Search Results - "Giuseppina Sannino"

Epithelial-to-Mesenchymal and Mesenchymal-to-Epithelial Transition in Mesenchymal Tumors: A Paradox in Sarcomas? by Sannino, Giuseppina, Marchetto, Aruna, Kirchner, Thomas, Grünewald, Thomas G P

“…The epithelial-to-mesenchymal transition (EMT) is a reversible process comprised of various subprograms via which epithelial cells reduce their intercellular…”
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Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes by Musa, Julian, Cidre-Aranaz, Florencia, Aynaud, Marie-Ming, Orth, Martin F., Knott, Maximilian M. L., Mirabeau, Olivier, Mazor, Gal, Varon, Mor, Hölting, Tilman L. B., Grossetête, Sandrine, Gartlgruber, Moritz, Surdez, Didier, Gerke, Julia S., Ohmura, Shunya, Marchetto, Aruna, Dallmayer, Marlene, Baldauf, Michaela C., Stein, Stefanie, Sannino, Giuseppina, Li, Jing, Romero-Pérez, Laura, Westermann, Frank, Hartmann, Wolfgang, Dirksen, Uta, Gymrek, Melissa, Anderson, Nathaniel D., Shlien, Adam, Rotblat, Barak, Kirchner, Thomas, Delattre, Olivier, Grünewald, Thomas G. P.

“…Pediatric malignancies including Ewing sarcoma (EwS) feature a paucity of somatic alterations except for pathognomonic driver-mutations that cannot explain…”
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Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma by Marchetto, Aruna, Ohmura, Shunya, Orth, Martin F., Knott, Maximilian M. L., Colombo, Maria V., Arrigoni, Chiara, Bardinet, Victor, Saucier, David, Wehweck, Fabienne S., Li, Jing, Stein, Stefanie, Gerke, Julia S., Baldauf, Michaela C., Musa, Julian, Dallmayer, Marlene, Romero-Pérez, Laura, Hölting, Tilman L. B., Amatruda, James F., Cossarizza, Andrea, Henssen, Anton G., Kirchner, Thomas, Moretti, Matteo, Cidre-Aranaz, Florencia, Sannino, Giuseppina, Grünewald, Thomas G. P.

“…Ewing sarcoma (EwS) is an aggressive childhood cancer likely originating from mesenchymal stem cells or osteo-chondrogenic progenitors. It is characterized by…”
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Publisher Correction: Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma by Marchetto, Aruna, Ohmura, Shunya, Orth, Martin F., Knott, Maximilian M. L., Colombo, Maria V., Arrigoni, Chiara, Bardinet, Victor, Saucier, David, Wehweck, Fabienne S., Li, Jing, Stein, Stefanie, Gerke, Julia S., Baldauf, Michaela C., Musa, Julian, Dallmayer, Marlene, Romero-Pérez, Laura, Hölting, Tilman L. B., Amatruda, James F., Cossarizza, Andrea, Henssen, Anton G., Kirchner, Thomas, Moretti, Matteo, Cidre-Aranaz, Florencia, Sannino, Giuseppina, Grünewald, Thomas G. P.

“…A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-20017-2…”
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Robust diagnosis of Ewing sarcoma by immunohistochemical detection of super-enhancer-driven EWSR1-ETS targets by Baldauf, Michaela C, Orth, Martin F, Dallmayer, Marlene, Marchetto, Aruna, Gerke, Julia S, Rubio, Rebeca Alba, Kiran, Merve M, Musa, Julian, Knott, Maximilian M L, Ohmura, Shunya, Li, Jing, Akpolat, Nusret, Akatli, Ayse N, Özen, Özlem, Dirksen, Uta, Hartmann, Wolfgang, de Alava, Enrique, Baumhoer, Daniel, Sannino, Giuseppina, Kirchner, Thomas, Grünewald, Thomas G P

“…Ewing sarcoma is an undifferentiated small-round-cell sarcoma. Although molecular detection of pathognomonic fusions such as enables definitive diagnosis,…”
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Functional genomics identifies AMPD2 as a new prognostic marker for undifferentiated pleomorphic sarcoma by Orth, Martin F., Gerke, Julia S., Knösel, Thomas, Altendorf‐Hofmann, Annelore, Musa, Julian, Alba‐Rubio, Rebeca, Stein, Stefanie, Hölting, Tilman L. B., Cidre‐Aranaz, Florencia, Romero‐Pérez, Laura, Dallmayer, Marlene, Baldauf, Michaela C., Marchetto, Aruna, Sannino, Giuseppina, Knott, Maximilian M. L., Wehweck, Fabienne, Ohmura, Shunya, Li, Jing, Hakozaki, Michiyuki, Kirchner, Thomas, Dandekar, Thomas, Butt, Elke, Grünewald, Thomas G. P.

“…Soft‐tissue sarcomas are rare, heterogeneous, and often aggressive mesenchymal cancers. Many of them are associated with poor outcome, partially because…”
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Focal adhesion kinase confers pro‐migratory and antiapoptotic properties and is a potential therapeutic target in Ewing sarcoma by Steinestel, Konrad, Trautmann, Marcel, Jansen, Esther‐Pia, Dirksen, Uta, Rehkämper, Jan, Mikesch, Jan‐Henrik, Gerke, Julia S., Orth, Martin F., Sannino, Giuseppina, Arteaga, Maria‐Francisca, Rossig, Claudia, Wardelmann, Eva, Grünewald, Thomas G. P., Hartmann, Wolfgang

“…Oncogenesis of Ewing sarcoma (EwS), the second most common malignant bone tumor of childhood and adolescence, is dependent on the expression of chimeric…”
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Targeting the CALCB/RAMP1 axis inhibits growth of Ewing sarcoma by Dallmayer, Marlene, Li, Jing, Ohmura, Shunya, Alba Rubio, Rebeca, Baldauf, Michaela C., Hölting, Tilman L. B., Musa, Julian, Knott, Max M. L., Stein, Stefanie, Cidre-Aranaz, Florencia, Wehweck, Fabienne S., Romero-Pérez, Laura, Gerke, Julia S., Orth, Martin F., Marchetto, Aruna, Kirchner, Thomas, Bach, Horacio, Sannino, Giuseppina, Grünewald, Thomas G. P.

“…Ewing sarcoma (EwS) is an aggressive cancer characterized by chromosomal translocations generating fusions of the EWSR1 gene with ETS transcription factors (in…”
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Acute stress enhances the expression of neuroprotection- and neurogenesis-associated genes in the hippocampus of a mouse restraint model by Sannino, Giuseppina, Pasqualini, Lorenza, Ricciardelli, Eugenia, Montilla, Patricia, Soverchia, Laura, Ruggeri, Barbara, Falcinelli, Silvia, Renzi, Alessandra, Ludka, Colleen, Kirchner, Thomas, Grünewald, Thomas G P, Ciccocioppo, Roberto, Ubaldi, Massimo, Hardiman, Gary

“…Stress arises from an external demand placed on an organism that triggers physiological, cognitive and behavioural responses in order to cope with that…”
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Systematic identification of cancer-specific MHC-binding peptides with RAVEN by Baldauf, Michaela C., Gerke, Julia S., Kirschner, Andreas, Blaeschke, Franziska, Effenberger, Manuel, Schober, Kilian, Rubio, Rebeca Alba, Kanaseki, Takayuki, Kiran, Merve M., Dallmayer, Marlene, Musa, Julian, Akpolat, Nurset, Akatli, Ayse N., Rosman, Fernando C., Özen, Özlem, Sugita, Shintaro, Hasegawa, Tadashi, Sugimura, Haruhiko, Baumhoer, Daniel, Knott, Maximilian M. L., Sannino, Giuseppina, Marchetto, Aruna, Li, Jing, Busch, Dirk H., Feuchtinger, Tobias, Ohmura, Shunya, Orth, Martin F., Thiel, Uwe, Kirchner, Thomas, Grünewald, Thomas G. P.

“…Immunotherapy can revolutionize anti-cancer therapy if specific targets are available. Immunogenic peptides encoded by cancer-specific genes (CSGs) may enable…”
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P1169NUTRITIONAL STATUS OF PATIENTS IN PERITONEAL DIALYSIS: TWO METHODS COMPARED by Paribello, Giuseppe, Di Gruttola, Oto, Paduano, Immacolata Gaia, Migliaccio, Silvia, Argentino, Gennaro, Sannino, Giuseppina, Russo, Domenico

“…Abstract Background and Aims Nutritional status and survival are closely related: a state of undernutrition favors the onset of fatal and non-fatal events…”
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P1192METABOLIC SYNDROME IN PATIENTS UNDERGOING PERITONEAL DIALYSIS (PD): A SINGLE CENTER EXPERIENCE by Di Gruttola, Oto, Paribello, Giuseppe, Paduano, Immacolata Gaia, Migliaccio, Silvia, Argentino, Gennaro, Sannino, Giuseppina, Russo, Domenico

“…Abstract Background and Aims Metabolic syndrome (MS) is a set of alterations represents a cluster of risk factors that increase the probability of causing…”
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Simultaneous abdominal wall defect repair and Tenckhoff catheter placement in candidates for peritoneal dialysis by Sodo, Maurizio, Bracale, Umberto, Argentino, Gennaro, Merola, Giovanni, Russo, Roberta, Sannino, Giuseppina, Strazzullo, Tania, Russo, Domenico

“…Introduction The presence of pre-existing abdominal wall defect (AWD) could represent a potential contraindication for peritoneal dialysis (PD) treatment. We…”
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Role of BCL9L in transforming growth factor-β (TGF-β)-induced epithelial-to-mesenchymal-transition (EMT) and metastasis of pancreatic cancer by Sannino, Giuseppina, Armbruster, Nicole, Bodenhöfer, Mona, Haerle, Ursula, Behrens, Diana, Buchholz, Malte, Rothbauer, Ulrich, Sipos, Bence, Schmees, Christian

“…Pancreatic ductal adenocarcinoma (PDAC) has a low overall survival rate, which is approximately 20% during the first year and decreases to less than 6% within…”
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Integrative clinical transcriptome analysis reveals TMPRSS2‐ERG dependency of prognostic biomarkers in prostate adenocarcinoma by Gerke, Julia S., Orth, Martin F., Tolkach, Yuri, Romero‐Pérez, Laura, Wehweck, Fabienne S., Stein, Stefanie, Musa, Julian, Knott, Maximilian M.L., Hölting, Tilman L.B., Li, Jing, Sannino, Giuseppina, Marchetto, Aruna, Ohmura, Shunya, Cidre‐Aranaz, Florencia, Müller‐Nurasyid, Martina, Strauch, Konstantin, Stief, Christian, Kristiansen, Glen, Kirchner, Thomas, Buchner, Alexander, Grünewald, Thomas G.P.

“…In prostate adenocarcinoma (PCa), distinction between indolent and aggressive disease is challenging. Around 50% of PCa are characterized by TMPRSS2‐ERG…”
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Next steps in Ewing sarcoma (epi-)genomics by Sannino, Giuseppina, Orth, Martin F, Grünewald, Thomas GP

“…[...]more copy number variations were found in EwS with STAG2-mutation (6). Besides GGAA-mSats, also germline variation in the exome may contribute to the…”
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Biomarkers of hippocampal gene expression in a mouse restraint chronic stress model by Ubaldi, Massimo, Ricciardelli, Eugenia, Pasqualini, Lorenza, Sannino, Giuseppina, Soverchia, Laura, Ruggeri, Barbara, Falcinelli, Silvia, Renzi, Alessandra, Ludka, Colleen, Ciccocioppo, Roberto, Hardiman, Gary

“…Acute stress provides many beneficial effects whereas chronic stress contributes to a variety of human health issues including anxiety, depression,…”
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Gene expression and immunohistochemical analyses identify SOX2 as major risk factor for overall survival and relapse in Ewing sarcoma patients by Sannino, Giuseppina, Marchetto, Aruna, Ranft, Andreas, Jabar, Susanne, Zacherl, Constanze, Alba-Rubio, Rebeca, Stein, Stefanie, Wehweck, Fabienne S., Kiran, Merve M., Hölting, Tilman L.B., Musa, Julian, Romero-Pérez, Laura, Cidre-Aranaz, Florencia, Knott, Maximilian M.L., Li, Jing, Jürgens, Heribert, Sastre, Ana, Alonso, Javier, Da Silveira, Willian, Hardiman, Gary, Gerke, Julia S., Orth, Martin F., Hartmann, Wolfgang, Kirchner, Thomas, Ohmura, Shunya, Dirksen, Uta, Grünewald, Thomas G.P.

“…Up to 30–40% of Ewing sarcoma (EwS) patients with non-metastatic disease develop local or metastatic relapse within a time span of 2–10 years. This is in part…”
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Developmental and extracellular matrix-remodeling processes in rosiglitazone-exposed neonatal rat cardiomyocytes by Paolini, Paul, Pick, Daniel, Lapira, Jennifer, Sannino, Giuseppina, Pasqualini, Lorenza, Ludka, Colleen, Sprague, L James, Zhang, Xian, Bartolotta, Elesha A, Vazquez-Hidalgo, Esteban, Barba, David Torres, Bazan, Carlos, Hardiman, Gary

“…The objective of this study was to investigate the effects of rosiglitazone (Avandia(®)) on gene expression in neonatal rat ventricular myocytes. Myocytes were…”
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Gene expression and immunohistochemical analyses identify SOX2 as major risk factor for overall survival and relapse in Ewing sarcoma patientsResearch in context by Giuseppina Sannino, Aruna Marchetto, Andreas Ranft, Susanne Jabar, Constanze Zacherl, Rebeca Alba-Rubio, Stefanie Stein, Fabienne S. Wehweck, Merve M. Kiran, Tilman L.B. Hölting, Julian Musa, Laura Romero-Pérez, Florencia Cidre-Aranaz, Maximilian M.L. Knott, Jing Li, Heribert Jürgens, Ana Sastre, Javier Alonso, Willian Da Silveira, Gary Hardiman, Julia S. Gerke, Martin F. Orth, Wolfgang Hartmann, Thomas Kirchner, Shunya Ohmura, Uta Dirksen, Thomas G.P. Grünewald

“…Background: Up to 30–40% of Ewing sarcoma (EwS) patients with non-metastatic disease develop local or metastatic relapse within a time span of 2–10 years. This…”
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