C, Chi, Susan N, Mullen, Elizabeth A, Roberts, Charles Wm, Kadoch, Cigall, Beroukhim, Rameen, Ligon, Keith L, Boehm, Jesse S, Hahn, William C

“…Renal medullary carcinoma (RMC) is a rare and deadly kidney cancer in patients of African descent with sickle cell trait. We have developed faithful…”
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Comprehensive Genomic Profiling (CGP)-Informed Personalized Molecular Residual Disease (MRD) Detection: An Exploratory Analysis from the PREDATOR Study of Metastatic Colorectal Cancer (mCRC) Patients Undergoing Surgical Resection by Lonardi, Sara, Nimeiri, Halla, Xu, Chang, Zollinger, Daniel R, Madison, Russell W, Fine, Alexander D, Gjoerup, Ole, Rasola, Cosimo, Angerilli, Valentina, Sharma, Shruti, Wu, Hsin-Ta, Palsuledesai, Charuta C, Malhotra, Meenakshi, Aleshin, Alexey, Loupakis, Fotios, Renkonen, Elise, Hegde, Priti, Fassan, Matteo

“…A majority of patients with metastatic colorectal cancer (mCRC) experience recurrence post curative-intent surgery. The addition of adjuvant chemotherapy has…”
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SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis by Cheng, Hailing, Liu, Pixu, Wang, Zhigang C, Zou, Lihua, Santiago, Stephanie, Garbitt, Victoria, Gjoerup, Ole V, Iglehart, J Dirk, Miron, Alexander, Richardson, Andrea L, Hahn, William C, Zhao, Jean J

“…Resistance to anoikis, the subtype of apoptosis triggered by lack of adhesion, contributes to malignant transformation and the development of metastasis…”
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Prevalence of inferred clonal hematopoiesis (CH) detected on comprehensive genomic profiling (CGP) of solid tumor tissue or circulating tumor DNA (ctDNA) by Antonarakis, Emmanuel S., Kuang, Zheng, Tukachinsky, Hanna, Parachoniak, Christine, Kelly, Andrew David, Gjoerup, Ole, Aiyer, Aparna, Severson, Eric Allan, Pavlick, Dean C., Frampton, Garrett M., Venstrom, Jeffrey Michael, Oxnard, Geoffrey R.

“…Abstract only 3009 Background: The increased use of ctDNA CGP has paralleled increased detection and interest in CH, which can confound CGP results from ctDNA…”
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Cellular and viral factors regulating Merkel cell polyomavirus replication by Feng, Huichen, Kwun, Hyun Jin, Liu, Xi, Gjoerup, Ole, Stolz, Donna B, Chang, Yuan, Moore, Patrick S

“…Merkel cell polyomavirus (MCV), a previously unrecognized component of the human viral skin flora, was discovered as a mutated and clonally-integrated virus…”
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Simian Virus 40 Large T Antigen Disrupts Genome Integrity and Activates a DNA Damage Response via Bub1 Binding by Hein, Jennifer, Boichuk, Sergei, Wu, Jiaping, Cheng, Yuan, Freire, Raimundo, Jat, Parmjit S, Roberts, Thomas M, Gjoerup, Ole V

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Molecular residual disease detection in resected, muscle-invasive urothelial cancer with a tissue-based comprehensive genomic profiling–informed personalized monitoring assay by Powles, Thomas, Young, Amanda, Nimeiri, Halla, Madison, Russell W., Fine, Alexander, Zollinger, Daniel R., Huang, Yanmei, Xu, Chang, Gjoerup, Ole V., Aushev, Vasily N., Wu, Hsin-Ta, Aleshin, Alexey, Carter, Corey, Davarpanah, Nicole, Degaonkar, Viraj, Gupta, Pratyush, Mariathasan, Sanjeev, Schleifman, Erica, Assaf, Zoe June, Oxnard, Geoffrey, Hegde, Priti S.

“…Introduction Circulating tumor DNA (ctDNA) detection postoperatively may identify patients with urothelial cancer at a high risk of relapse. Pragmatic tools…”
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Protein phosphatase 2A regulates life and death decisions via Akt in a context-dependent manner by Andrabi, Shaida, Gjoerup, Ole V, Kean, Jennifer A, Roberts, Thomas M, Schaffhausen, Brian

“…Here, we show how targeting protein phosphatase 2A (PP2A), a key regulator of cellular protein phosphorylation, can either induce or prevent apoptosis…”
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SMAD4 represses FOSL1 expression and pancreatic cancer metastatic colonization by Dai, Chao, Rennhack, Jonathan P., Arnoff, Taylor E., Thaker, Maneesha, Younger, Scott T., Doench, John G., Huang, August Yue, Yang, Annan, Aguirre, Andrew J., Wang, Belinda, Mun, Evan, O’Connell, Joyce T., Huang, Ying, Labella, Katherine, Talamas, Jessica A., Li, Ji, Ilic, Nina, Hwang, Justin, Hong, Andrew L., Giacomelli, Andrew O., Gjoerup, Ole, Root, David E., Hahn, William C.

“…Metastasis is a complex and poorly understood process. In pancreatic cancer, loss of the transforming growth factor (TGF)-β/BMP effector SMAD4 is correlated…”
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