Search Results - "Gittos, Maurice W"

Toward a better understanding of depression and anxiety. The importance of tryptophan hydroxylase activation blockade: The origin of a unique anxiolytic antidepressant by Gittos, Maurice W.

“…The serotonin (5‐HT) deficiency theory of depression has misled medical science. Inhibitors of 5‐HT reuptake were the basis of the hypothesis and display…”
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Toward a better understanding of depression and anxiety: the involvement of stress and tryptophan hydroxylase activation by Gittos, Maurice W.

“…Tryptophan hydroxylase (TPH) has been implicated as the key enzyme involved in the etiology of the affective disorders, anxiety and depression. In addition to…”
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Antidepressant-like action of AGN 2979, a tryptophan hydroxylase activation inhibitor, in a chronic mild stress model of depression in rats by Gittos, Maurice W, Papp, Mariusz

“…Chronic mild stress (CMS) procedure was used to study an antidepressant-like activity of AGN 2979, a selective inhibitor of tryptophan hydroxylase (TH)…”
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Toward a better understanding of depression: New mechanistic considerations of antidepressant action provide a basis for development of delay-free drugs by Gittos, Maurice W.

“…Presently accepted theories of the etiology of depression stem from the pharmacological evaluation of compounds serendipitously found to alleviate the…”
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Electrophysiological, biochemical and behavioral evidence for 5-HT2 and 5-HT3 mediated control of dopaminergic function by Palfreyman, M G, Schmidt, C J, Sorensen, S M, Dudley, M W, Kehne, J H, Moser, P, Gittos, M W, Carr, A A

“…Several lines of evidence have suggested a link between serotonergic and dopaminergic systems in the brain. The interpretation of much of these early data…”
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Graphics computer-aided receptor mapping as a predictive tool for drug design: development of potent, selective, and stereospecific ligands for the 5-HT1A receptor by Hibert, Marcel F, Gittos, Maurice W, Middlemiss, Derek N, Mir, Anis K, Fozard, John R

“…A conformational study of four 5-HT1A (serotonin) receptor ligands ((R-(-)-methiothepin, spiperone, (S)-(-)-propranolol, and buspirone) led to the definition…”
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