Search Results - "Giuffredi, Guy T"

Organocatalyzed Enantioselective Fluorocyclizations by Lozano, Oscar, Blessley, George, Martinez del Campo, Teresa, Thompson, Amber L., Giuffredi, Guy T., Bettati, Michela, Walker, Matthew, Borman, Richard, Gouverneur, Véronique

“…Enantioenriched fluorinated heterocycles can be prepared through fluorocyclizations of prochiral indoles (see scheme; Ts=tosyl, Bn=benzyl,…”
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Coordination diversity in hydrogen-bonded homoleptic fluoride-alcohol complexes modulates reactivity by Engle, Keary M, Pfeifer, Lukas, Pidgeon, George W, Giuffredi, Guy T, Thompson, Amber L, Paton, Robert S, Brown, John M, Gouverneur, Véronique

“…The nucleophilic reactivity of fluoride ion is altered in the presence of hydrogen-bond donors, including alcohols. Relatively little is known about the…”
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Gold-Catalyzed Intramolecular Oxidative Cross-Coupling of Nonactivated Arenes by Hopkinson, Matthew N., Tessier, Arnaud, Salisbury, Andrew, Giuffredi, Guy T., Combettes, Lorraine E., Gee, Antony D., Gouverneur, Véronique

“…An (Au)some coupling! Gold‐catalyzed cascade CO cyclizations of benzyl‐substituted allenoate esters followed by intramolecular oxidative CC cross‐coupling…”
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Intramolecular Schmidt Reaction Involving Primary Azidoalcohols under Nonacidic Conditions: Synthesis of Indolizidine (−)-167B by Kapat, Ajoy, Nyfeler, Erich, Giuffredi, Guy T, Renaud, Philippe

“…A powerful intramolecular Schmidt reaction starting from primary azidoalcohols is reported. This approach involves a nonacidic activation of the alcohol via…”
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Diastereoselective Synthesis of P-Stereogenic Heterocycles via Enyne Ring-Closing Metathesis by Harvey, James Stephen, Giuffredi, Guy T, Gouverneur, Véronique

“…A range of P-containing ene-diynes suitable for desymmetrization was prepared via a two-step process starting from phosphorus oxychloride. In the presence of…”
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Intramolecular OH⋅⋅⋅FC Hydrogen Bonding in Fluorinated Carbohydrates: CHF is a Better Hydrogen Bond Acceptor than CF2 by Giuffredi, Guy T., Gouverneur, Véronique, Bernet, Bruno

“…An intramolecular bifurcated H‐bond from the axial HO‐2 group to the axial F‐4 atom and to the O5 atom of α‐D‐hexopyranosides in apolar solvents is evidenced…”
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Gold-Catalyzed Cascade Cyclization−Oxidative Alkynylation of Allenoates by Hopkinson, Matthew N, Ross, Jonathan E, Giuffredi, Guy T, Gee, Antony D, Gouverneur, Véronique

“…A gold(I)-catalyzed cascade cyclization−oxidative cross-coupling process has been applied to prepare β-alkynyl-γ-butenolides directly from allenoates and…”
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Identifying Lysophosphatidic Acid Acyltransferase β (LPAAT‐β) as the Target of a Nanomolar Angiogenesis Inhibitor from a Phenotypic Screen Using the Polypharmacology Browser PPB2 by Poirier, Marion, Awale, Mahendra, Roelli, Matthias A., Giuffredi, Guy T., Ruddigkeit, Lars, Evensen, Lasse, Stooss, Amandine, Calarco, Serafina, Lorens, James B., Charles, Roch‐Philippe, Reymond, Jean‐Louis

“…By screening a focused library of kinase inhibitor analogues in a phenotypic co‐culture assay for angiogenesis inhibition, we identified an aminotriazine that…”
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De Novo Synthesis of Racemic 4-Deoxy-4,4-difluoro- and 2,4-Dideoxy-2,4,4-trifluorohexosides by Giuffredi, Guy T., Bernet, Bruno, Gouverneur, Véronique

“…A range of racemic 4‐deoxy‐4,4‐difluorinated carbohydrates were prepared by using a diversity‐oriented de novo synthesis starting with three commercially…”
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Organocatalyzed Enantioselective Fluorocyclizations by Lozano, Oscar, Blessley, George, Martinez del Campo, Teresa, Thompson, Amber L., Giuffredi, Guy T., Bettati, Michela, Walker, Matthew, Borman, Richard, Gouverneur, Véronique

“…Enantiomerenangereicherte fluorierte Heterocyclen können durch Fluorcyclisierungen prochiraler Indole hergestellt werden (siehe Schema; Ts=Tosyl, Bn= Benzyl,…”
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Facile synthesis of 4-deoxy-4-fluoro-α- d-talopyranoside, 4-deoxy-4-fluoro-α- d-idopyranoside and 2,4-dideoxy-2,4-difluoro-α- d-talopyranoside by Giuffredi, Guy T., Jennings, Laura E., Bernet, Bruno, Gouverneur, Véronique

“…4-Deoxy-4-fluoro-α- d-idopyranosides and 2,4-dideoxy-2,4-difluoro-α- d-talopyranosides were prepared in two independent syntheses, in good yields from…”
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Synthesis and O-phosphorylation of 3,3,4,4-tetrafluoroaryl-C-nucleoside analogues by Bonnac, Laurent, Lee, Sarah E, Giuffredi, Guy T, Elphick, Lucy M, Anderson, Alexandra A, Child, Emma S, Mann, David J, Gouverneur, Véronique

“…Enantioenriched tetrafluorinated aryl-C-nucleosides were synthesised in four steps from 1-benzyloxy-4-bromo-3,3,4,4-tetrafluorobutan-2-ol. The presence of the…”
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Intramolecular OHFC Hydrogen Bonding in Fluorinated Carbohydrates: CHF is a Better Hydrogen Bond Acceptor than CF2 by Giuffredi, Guy T, Gouverneur, Véronique, Bernet, Bruno

“…An intramolecular bifurcated H-bond from the axial HO-2 group to the axial F-4 atom and to the O5 atom of α-D-hexopyranosides in apolar solvents is evidenced…”
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Intramolecular OH⋅⋅⋅FC Hydrogen Bonding in Fluorinated Carbohydrates: CHF is a Better Hydrogen Bond Acceptor than CF 2 by Giuffredi, Guy T., Gouverneur, Véronique, Bernet, Bruno

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Intramolecular OHFC Hydrogen Bonding in Fluorinated Carbohydrates: CHF is a Better Hydrogen Bond Acceptor than CF sub(2) by Giuffredi, Guy T, Gouverneur, Veronique, Bernet, Bruno

“…An intramolecular bifurcated H-bond from the axial HO-2 group to the axial F-4 atom and to the O5 atom of [alpha]-D-hexopyranosides in apolar solvents is…”
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Front Cover: Identifying Lysophosphatidic Acid Acyltransferase β (LPAAT‐β) as the Target of a Nanomolar Angiogenesis Inhibitor from a Phenotypic Screen Using the Polypharmacology Browser PPB2 (ChemMedChem 2/2019) by Poirier, Marion, Awale, Mahendra, Roelli, Matthias A., Giuffredi, Guy T., Ruddigkeit, Lars, Evensen, Lasse, Stooss, Amandine, Calarco, Serafina, Lorens, James B., Charles, Roch‐Philippe, Reymond, Jean‐Louis

“…The Front Cover illustrates the chemical space distance relationship between an angiogenesis inhibitory triazine identified in a phenotypic screen (structure…”
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De Novo Synthesis of Racemic 4-Deoxy-4,4-difluoro- and 2,4-Dideoxy-2,4,4-trifluorohexosides: Women in Chemistry by GIUFFREDI, Guy T, BERNET, Bruno, GOUVERNEUR, Veronique

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Asymmetric de novo synthesis of fluorinated d-glucitol and d-mannitol analogues by Giuffredi, Guy T., Purser, Sophie, Sawicki, Marcin, Thompson, Amber L., Gouverneur, Véronique

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Coordination diversity in hydrogen-bonded homoleptic fluoride-alcohol complexes modulates reactivityElectronic supplementary information (ESI) available: Detailed procedures for the synthesis of fluoride-alcohol complexes, 1H and 13C NMR spectra, crystal structures and reaction kinetics. CCDC 1401765-1401778. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5sc01812a by Engle, Keary M, Pfeifer, Lukas, Pidgeon, George W, Giuffredi, Guy T, Thompson, Amber L, Paton, Robert S, Brown, John M, Gouverneur, Véronique

“…The nucleophilic reactivity of fluoride ion is altered in the presence of hydrogen-bond donors, including alcohols. Relatively little is known about the…”
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Coordination diversity in hydrogen-bonded homoleptic fluoride–alcohol complexes modulates reactivity† †Electronic supplementary information (ESI) available: Detailed procedures for the synthesis of fluoride–alcohol complexes, 1H and 13C NMR spectra, crystal structures and reaction kinetics. CCDC 1401765–1401778. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5sc01812a Click here for additional data file. Click here for additional data file by Engle, Keary M., Pfeifer, Lukas, Pidgeon, George W., Giuffredi, Guy T., Thompson, Amber L., Paton, Robert S., Brown, John M., Gouverneur, Véronique

“…The X-ray structures of fourteen novel fluoride–alcohol complexes with tetrabutylammonium as the counterion show coordination diversity varying from four to…”
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