Search Results - "Gjertsen, B T"

Synergistic induction of p53 mediated apoptosis by valproic acid and nutlin-3 in acute myeloid leukemia by McCormack, E, Haaland, I, Venås, G, Forthun, R B, Huseby, S, Gausdal, G, Knappskog, S, Micklem, D R, Lorens, J B, Bruserud, Ø, Gjertsen, B T

“…Although TP53 mutations are rare in acute myeloid leukemia (AML), wild type p53 function is habitually annulled through overexpression of MDM2 or through…”
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HOX gene expression predicts response to BCL-2 inhibition in acute myeloid leukemia by Kontro, M, Kumar, A, Majumder, M M, Eldfors, S, Parsons, A, Pemovska, T, Saarela, J, Yadav, B, Malani, D, Fløisand, Y, Höglund, M, Remes, K, Gjertsen, B T, Kallioniemi, O, Wennerberg, K, Heckman, C A, Porkka, K

“…Inhibitors of B-cell lymphoma-2 (BCL-2) such as venetoclax (ABT-199) and navitoclax (ABT-263) are clinically explored in several cancer types, including acute…”
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Impact of malignant stem cell burden on therapy outcome in newly diagnosed chronic myeloid leukemia patients by Mustjoki, S, Richter, J, Barbany, G, Ehrencrona, H, Fioretos, T, Gedde-Dahl, T, Gjertsen, B T, Hovland, R, Hernesniemi, S, Josefsen, D, Koskenvesa, P, Dybedal, I, Markevärn, B, Olofsson, T, Olsson-Strömberg, U, Rapakko, K, Thunberg, S, Stenke, L, Simonsson, B, Porkka, K, Hjorth-Hansen, H

“…Chronic myeloid leukemia (CML) stem cells appear resistant to tyrosine kinase inhibitors (TKIs) in vitro, but their impact and drug sensitivity in vivo has not…”
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Safety and efficacy of the combination of pegylated interferon-α2b and dasatinib in newly diagnosed chronic-phase chronic myeloid leukemia patients by Hjorth-Hansen, H, Stentoft, J, Richter, J, Koskenvesa, P, Höglund, M, Dreimane, A, Porkka, K, Gedde-Dahl, T, Gjertsen, B T, Gruber, F X, Stenke, L, Eriksson, K M, Markevärn, B, Lübking, A, Vestergaard, H, Udby, L, Bjerrum, O W, Persson, I, Mustjoki, S, Olsson-Strömberg, U

“…Dasatinib (DAS) and interferon-α have antileukemic and immunostimulatory effects and induce deep responses in chronic myeloid leukemia (CML). We assigned 40…”
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Review: genetic models of acute myeloid leukaemia by McCormack, E, Bruserud, O, Gjertsen, B T

“…The use of genetically engineered mice (GEM) have been critical in understanding disease states such as cancer, and none more so than acute myelogenous…”
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Discovery and development of the Polo-like kinase inhibitor volasertib in cancer therapy by Gjertsen, B T, Schöffski, P

“…Owing to their integral involvement in cell cycle regulation, the Polo-like kinase (Plk) family, particularly Plk1, has emerged as an attractive therapeutic…”
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Release of angiopoietin-1 by primary human acute myelogenous leukemia cells is associated with mutations of nucleophosmin, increased by bone marrow stromal cells and possibly antagonized by high systemic angiopoietin-2 levels by Hatfield, K J, Hovland, R, Øyan, A M, Kalland, K H, Ryningen, A, Gjertsen, B T, Bruserud, Ø

“…The balance between proangiogenic Angiopoietin-1 (Ang-1) and the antagonistic Ang-2 is important both for leukemogenesis and chemosensitivity in human acute…”
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Khat -induced apoptosis is inhibited by antagonists of caspase-1 and -8 in human leukaemia cells by DIMBA, E. A. O, GJERTSEN, B. T, BREDHOLT, T, FOSSAN, K. O, COSTEA, D. E, FRANCIS, G. W, JOHANNESSEN, A. C, VINTERMYR, O. K

“…Khat chewing is a widespread habit that has a deep-rooted sociocultural tradition in Africa and the Middle East. The biological effects of khat are…”
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Immunogenic effects of recombinant interferon-beta therapy disrupt the JAK/STAT pathway in primary immune cells from patients with multiple sclerosis by Gavasso, S, Gjertsen, BT, Anderssen, E, Myhr, KM, Vedeler, C

“…Background: Immunogenicity of recombinant interferon-β (IFN-β) is a known complication in the therapy of relapsing–remitting multiple sclerosis (RRMS)…”
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Animal models of acute myelogenous leukaemia - development, application and future perspectives by MC CORMACK, E, BRUSERUD, Ø, GJERTSEN, B. T

“…From the early inception of the transplant models through to contemporary genetic and xenograft models, evolution of murine leukaemic model systems have been…”
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Caspase-dependent, geldanamycin-enhanced cleavage of co-chaperone p23 in leukemic apoptosis by GAUSDAL, G, GJERTSEN, B. T, FLADMARK, K. E, DEMOL, H, VANDEKERCKHOVE, J, DØSKELAND, S-O

“…Co-chaperone p23 is a component of the heat-shock protein (Hsp)90 multiprotein-complex and is an important modulator of Hsp90 activity. Hsp90 client proteins…”
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Safety and efficacy of the combination of pegylated interferon- alpha 2b and dasatinib in newly diagnosed chronic-phase chronic myeloid leukemia patients by Hjorth-Hansen, H, Stentoft, J, Richter, J, Koskenvesa, P, Hoglund, M, Dreimane, A, Porkka, K, Gedde-Dahl, T, Gjertsen, B T, Gruber, F X, Stenke, L, Eriksson, K M, Markevaern, B, Luebking, A, Vestergaard, H, Udby, L, Bjerrum, O W, Persson, I, Mustjoki, S, Olsson-Stromberg, U

“…Dasatinib (DAS) and interferon- alpha have antileukemic and immunostimulatory effects and induce deep responses in chronic myeloid leukemia (CML). We assigned…”
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Catha edulis (Khat) Induces Cell Death by Apoptosis in Leukemia Cell Lines by DIMBA, E, GJERTSEN, B T., FRANCIS, G W., JOHANNESSEN, A C., VINTERMYR, O K.

“…: Khat is the Celastraceus edulis plant, a flowering evergreen tree or large shrub, which grows in the Horn of Africa and southwestern Arabia. Khat use has…”
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Update on the randomised phase Ib/II study of the selective small molecule AXL inhibitor bemcentinib (BGB324) in combination with either dabrafenib/trametinib or pembrolizumab in patients with metastatic melanoma by Schuster, C., Gausdal, G., Gjertsen, B.T., Lorens, J., Straume, O.

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Novel activating STAT5B mutations as putative drivers of T-cell acute lymphoblastic leukemia by Kontro, M, Kuusanmäki, H, Eldfors, S, Burmeister, T, Andersson, E I, Bruserud, Ø, Brümmendorf, T H, Edgren, H, Gjertsen, B T, Itälä-Remes, M, Lagström, S, Lohi, O, Lundán, T, Martí, J M L, Majumder, M M, Parsons, A, Pemovska, T, Rajala, H, Vettenranta, K, Kallioniemi, O, Mustjoki, S, Porkka, K, Heckman, C A

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Tunneling nanotube (TNT) formation is independent of p53 expression by Andresen, V, Wang, X, Ghimire, S, Omsland, M, Gjertsen, B T, Gerdes, H H

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Inherited Mutations in PTEN That Are Associated with Breast Cancer, Cowden Disease, and Juvenile Polyposis by Lynch, Eric D., Ostermeyer, Elizabeth A., Lee, Ming K., Arena, J. Fernando, Ji, HanLee, Dann, Jamie, Swisshelm, Karen, Suchard, David, MacLeod, Patrick M., Kvinnsland, Stener, Gjertsen, Bjorn Tore, Heimdal, Ketil, Lubs, Herb, Møller, Pål, King, Mary-Claire

“…PTEN, a protein tyrosine phosphatase with homology to tensin, is a tumor-suppressor gene on chromosome 10q23. Somatic mutations in PTEN occur in multiple…”
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Flow cytometric measurement of apoptosis and necrosis in cryopreserved PBPC concentrates from patients with malignant diseases by ABRAHAMSEN, J. F, BAKKEN, A. M, BRUSERUD, Ø, GJERTSEN, B. T

“…The number of viable precursor cells actually reinfused into patients after high-dose chemotherapy is one of the most clinically important variables…”
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PB1785: DISCOVERY OF APPROVED LOW-TOXICITY AGENTS DISRUPTING ACUTE MYELOID LEUKEMIA STEM AND PROGENITOR CELLS by Meilstrup, J., Leitch, C., Kriegbaum, M., Andresen, V., Gjertsen, B. T., Wennerberg, K.

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Double-blind, right/left comparison of calcipotriol and betamethasone valerate in treatment of psoriasis vulgaris by Kragballe, K, Gjertsen, B T, De Hoop, D, Karlsmark, T, van de Kerkhof, P C, Larkö, O, Nieboer, C, Roed-Petersen, J, Strand, A, Tikjøb, G

“…The therapeutic efficacy and tolerability of calcipotriol ointment and betamethasone valerate ointment in psoriasis were compared in a multicentre,…”
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