Search Results - "Giudice, Anna M"

CAR T-cell-mediated delivery of bispecific innate immune cell engagers for neuroblastoma by Pascual-Pasto, Guillem, McIntyre, Brendan, Hines, Margaret G., Giudice, Anna M., Garcia-Gerique, Laura, Hoffmann, Jennifer, Mishra, Pamela, Matlaga, Stephanie, Lombardi, Simona, Shraim, Rawan, Schürch, Patrick M., Yarmarkovich, Mark, Hofmann, Ted J., Alikarami, Fatemeh, Martinez, Daniel, Tsang, Matthew, Gil-de-Gómez, Luis, Spear, Timothy T., Bernt, Kathrin M., Wolpaw, Adam J., Dimitrov, Dimiter S., Li, Wei, Bosse, Kristopher R.

“…Novel chimeric antigen receptor (CAR) T-cell approaches are needed to improve therapeutic efficacy in solid tumors. High-risk neuroblastoma is an aggressive…”
Get full text

GPC2 antibody–drug conjugate reprograms the neuroblastoma immune milieu to enhance macrophage-driven therapies by Pascual-Pasto, Guillem, McIntyre, Brendan, Shraim, Rawan, Buongervino, Samantha N, Erbe, Amy K, Zhelev, Doncho V, Sadirova, Shakhnozakhon, Giudice, Anna M, Martinez, Daniel, Garcia-Gerique, Laura, Dimitrov, Dimiter S, Sondel, Paul M, Bosse, Kristopher R

“…BackgroundAntibody–drug conjugates (ADCs) that deliver cytotoxic drugs to tumor cells have emerged as an effective and safe anticancer therapy. ADCs may induce…”
Get full text

Targeting GPC2 on Intraocular and CNS Metastatic Retinoblastomas with Local and Systemic Delivery of CAR T Cells by Pascual-Pasto, Guillem, McIntyre, Brendan, Giudice, Anna M, Alikarami, Fatemeh, Morrissey, Amanda, Matlaga, Stephanie, Hofmann, Ted J, Burgueño, Victor, Harvey, Kyra, Martinez, Daniel, Shah, Amish C, Foster, Jessica B, Pogoriler, Jennifer, Eagle, Ralph C, Carcaboso, Angel M, Shields, Carol L, Leahey, Ann-Marie, Bosse, Kristopher R

“…Retinoblastoma is the most common intraocular malignancy in children. Although new chemotherapeutic approaches have improved ocular salvage rates, novel…”
Get full text

Abstract 5121: Next-generation immunocompetent and humanized neuroblastoma murine models for the discovery and validation of novel immunotherapies by Spear, Timothy T., Posthill, Elisabeth, Groff, David, Giudice, Anna M., Bosse, Kristopher R., Ma, Leyuan, Schoenberger, Stephen P., Maris, John M.

“…The success of CD19-directed chimeric antigen receptor (CAR)-T cell therapy for ALL has yet to be matched in solid pediatric malignancies. Moreover, immune…”
Get full text

Abstract 5118: Neuroblastoma extracellular vesicles present GPC2 and activate GPC2 CAR T cells in an antigen-dependent manner by Giudice, Anna M., Matlaga, Stephanie, Pascual-Pasto, Guillem, Schuerch, Patrick M., Rouin, Geoffrey, McIntyre, Brendan, Zecchino, Vincent P., Bosse, Kristopher R.

“…Glypican 2 (GPC2) chimeric antigen receptor (CAR) T cells are safe and efficacious in neuroblastoma and are currently being tested in a first-in-human Phase 1…”
Get full text