Search Results - "Gittelman, Rachel"

Excavating Neandertal and Denisovan DNA from the genomes of Melanesian individuals by Vernot, Benjamin, Tucci, Serena, Kelso, Janet, Schraiber, Joshua G., Wolf, Aaron B., Gittelman, Rachel M., Dannemann, Michael, Grote, Steffi, McCoy, Rajiv C., Norton, Heather, Scheinfeldt, Laura B., Merriwether, David A., Koki, George, Friedlaender, Jonathan S., Wakefield, Jon, Pääbo, Svante, Akey, Joshua M.

“…Although Neandertal sequences that persist in the genomes of modern humans have been identified in Eurasians, comparable studies in people whose ancestors…”
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Archaic Hominin Admixture Facilitated Adaptation to Out-of-Africa Environments by Gittelman, Rachel M., Schraiber, Joshua G., Vernot, Benjamin, Mikacenic, Carmen, Wurfel, Mark M., Akey, Joshua M.

“…As modern humans dispersed from Africa throughout the world, they encountered and interbred with archaic hominins, including Neanderthals and Denisovans [1,…”
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Neoadjuvant versus adjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma by Blank, Christian U., Rozeman, Elisa A., Fanchi, Lorenzo F., Sikorska, Karolina, van de Wiel, Bart, Kvistborg, Pia, Krijgsman, Oscar, van den Braber, Marlous, Philips, Daisy, Broeks, Annegien, van Thienen, Johannes V., Mallo, Henk A., Adriaansz, Sandra, ter Meulen, Sylvia, Pronk, Loes M., Grijpink-Ongering, Lindsay G., Bruining, Annemarie, Gittelman, Rachel M., Warren, Sarah, van Tinteren, Harm, Peeper, Daniel S., Haanen, John B. A. G., van Akkooi, Alexander C. J., Schumacher, Ton N.

“…Adjuvant ipilimumab (anti-CTLA-4) and nivolumab (anti-PD-1) both improve relapse-free survival of stage III melanoma patients 1 , 2 . In stage IV disease, the…”
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Impact of HLA type, age and chronic viral infection on peripheral T-cell receptor sharing between unrelated individuals by Johnson, Sarah A, Seale, Spencer L, Gittelman, Rachel M, Rytlewski, Julie A, Robins, Harlan S, Fields, Paul A

“…The human adaptive immune system must generate extraordinary diversity to be able to respond to all possible pathogens. The T-cell repertoire derives this high…”
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Characteristics of Neutral and Deleterious Protein-Coding Variation among Individuals and Populations by Fu, Wenqing, Gittelman, Rachel M., Bamshad, Michael J., Akey, Joshua M.

“…Whole-genome and exome data sets continue to be produced at a frenetic pace, resulting in massively large catalogs of human genomic variation. However, a clear…”
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Comprehensive identification and analysis of human accelerated regulatory DNA by Gittelman, Rachel M, Hun, Enna, Ay, Ferhat, Madeoy, Jennifer, Pennacchio, Len, Noble, William S, Hawkins, R David, Akey, Joshua M

“…It has long been hypothesized that changes in gene regulation have played an important role in human evolution, but regulatory DNA has been much more difficult…”
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A randomised, single-blind, placebo-controlled, dose-finding safety and tolerability study of the anti-CD3 monoclonal antibody otelixizumab in new-onset type 1 diabetes by Keymeulen, Bart, van Maurik, André, Inman, Dave, Oliveira, João, McLaughlin, Rene, Gittelman, Rachel M., Roep, Bart O., Gillard, Pieter, Hilbrands, Robert, Gorus, Frans, Mathieu, Chantal, Van de Velde, Ursule, Wisniacki, Nicolas, Napolitano, Antonella

“…Aims/hypothesis Numerous clinical studies have investigated the anti-CD3ɛ monoclonal antibody otelixizumab in individuals with type 1 diabetes, but limited…”
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Concurrent PD-1 Blockade Negates the Effects of OX40 Agonist Antibody in Combination Immunotherapy through Inducing T-cell Apoptosis by Shrimali, Rajeev K, Ahmad, Shamim, Verma, Vivek, Zeng, Peng, Ananth, Sudha, Gaur, Pankaj, Gittelman, Rachel M, Yusko, Erik, Sanders, Catherine, Robins, Harlan, Hammond, Scott A, Janik, John E, Mkrtichyan, Mikayel, Gupta, Seema, Khleif, Samir N

“…Combination therapies that depend on checkpoint inhibitor antibodies (Abs) such as for PD-1 or its ligand (PD-L1) together with immune stimulatory agonist Abs…”
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Clinical Validation of a Novel T-Cell Receptor Sequencing Assay for Identification of Recent or Prior Severe Acute Respiratory Syndrome Coronavirus 2 Infection by Dalai, Sudeb C, Dines, Jennifer N, Snyder, Thomas M, Gittelman, Rachel M, Eerkes, Tera, Vaney, Pashmi, Howard, Sally, Akers, Kipp, Skewis, Lynell, Monteforte, Anthony, Witte, Pamela R, Wolf, Cristina, Nesse, Hans, Herndon, Megan, Qadeer, Jia, Duffy, Sarah, Svejnoha, Emily, Taromino, Caroline, Kaplan, Ian M, Alsobrook, John, Manley, Thomas, Baldo, Lance

“…Abstract Background While diagnostic, therapeutic, and vaccine development in the coronavirus disease 2019 (COVID-19) pandemic has proceeded at unprecedented…”
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An Allogeneic Multiple Myeloma GM-CSF-Secreting Vaccine with Lenalidomide Induces Long-term Immunity and Durable Clinical Responses in Patients in Near Complete Remission by Biavati, Luca, Huff, Carol Ann, Ferguson, Anna, Sidorski, Amy, Stevens, M Amanda, Rudraraju, Lakshmi, Zucchinetti, Cristina, Ali, Syed Abbas, Imus, Philip, Gocke, Christian B, Gittelman, Rachel M, Johnson, Sarah, Sanders, Catherine, Vignali, Marissa, Gandhi, Anita, Ye, Xiaobu, Noonan, Kimberly A, Borrello, Ivan

“…This proof-of-principle clinical trial evaluated whether an allogeneic multiple myeloma GM-CSF-secreting vaccine (MM-GVAX) in combination with lenalidomide…”
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The T-Cell Response to SARS-CoV-2 Vaccination in Inflammatory Bowel Disease is Augmented with Anti-TNF Therapy by Li, Dalin, Xu, Alexander, Mengesha, Emebet, Elyanow, Rebecca, Gittelman, Rachel M, Chapman, Heidi, Prostko, John C, Frias, Edwin C, Stewart, James L, Pozdnyakova, Valeriya, Debbas, Philip, Mujukian, Angela, Horizon, Arash A, Merin, Noah, Joung, Sandy, Botwin, Gregory J, Sobhani, Kimia, Figueiredo, Jane C, Cheng, Susan, Kaplan, Ian M, McGovern, Dermot P B, Merchant, Akil, Melmed, Gil Y, Braun, Jonathan

“…Lay Summary T-cell and antibody responses to severe acute respiratory syndrome coronavirus 2 vaccination in inflammatory bowel disease patients are poorly…”
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Repeated mRNA vaccination sequentially boosts SARS-CoV-2-specific CD8+ T cells in persons with previous COVID-19 by Ford, Emily S., Mayer-Blackwell, Koshlan, Jing, Lichen, Laing, Kerry J., Sholukh, Anton M., St. Germain, Russell, Bossard, Emily L., Xie, Hong, Pulliam, Thomas H., Jani, Saumya, Selke, Stacy, Burrow, Carlissa J., McClurkan, Christopher L., Wald, Anna, Greninger, Alexander L., Holbrook, Michael R., Eaton, Brett, Eudy, Elizabeth, Murphy, Michael, Postnikova, Elena, Robins, Harlan S., Elyanow, Rebecca, Gittelman, Rachel M., Ecsedi, Matyas, Wilcox, Elise, Chapuis, Aude G., Fiore-Gartland, Andrew, Koelle, David M.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hybrid immunity is more protective than vaccination or previous infection alone. To investigate…”
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Evolution of DNAase I Hypersensitive Sites in MHC Regulatory Regions of Primates by Jin, Yabin, Gittelman, Rachel M, Lu, Yueer, Liu, Xiaohui, Li, Ming D, Ling, Fei, Akey, Joshua M

“…It has been challenging to determine the disease-causing variant(s) for most major histocompatibility complex (MHC)-associated diseases. However, it is…”
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Detecting Sources of Transcriptional Heterogeneity in Large-Scale RNA-Seq Data Sets by Searle, Brian C, Gittelman, Rachel M, Manor, Ohad, Akey, Joshua M

“…Gene expression levels are dynamic molecular phenotypes that respond to biological, environmental, and technical perturbations. Here we use a novel…”
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Differences in SARS-CoV-2 Vaccine Response Dynamics Between Class-I- and Class-II-Specific T-Cell Receptors in Inflammatory Bowel Disease by Xu, Alexander M, Li, Dalin, Ebinger, Joseph E, Mengesha, Emebet, Elyanow, Rebecca, Gittelman, Rachel M, Chapman, Heidi, Joung, Sandy, Botwin, Gregory J, Pozdnyakova, Valeriya, Debbas, Philip, Mujukian, Angela, Prostko, John C, Frias, Edwin C, Stewart, James L, Horizon, Arash A, Merin, Noah, Sobhani, Kimia, Figueiredo, Jane C, Cheng, Susan, Kaplan, Ian M, McGovern, Dermot P B, Merchant, Akil, Melmed, Gil Y, Braun, Jonathan

“…T-cells specifically bind antigens to induce adaptive immune responses using highly specific molecular recognition, and a diverse T-cell repertoire with…”
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T cell receptor sequencing identifies prior SARS-CoV-2 infection and correlates with neutralizing antibodies and disease severity by Elyanow, Rebecca, Snyder, Thomas M, Dalai, Sudeb C, Gittelman, Rachel M, Boonyaratanakornkit, Jim, Wald, Anna, Selke, Stacy, Wener, Mark H, Morishima, Chihiro, Greninger, Alexander L, Gale, Jr, Michael, Hsiang, Tien-Ying, Jing, Lichen, Holbrook, Michael R, Kaplan, Ian M, Zahid, H Jabran, May, Damon H, Carlson, Jonathan M, Baldo, Lance, Manley, Thomas, Robins, Harlan S, Koelle, David M

“…BACKGROUNDMeasuring the immune response to SARS-CoV-2 enables assessment of past infection and protective immunity. SARS-CoV-2 infection induces humoral and T…”
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CD4+ T cell and M2 macrophage infiltration predict dedifferentiated liposarcoma patient outcomes by Schroeder, Brett A, LaFranzo, Natalie A, LaFleur, Bonnie J, Gittelman, Rachel M, Vignali, Marissa, Zhang, Shihong, Flanagan, Kevin C, Rytlewski, Julie, Riolobos, Laura, Schulte, Brian C, Kim, Teresa S, Chen, Eleanor, Smythe, Kimberly S, Wagner, Michael J, Mantilla, Jose G, Campbell, Jean S, Pierce, Robert H, Jones, Robin L, Cranmer, Lee D, Pollack, Seth M

“…BackgroundDedifferentiated liposarcoma (DDLPS) is one of the most common soft tissue sarcoma subtypes and is devastating in the advanced/metastatic stage…”
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Comprehensive T cell repertoire characterization of non-small cell lung cancer by Reuben, Alexandre, Zhang, Jiexin, Chiou, Shin-Heng, Gittelman, Rachel M., Li, Jun, Lee, Won-Chul, Fujimoto, Junya, Behrens, Carmen, Liu, Xiaoke, Wang, Feng, Quek, Kelly, Wang, Chunlin, Kheradmand, Farrah, Chen, Runzhe, Chow, Chi-Wan, Lin, Heather, Bernatchez, Chantale, Jalali, Ali, Hu, Xin, Wu, Chang-Jiun, Eterovic, Agda Karina, Parra, Edwin Roger, Yusko, Erik, Emerson, Ryan, Benzeno, Sharon, Vignali, Marissa, Wu, Xifeng, Ye, Yuanqing, Little, Latasha D., Gumbs, Curtis, Mao, Xizeng, Song, Xingzhi, Tippen, Samantha, Thornton, Rebecca L., Cascone, Tina, Snyder, Alexandra, Wargo, Jennifer A., Herbst, Roy, Swisher, Stephen, Kadara, Humam, Moran, Cesar, Kalhor, Neda, Zhang, Jianhua, Scheet, Paul, Vaporciyan, Ara A., Sepesi, Boris, Gibbons, Don L., Robins, Harlan, Hwu, Patrick, Heymach, John V., Sharma, Padmanee, Allison, James P., Baladandayuthapani, Veera, Lee, Jack J., Davis, Mark M., Wistuba, Ignacio I., Futreal, P. Andrew, Zhang, Jianjun

“…Immunotherapy targeting T cells is increasingly utilized to treat solid tumors including non-small cell lung cancer (NSCLC). This requires a better…”
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Longitudinal analysis of T cell receptor repertoires reveals shared patterns of antigen-specific response to SARS-CoV-2 infection by Gittelman, Rachel M, Lavezzo, Enrico, Snyder, Thomas M, Zahid, H Jabran, Carty, Cara L, Elyanow, Rebecca, Dalai, Sudeb, Kirsch, Ilan, Baldo, Lance, Manuto, Laura, Franchin, Elisa, Del Vecchio, Claudia, Pacenti, Monia, Boldrin, Caterina, Cattai, Margherita, Saluzzo, Francesca, Padoan, Andrea, Plebani, Mario, Simeoni, Fabio, Bordini, Jessica, Lorè, Nicola I, Lazarević, Dejan, Cirillo, Daniela M, Ghia, Paolo, Toppo, Stefano, Carlson, Jonathan M, Robins, Harlan S, Crisanti, Andrea, Tonon, Giovanni

“…T cells play a prominent role in orchestrating the immune response to viral diseases, but their role in the clinical presentation and subsequent immunity to…”
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Exploring signatures of positive selection in pigmentation candidate genes in populations of East Asian ancestry by Hider, Jessica L, Gittelman, Rachel M, Shah, Tapan, Edwards, Melissa, Rosenbloom, Arnold, Akey, Joshua M, Parra, Esteban J

“…Currently, there is very limited knowledge about the genes involved in normal pigmentation variation in East Asian populations. We carried out a genome-wide…”
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