Search Results - "Giuliani, Elizabeth A"

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice by Kohl, Nancy E, Omer, Charles A, Conner, Michael W, Anthony, Neville J, Davide, Joseph P, Desolms, S. Jane, Giuliani, Elizabeth A, Gomez, Robert P, Graham, Samuel L, Hamilton, Kelly, Handt, Laurence K, Hartman, George D, Koblan, Kenneth S, Kral, Astrid M, Miller, Patricia J, Mosser, Scott D, O'Neill, Timothy J, Rands, Elaine, Schaber, Michael D, Gibbs, Jackson B, Oliff, Allen

“…For Ras oncoproteins to transform mammalian cells, they must be post-translationally modified with a farnesyl group in a reaction catalysed by the enzyme…”
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Pseudopeptide Inhibitors of Ras Farnesyl-Protein Transferase by Graham, Samuel L, deSolms, S. Jane, Giuliani, Elizabeth A, Kohl, Nancy E, Mosser, Scott D, Oliff, Allen I, Pompliano, David L, Rands, Elaine, Breslin, Michael J

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A series of potent HIV-1 protease inhibitors containing a hydroxyethyl secondary amine transition state isostere: synthesis, enzyme inhibition, and antiviral activity by Tucker, Thomas J, Lumma, William C, Payne, Linda S, Wai, Jenny M, De Solms, S. Jane, Giuliani, Elizabeth A, Darke, Paul L, Heimbach, Jill C, Zugay, Joan A

“…A series of HIV-1 protease inhibitors containing a novel hydroxyethyl secondary amine transition state isostere has been synthesized. The compounds exhibit a…”
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N-Arylalkyl Pseudopeptide Inhibitors of Farnesyltransferase by deSolms, S. Jane, Giuliani, Elizabeth A, Graham, Samuel L, Koblan, Kenneth S, Kohl, Nancy E, Mosser, Scott D, Oliff, Allen I, Pompliano, David L, Rands, Elaine, Scholz, Thomas H, Wiscount, Catherine M, Gibbs, Jackson B, Smith, Robert L

“…Inhibitors of Ras protein farnesyltransferase are described which are reduced pseudopeptides related to the C-terminal tetrapeptide of the Ras protein that…”
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Pseudodipeptide Inhibitors of Protein Farnesyltransferase by deSolms, S. Jane, Deana, Albert A, Giuliani, Elizabeth A, Graham, Samuel L, Kohl, Nancy E, Mosser, Scott D, Oliff, Allen I, Pompliano, David L, Rands, Elaine

“…A series of pseudodipeptide amides are described that inhibit Ras protein farnesyltransferase (PFTase). These inhibitors are truncated versions of the…”
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A Priori Prediction of Activity for HIV-1 Protease Inhibitors Employing Energy Minimization in the Active Site by Holloway, M. Katharine, Wai, Jenny M, Halgren, Thomas A, Fitzgerald, Paula M. D, Vacca, Joseph P, Dorsey, Bruce D, Levin, Rhonda B, Thompson, Wayne J, Chen, L. Jenny, deSolms, S. Jane, Gaffin, Neil, Ghosh, Arun K, Giuliani, Elizabeth A, Graham, Samuel L, Guare, James P, Hungate, Randall W, Lyle, Terry A, Sanders, William M, Tucker, Thomas J, Wiggins, Mark, Wiscount, Catherine M, Woltersdorf, Otto W, Young, Steven D, Darke, Paul L, Zugay, Joan A

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Design and synthesis of HIV protease inhibitors. Variations of the carboxyterminus of the HIV protease inhibitor L-682,679 by DeSolms, S. Jane, Giuliani, Elizabeth A, Guare, James P, Vacca, Joseph P, Sanders, William M, Graham, Samuel L, Wiggins, J. Mark, Darke, Paul L, Sigal, Irving S

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Selective Inhibition of ras-Dependent Transformation by a Farnesyltransferase Inhibitor by Kohl, Nancy E., Mosser, Scott D., deSolms, S. Jane, Giuliani, Elizabeth A., Pompliano, David L., Graham, Samuel L., Smith, Robert L., Scolnick, Edward M., Oliff, Allen, Gibbs, Jackson B.

“…To acquire transforming potential, the precursor of the Ras oncoprotein must undergo farnesylation of the cysteine residue located in a carboxyl-terminal…”
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Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton by Prendergast, G C, Davide, J P, deSolms, S J, Giuliani, E A, Graham, S L, Gibbs, J B, Oliff, A, Kohl, N E

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Potent, non-thiol inhibitors of farnesyltransferase by Breslin, Michael J., deSolms, S.Jane, Giuliani, Elizabeth A., Stokker, Gerald E., Graham, Samuel L., Pompliano, David L., Mosser, Scott D., Hamilton, Kelly A., Hutchinson, John H.

“…The structure-activity relationship of a series of non-thiol CaaX analogs, which are inhibitors of farnesyltransferase, is described. These inhibitors contain…”
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NMR studies of novel inhibitors bound to farnesyl‐protein transferase by Koblan, Kenneth S., Mosser, Scott D., Omer, Charles A., Christopher Culberson, J., Jane Desolms, S., Giuliani, Elizabeth A., Pitzenberger, Steven M., Bogusky, Michael J.

“…Farnesyl‐protein transferase (FPTase) catalyzes the posttranslational farnesylation of the cysteine residue located in the carboxyl‐terminal tetrapeptide of…”
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Design and synthesis of HIV protease inhibitors. Variations of the carboxy terminus of the HIV protease inhibitor L-682,679 by DESOLMS, S. J, GIULIANI, E. A, EMINI, E. A, SCHLEIF, W. A, QUINTERO, J. C, ANDERSON, P. S, HUFF, J. R, GUARE, J. P, VACCA, J. P, SANDERS, W. M, GRAHAM, S. L, WIGGINS, J. M, DARKE, P. L, SIGAL, I. S, ZUGAY, J. A

“…A series of tetrapeptide analogues of 1 (L-682,679), in which the carboxy terminus has been shortened and modified, was prepared and their inhibitory activity…”
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Selection inhibition of ras-dependent transformation by a farnesyltransferase inhibitor by Kohl, Nancy E, Mosser, Scott D, DeSolms, S. Jane, Giuliani, Elizabeth A, Pompliano, David L, Smith, Robert L, Scolnick, Edward M, Oliff, Allen, Gibbs, Jackson B

“…To acquire transforming potential, the precursor of the Ras oncoprotein must undergo farnesylation of the cysteine residue located in a carboxyl-terminal…”
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Farnesyltransferase Inhibition Causes Morphological Reversion of ras-Transformed Cells by a Complex Mechanism That Involves Regulation of the Actin Cytoskeleton by Prendergast, George C., Da Vide, Joseph P., Desolms, S. Jane, Giuliani, Elizabeth A., Graham, Samuel L., Gibbs, Jackson B., Oliff, Allen, Kohl, Nancy E.

“…A potent and specific small molecule inhibitor of farnesyl-protein transferase, L-739,749, caused rapid morphological reversion and growth inhibition of…”
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