Search Results - "Giuliani, E. A"

Selective Inhibition of ras-Dependent Transformation by a Farnesyltransferase Inhibitor by Kohl, Nancy E., Mosser, Scott D., deSolms, S. Jane, Giuliani, Elizabeth A., Pompliano, David L., Graham, Samuel L., Smith, Robert L., Scolnick, Edward M., Oliff, Allen, Gibbs, Jackson B.

“…To acquire transforming potential, the precursor of the Ras oncoprotein must undergo farnesylation of the cysteine residue located in a carboxyl-terminal…”
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Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton by Prendergast, G C, Davide, J P, deSolms, S J, Giuliani, E A, Graham, S L, Gibbs, J B, Oliff, A, Kohl, N E

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L-687,908, a potent hydroxyethylene containing HIV protease inhibitor by Vacca, Joseph P, Guare, J. P, DeSolms, S. J, Sanders, W. M, Giuliani, E. A, Young, S. D, Darke, P. L, Sigal, I. S, Schleif, W. A

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Potent, non-thiol inhibitors of farnesyltransferase by Breslin, Michael J., deSolms, S.Jane, Giuliani, Elizabeth A., Stokker, Gerald E., Graham, Samuel L., Pompliano, David L., Mosser, Scott D., Hamilton, Kelly A., Hutchinson, John H.

“…The structure-activity relationship of a series of non-thiol CaaX analogs, which are inhibitors of farnesyltransferase, is described. These inhibitors contain…”
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N-Arylalkyl Pseudopeptide Inhibitors of Farnesyltransferase by deSolms, S. Jane, Giuliani, Elizabeth A, Graham, Samuel L, Koblan, Kenneth S, Kohl, Nancy E, Mosser, Scott D, Oliff, Allen I, Pompliano, David L, Rands, Elaine, Scholz, Thomas H, Wiscount, Catherine M, Gibbs, Jackson B, Smith, Robert L

“…Inhibitors of Ras protein farnesyltransferase are described which are reduced pseudopeptides related to the C-terminal tetrapeptide of the Ras protein that…”
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NMR studies of novel inhibitors bound to farnesyl‐protein transferase by Koblan, Kenneth S., Mosser, Scott D., Omer, Charles A., Christopher Culberson, J., Jane Desolms, S., Giuliani, Elizabeth A., Pitzenberger, Steven M., Bogusky, Michael J.

“…Farnesyl‐protein transferase (FPTase) catalyzes the posttranslational farnesylation of the cysteine residue located in the carboxyl‐terminal tetrapeptide of…”
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Pseudodipeptide Inhibitors of Protein Farnesyltransferase by deSolms, S. Jane, Deana, Albert A, Giuliani, Elizabeth A, Graham, Samuel L, Kohl, Nancy E, Mosser, Scott D, Oliff, Allen I, Pompliano, David L, Rands, Elaine

“…A series of pseudodipeptide amides are described that inhibit Ras protein farnesyltransferase (PFTase). These inhibitors are truncated versions of the…”
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A series of potent HIV-1 protease inhibitors containing a hydroxyethyl secondary amine transition state isostere: synthesis, enzyme inhibition, and antiviral activity by Tucker, Thomas J, Lumma, William C, Payne, Linda S, Wai, Jenny M, De Solms, S. Jane, Giuliani, Elizabeth A, Darke, Paul L, Heimbach, Jill C, Zugay, Joan A

“…A series of HIV-1 protease inhibitors containing a novel hydroxyethyl secondary amine transition state isostere has been synthesized. The compounds exhibit a…”
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Design and synthesis of HIV protease inhibitors. Variations of the carboxy terminus of the HIV protease inhibitor L-682,679 by DESOLMS, S. J, GIULIANI, E. A, EMINI, E. A, SCHLEIF, W. A, QUINTERO, J. C, ANDERSON, P. S, HUFF, J. R, GUARE, J. P, VACCA, J. P, SANDERS, W. M, GRAHAM, S. L, WIGGINS, J. M, DARKE, P. L, SIGAL, I. S, ZUGAY, J. A

“…A series of tetrapeptide analogues of 1 (L-682,679), in which the carboxy terminus has been shortened and modified, was prepared and their inhibitory activity…”
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A priori prediction of activity for HIV-1 protease inhibitors employing energy minimization in the active site by Holloway, M. Katharine, Wai, Jenny M, Halgren, Thomas A, Fitzgerald, Paula M. D, Vacca, Joseph P, Dorsey, Bruce D, Levin, Rhonda B, Thompson, Wayne J, Chen, L. Jenny

“…We have observed a high correlation between the intermolecular interaction energy (Einter) calculated for HIV-1 protease inhibitor complexes and the observed…”
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Pseudopeptide inhibitors of Ras farnesyl-protein transferase by Graham, S L, deSolms, S J, Giuliani, E A, Kohl, N E, Mosser, S D, Oliff, A I, Pompliano, D L, Rands, E, Breslin, M J, Deana, A A

“…Inhibitors of Ras farnesyl-protein transferase are described. These are reduced pseudopeptides related to the C-terminal tetrapeptide of the Ras protein that…”
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Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice by Kohl, Nancy E, Omer, Charles A, Conner, Michael W, Anthony, Neville J, Davide, Joseph P, Desolms, S. Jane, Giuliani, Elizabeth A, Gomez, Robert P, Graham, Samuel L, Hamilton, Kelly, Handt, Laurence K, Hartman, George D, Koblan, Kenneth S, Kral, Astrid M, Miller, Patricia J, Mosser, Scott D, O'Neill, Timothy J, Rands, Elaine, Schaber, Michael D, Gibbs, Jackson B, Oliff, Allen

“…For Ras oncoproteins to transform mammalian cells, they must be post-translationally modified with a farnesyl group in a reaction catalysed by the enzyme…”
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Mapping a pathway for axillary staging: a personal perspective on the current status of sentinel lymph node dissection for breast cancer by Giuliano, A E

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Patterns of myocardial endothelin-1 expression and outcome after cardiac transplantation by FERRI, Claudio, PROPERZI, Giuliana, YOUNG, James B, YAMANI, Mohamad H, TOMASSONI, Gianluca, SANTUCCI, Anna, DESIDERI, Giovambattista, GIULIANI, Anna Elisa, STARLING, Randall C, RATLIFF, Norman B, COOK, Daniel J, MCCARTHY, Patrick

“…Endothelin-1 (ET-1), a potent vasoconstrictor, is released in response to several inflammatory cytokines after heart transplantation. The present study…”
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Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involved regulation of the actin cytoskeleton by PRENDERGAST, G. C, DAVIDE, J. P, DESOLMS, S. J, GIULIANI, E. A, GRAHMA, S. L, GIBBS, J. B, OLIFF, A, KOHL, N. E

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A Priori Prediction of Activity for HIV-1 Protease Inhibitors Employing Energy Minimization in the Active Site by Holloway, M. Katharine, Wai, Jenny M, Halgren, Thomas A, Fitzgerald, Paula M. D, Vacca, Joseph P, Dorsey, Bruce D, Levin, Rhonda B, Thompson, Wayne J, Chen, L. Jenny, deSolms, S. Jane, Gaffin, Neil, Ghosh, Arun K, Giuliani, Elizabeth A, Graham, Samuel L, Guare, James P, Hungate, Randall W, Lyle, Terry A, Sanders, William M, Tucker, Thomas J, Wiggins, Mark, Wiscount, Catherine M, Woltersdorf, Otto W, Young, Steven D, Darke, Paul L, Zugay, Joan A

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