Acute effects of high intensity training on cardiac function: a pilot study comparing subjects with type 2 diabetes to healthy controls

Acute effects of high intensity training on cardiac function: a pilot study comparing subjects with type 2 diabetes to healthy controls

This study evaluated acute cardiac stress after a high-intensity interval training session in patients with type 2 diabetes (T2D) versus healthy controls. High intensity aerobic exercise was performed by 4 × 4-min intervals (90–95% of maximal heart rate), followed by a ramp protocol to peak oxygen u...

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Bibliographic Details
Published in:Scientific reports Vol. 12; no. 1; p. 8239
Main Authors: Ness, Henning O., Ljones, Kristine, Gjelsvik, Randi H., Tjønna, Arnt Erik, Malmo, Vegard, Nilsen, Hans Olav, Hollekim-Strand, Siri Marte, Dalen, Håvard, Høydal, Morten Andre
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 17-05-2022
Nature Publishing Group
Nature Portfolio
Subjects:
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631/443/592/75
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692/4019/592
Acute effects
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2
Diastole - physiology
Echocardiography
EKG
Exercise
Exercise Test
Heart rate
Humanities and Social Sciences
Humans
multidisciplinary
NCT
NCT02998008
Oxygen uptake
Physical training
Pilot Projects
Science
Science (multidisciplinary)
Training
Velocity
Ventricle
Ventricular Function, Left - physiology
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Summary:This study evaluated acute cardiac stress after a high-intensity interval training session in patients with type 2 diabetes (T2D) versus healthy controls. High intensity aerobic exercise was performed by 4 × 4-min intervals (90–95% of maximal heart rate), followed by a ramp protocol to peak oxygen uptake. Echocardiography was performed before and 30 min after exercise. Holter electrocardiography monitored heart rhythms 24 h before, during, and 24 h after the exercise. Left atrial end-systolic volume, peak early diastolic mitral annular velocity, and the ratio of peak early to late diastolic mitral inflow velocity were reduced by approximately 18%, 15%, and 31%, respectively, after exercise across groups. Left ventricular end-diastolic wall thickness was the only echo parameter that significantly differed between groups in response to exercise. The T2D group had a rate of supraventricular extrasystoles per hour that was 265% greater than that of the controls before exercise, which remained higher after exercise. A single exhaustive exercise session impaired left ventricular diastolic function in both groups. The findings also indicated impaired right ventricular function in patients with T2D after exercise. ClinicalTrials.gov Identifier: NCT02998008.
Bibliography:ObjectType-Article-2
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-12375-2