Search Results - "Giuseppe Caruso"

Unveiling the Hidden Therapeutic Potential of Carnosine, a Molecule with a Multimodal Mechanism of Action: A Position Paper by Caruso, Giuseppe

“…Carnosine (β-alanyl-L-histidine) is a naturally occurring endogenous dipeptide and an over-the-counter food supplement with a well-demonstrated multimodal…”
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Editorial: Microfluidics and mass spectrometry in drug discovery and development: from synthesis to evaluation by Caruso, Giuseppe

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Pivotal role of carnosine in the modulation of brain cells activity: Multimodal mechanism of action and therapeutic potential in neurodegenerative disorders by Caruso, Giuseppe, Caraci, Filippo, Jolivet, Renaud B

“…Carnosine (β-alanyl-l-histidine), a dipeptide, is an endogenous antioxidant widely distributed in excitable tissues like muscles and the brain. Although…”
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A Path Toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer's Disease by Hampel, Harald, Caraci, Filippo, Cuello, A Claudio, Caruso, Giuseppe, Nisticò, Robert, Corbo, Massimo, Baldacci, Filippo, Toschi, Nicola, Garaci, Francesco, Chiesa, Patrizia A, Verdooner, Steven R, Akman-Anderson, Leyla, Hernández, Félix, Ávila, Jesús, Emanuele, Enzo, Valenzuela, Pedro L, Lucía, Alejandro, Watling, Mark, Imbimbo, Bruno P, Vergallo, Andrea, Lista, Simone

“…Neuroinflammation commences decades before Alzheimer's disease (AD) clinical onset and represents one of the earliest pathomechanistic alterations throughout…”
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Phenolic Acids and Prevention of Cognitive Decline: Polyphenols with a Neuroprotective Role in Cognitive Disorders and Alzheimer's Disease by Caruso, Giuseppe, Godos, Justyna, Privitera, Anna, Lanza, Giuseppe, Castellano, Sabrina, Chillemi, Alessio, Bruni, Oliviero, Ferri, Raffaele, Caraci, Filippo, Grosso, Giuseppe

“…Cognitive impairment, also known as cognitive decline, can occur gradually or suddenly and can be temporary or more permanent. It represents an increasingly…”
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Facing EL teachers' burnout through motivation by Caruso, Giuseppe

“…The educational institutions in many countries are faced with the major problem of teacher burnout causing high rates of attrition and absenteeism. There is…”
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Time Evolution of Nanoparticle–Protein Corona in Human Plasma: Relevance for Targeted Drug Delivery by Barrán-Berdón, Ana Lilia, Pozzi, Daniela, Caracciolo, Giulio, Capriotti, Anna Laura, Caruso, Giuseppe, Cavaliere, Chiara, Riccioli, Anna, Palchetti, Sara, Laganà, Aldo

“…When nanoparticles (NPs) enter a biological fluid (e.g., human plasma (HP)), proteins and other biomolecules adsorb on the surface leading to formation of a…”
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Identification of potential bioactive peptides generated by simulated gastrointestinal digestion of soybean seeds and soy milk proteins by Capriotti, Anna Laura, Caruso, Giuseppe, Cavaliere, Chiara, Samperi, Roberto, Ventura, Salvatore, Zenezini Chiozzi, Riccardo, Laganà, Aldo

“…•Simulated gastrointestinal digestion study of proteins from soybean seeds and milk.•Effect of protein purification on the gastrointestinal digestion output of…”
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Gap Junctions and Connexins in Microglia-Related Oxidative Stress and Neuroinflammation: Perspectives for Drug Discovery by Caruso, Giuseppe, Di Pietro, Lucia, Caraci, Filippo

“…Microglia represent the immune system of the brain. Their role is central in two phenomena, neuroinflammation and oxidative stress, which are at the roots of…”
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Antioxidant Properties of Second-Generation Antipsychotics: Focus on Microglia by Caruso, Giuseppe, Grasso, Margherita, Fidilio, Annamaria, Tascedda, Fabio, Drago, Filippo, Caraci, Filippo

“…Recent studies suggest a primary role of oxidative stress in an early phase of the pathogenesis of schizophrenia and a strong neurobiological link has been…”
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Mediterranean diet, mental health, cognitive status, quality of life, and successful aging in southern Italian older adults by Godos, Justyna, Grosso, Giuseppe, Ferri, Raffaele, Caraci, Filippo, Lanza, Giuseppe, Al-Qahtani, Wahidah H., Caruso, Giuseppe, Castellano, Sabrina

“…Healthy successful aging with preserved mental and cognitive health is expected to be one of the most important challenges of the growing old population…”
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Modulation of Pro-Oxidant and Pro-Inflammatory Activities of M1 Macrophages by the Natural Dipeptide Carnosine by Fresta, Claudia G, Fidilio, Annamaria, Lazzarino, Giacomo, Musso, Nicolò, Grasso, Margherita, Merlo, Sara, Amorini, Angela M, Bucolo, Claudio, Tavazzi, Barbara, Lazzarino, Giuseppe, Lunte, Susan M, Caraci, Filippo, Caruso, Giuseppe

“…Carnosine is a natural endogenous dipeptide widely distributed in mammalian tissues, existing at particularly high concentrations in the muscles and brain and…”
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A New Human Blood-Retinal Barrier Model Based on Endothelial Cells, Pericytes, and Astrocytes by Fresta, Claudia G, Fidilio, Annamaria, Caruso, Giuseppe, Caraci, Filippo, Giblin, Frank J, Leggio, Gian Marco, Salomone, Salvatore, Drago, Filippo, Bucolo, Claudio

“…Blood-retinal barrier (BRB) dysfunction represents one of the most significant changes occurring during diabetic retinopathy. We set up a high-reproducible…”
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The Therapeutic Potential of Carnosine as an Antidote against Drug-Induced Cardiotoxicity and Neurotoxicity: Focus on Nrf2 Pathway by Caruso, Giuseppe, Privitera, Anna, Antunes, Barbara Moura, Lazzarino, Giuseppe, Lunte, Susan Marie, Aldini, Giancarlo, Caraci, Filippo

“…Different drug classes such as antineoplastic drugs (anthracyclines, cyclophosphamide, 5-fluorouracil, taxanes, tyrosine kinase inhibitors), antiretroviral…”
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Association between Time Restricted Feeding and Cognitive Status in Older Italian Adults by Currenti, Walter, Godos, Justyna, Castellano, Sabrina, Caruso, Giuseppe, Ferri, Raffaele, Caraci, Filippo, Grosso, Giuseppe, Galvano, Fabio

“…Due to the increased life expectancy, the prevalence of aging-related health conditions, such as cognitive impairment, dementia and Alzheimer's disease is…”
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Biodiversity as a Tool in the Assessment of the Conservation Status of Coastal Habitats: A Case Study from Calabria (Southern Italy) by Morabito, Antonio, Musarella, Carmelo Maria, Caruso, Giuseppe, Spampinato, Giovanni

“…The Mediterranean coasts are threatened by human activities that alter habitats structure and functionality, modifying vegetation and causing the loss of…”
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Impact of Proto-Oncogene Mutation Detection in Cytological Specimens from Thyroid Nodules Improves the Diagnostic Accuracy of Cytology by Cantara, Silvia, Capezzone, Marco, Marchisotta, Stefania, Capuano, Serena, Busonero, Giulia, Toti, Paolo, Di Santo, Andrea, Caruso, Giuseppe, Carli, Anton Ferdinando, Brilli, Lucia, Montanaro, Annalisa, Pacini, Furio

“…Context: Fine-needle aspiration cytology (FNAC) is the gold standard for the differential diagnosis of thyroid nodules but has the limitation of inadequate…”
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Antidepressant Drugs and Physical Activity: A Possible Synergism in the Treatment of Major Depression? by Guerrera, Claudia Savia, Furneri, Giovanna, Grasso, Margherita, Caruso, Giuseppe, Castellano, Sabrina, Drago, Filippo, Di Nuovo, Santo, Caraci, Filippo

“…Major depressive disorder (MDD) is a severe mental illness that affects 5-20% of the general population. Current antidepressant drugs exert only a partial…”
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Fluoxetine and Vortioxetine Reverse Depressive-Like Phenotype and Memory Deficits Induced by Aβ1-42 Oligomers in Mice: A Key Role of Transforming Growth Factor-β1 by Torrisi, Sebastiano Alfio, Geraci, Federica, Tropea, Maria Rosaria, Grasso, Margherita, Caruso, Giuseppe, Fidilio, Annamaria, Musso, Nicolò, Sanfilippo, Giulia, Tascedda, Fabio, Palmeri, Agostino, Salomone, Salvatore, Drago, Filippo, Puzzo, Daniela, Leggio, Gian Marco, Caraci, Filippo

“…Depression is a risk factor for the development of Alzheimer’s disease (AD), and the presence of depressive symptoms significantly increases the conversion of…”
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Altered Follicular Fluid Metabolic Pattern Correlates with Female Infertility and Outcome Measures of In Vitro Fertilization by Lazzarino, Giacomo, Pallisco, Romina, Bilotta, Gabriele, Listorti, Ilaria, Mangione, Renata, Saab, Miriam Wissam, Caruso, Giuseppe, Amorini, Angela Maria, Brundo, Maria Violetta, Lazzarino, Giuseppe, Tavazzi, Barbara, Bilotta, Pasquale

“…Nearly 40-50% of infertility problems are estimated to be of female origin. Previous studies dedicated to the analysis of metabolites in follicular fluid (FF)…”
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