Search Results - "Gjaltema, F"

Writing of H3K4Me3 overcomes epigenetic silencing in a sustained but context-dependent manner by Cano-Rodriguez, David, Gjaltema, Rutger A F., Jilderda, Laura J, Jellema, Pytrick, Dokter-Fokkens, Jelleke, Ruiters, Marcel H J., Rots, Marianne G

“…Histone modifications reflect gene activity, but the relationship between cause and consequence of transcriptional control is heavily debated. Recent…”
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CasTuner is a degron and CRISPR/Cas-based toolkit for analog tuning of endogenous gene expression by Noviello, Gemma, Gjaltema, Rutger A. F., Schulz, Edda G.

“…Certain cellular processes are dose-dependent, requiring specific quantities or stoichiometries of gene products, as exemplified by haploinsufficiency and…”
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Disentangling mechanisms involved in collagen pyridinoline cross-linking: The immunophilin FKBP65 is critical for dimerization of lysyl hydroxylase 2 by Gjaltema, Rutger A. F., van der Stoel, Miesje M., Boersema, Miriam, Bank, Ruud A.

“…Collagens are subjected to extensive posttranslational modifications, such as lysine hydroxylation. Bruck syndrome (BS) is a connective tissue disorder…”
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Reciprocal regulation of endothelial–mesenchymal transition by MAPK7 and EZH2 in intimal hyperplasia and coronary artery disease by Vanchin, Byambasuren, Sol, Marloes, Gjaltema, Rutger A. F., Brinker, Marja, Kiers, Bianca, Pereira, Alexandre C., Harmsen, Martin C., Moonen, Jan-Renier A. J., Krenning, Guido

“…Endothelial–mesenchymal transition (EndMT) is a form of endothelial dysfunction wherein endothelial cells acquire a mesenchymal phenotype and lose endothelial…”
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Targeted epigenetic editing of SPDEF reduces mucus production in lung epithelial cells by Song, Juan, Cano-Rodriquez, David, Winkle, Melanie, Gjaltema, Rutger A F, Goubert, Désirée, Jurkowski, Tomasz P, Heijink, Irene H, Rots, Marianne G, Hylkema, Machteld N

“…Airway mucus hypersecretion contributes to the morbidity and mortality in patients with chronic inflammatory lung diseases. Reducing mucus production is…”
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HDAC1-3 inhibitor MS-275 enhances IL10 expression in RAW264.7 macrophages and reduces cigarette smoke-induced airway inflammation in mice by Leus, Niek G. J., van den Bosch, Thea, van der Wouden, Petra E., Krist, Kim, Ourailidou, Maria E., Eleftheriadis, Nikolaos, Kistemaker, Loes E. M., Bos, Sophie, Gjaltema, Rutger A. F., Mekonnen, Solomon A., Bischoff, Rainer, Gosens, Reinoud, Haisma, Hidde J., Dekker, Frank J.

“…Chronic obstructive pulmonary disease (COPD) constitutes a major health burden. Studying underlying molecular mechanisms could lead to new therapeutic targets…”
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KRAB-Induced Heterochromatin Effectively Silences PLOD2 Gene Expression in Somatic Cells and is Resilient to TGFβ1 Activation by Gjaltema, Rutger A F, Goubert, Désirée, Huisman, Christian, Pilar García Tobilla, Consuelo Del, Koncz, Mihály, Jellema, Pytrick G, Wu, Dandan, Brouwer, Uilke, Kiss, Antal, Verschure, Pernette J, Bank, Ruud A, Rots, Marianne G

“…Epigenetic editing, an emerging technique used for the modulation of gene expression in mammalian cells, is a promising strategy to correct disease-related…”
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Advances of epigenetic editing by Gjaltema, Rutger A.F., Rots, Marianne G.

“…Epigenetic editing refers to the locus-specific targeting of epigenetic enzymes to rewrite the local epigenetic landscape of an endogenous genomic site, often…”
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Molecular insights into prolyl and lysyl hydroxylation of fibrillar collagens in health and disease by Gjaltema, Rutger A F, Bank, Ruud A

“…Collagen is a macromolecule that has versatile roles in physiology, ranging from structural support to mediating cell signaling. Formation of mature collagen…”
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Fine-Tuning the Epigenetic Landscape: Chemical Modulation of Epigenome Editors by Noviello, Gemma, Gjaltema, Rutger A F

“…Epigenome editing has emerged as a powerful technique for targeted manipulation of the chromatin and transcriptional landscape, employing designer DNA binding…”
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Procollagen Lysyl Hydroxylase 2 Expression Is Regulated by an Alternative Downstream Transforming Growth Factor β-1 Activation Mechanism by Gjaltema, Rutger A.F., de Rond, Saskia, Rots, Marianne G., Bank, Ruud A.

“…PLOD2 (procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2) hydroxylates lysine residues in collagen telopeptides and is essential for collagen pyridinoline…”
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Distal and proximal cis-regulatory elements sense X chromosome dosage and developmental state at the Xist locus by Gjaltema, Rutger A.F., Schwämmle, Till, Kautz, Pauline, Robson, Michael, Schöpflin, Robert, Ravid Lustig, Liat, Brandenburg, Lennart, Dunkel, Ilona, Vechiatto, Carolina, Ntini, Evgenia, Mutzel, Verena, Schmiedel, Vera, Marsico, Annalisa, Mundlos, Stefan, Schulz, Edda G.

“…Developmental genes such as Xist, which initiates X chromosome inactivation, are controlled by complex cis-regulatory landscapes, which decode multiple signals…”
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CRISPR/dCas9 Switch Systems for Temporal Transcriptional Control by Gjaltema, Rutger A F, Schulz, Edda G

“…In a swift revolution, CRISPR/Cas9 has reshaped the means and ease of interrogating biological questions. Particularly, mutants that result in a…”
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Plasmid Delivery and Single-Cell Plasmid Expression Analysis for CRISPR/dCas9-Based Epigenetic Editing by van den Berg van Saparoea, Anna C H, van Loosen, Quint C, Sarno, Federica, Ntini, Evgenia, Rots, Marianne G, Gjaltema, Rutger A F, Verschure, Pernette J

“…To fully exploit the potentials of reprogramming the epigenome through CRISPR/dCas9 systems for epigenetic editing, there is a growing need for improved…”
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Ascorbic acid promotes a TGFβ1‐induced myofibroblast phenotype switch by Piersma, Bram, Wouters, Olaf Y., Rond, Saskia, Boersema, Miriam, Gjaltema, Rutger A. F., Bank, Ruud A.

“…l‐Ascorbic acid (AA), generally known as vitamin C, is a crucial cofactor for a variety of enzymes, including prolyl‐3‐hydroxylase (P3H), prolyl‐4‐hydroxylase…”
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Ascorbic acid promotes a TGF β 1-induced myofibroblast phenotype switch by Piersma, Bram, Wouters, Olaf Y, de Rond, Saskia, Boersema, Miriam, Gjaltema, Rutger A F, Bank, Ruud A

“…l-Ascorbic acid (AA), generally known as vitamin C, is a crucial cofactor for a variety of enzymes, including prolyl-3-hydroxylase (P3H), prolyl-4-hydroxylase…”
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Enhancer of zeste homolog-2 (EZH2) methyltransferase regulates transgelin/smooth muscle-22α expression in endothelial cells in response to interleukin-1β and transforming growth factor-β2 by Maleszewska, Monika, Gjaltema, Rutger A.F., Krenning, Guido, Harmsen, Martin C.

“…Smooth muscle-22α (SM22α), encoded by transgelin (TAGLN), is expressed in mesenchymal lineage cells, including myofibroblasts and smooth muscle cells. It is an…”
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A Precision Experiment to Investigate Long-Lived Radioactive Decays by Angevaare, J. R, Barrow, P, Baudis, L, Breur, P. A, Brown, A, Colijn, A. P, Cox, G, Gienal, M, Gjaltema, F, Helmling-Cornell, A, Jones, M, Kish, A, Kurz, M, Kubley, T, Lang, R. F, Massafferri, A, Perci, R, Reuter, C, Schenk, D, Schumann, M, Towers, S

“…Radioactivity is understood to be described by a Poisson process, yet some measurements of nuclear decays appear to exhibit unexpected variations. Generally,…”
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P1940Reciprocal regulation of Endothelial-Mesenchymal Transition by MAPK7 and EZH2 activity in Intimal Hyperplasia and Coronary Artery Disease by Vanchin, B, Sol, M, Gjaltema, R A F, Van Der Pol, B, Brinker, M G L, Kiers, B, Pereira, A C, Harmsen, M C, Moonen, J A J, Krenning, G

“…Abstract Introduction Endothelial cells play a pivotal role in the formation of neointimal lesions by the acquisition of a fibro-proliferative phenotype…”
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