Search Results - "Gitego, Nadege"

Inhibitors of BRAF dimers using an allosteric site by Cotto-Rios, Xiomaris M., Agianian, Bogos, Gitego, Nadege, Zacharioudakis, Emmanouil, Giricz, Orsi, Wu, Yang, Zou, Yiyu, Verma, Amit, Poulikakos, Poulikos I., Gavathiotis, Evripidis

“…BRAF kinase, a critical effector of the ERK signaling pathway, is hyperactivated in many cancers. Oncogenic BRAF V600E signals as an active monomer in the…”
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Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer by Lopez, Andrea, Reyna, Denis E., Gitego, Nadege, Kopp, Felix, Zhou, Hua, Miranda-Roman, Miguel A., Nordstrøm, Lars Ulrik, Narayanagari, Swathi-Rao, Chi, Ping, Vilar, Eduardo, Tsirigos, Aristotelis, Gavathiotis, Evripidis

“…Deregulation of the BCL-2 family interaction network ensures cancer resistance to apoptosis and is a major challenge to current treatments. Cancer cells…”
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Chemical modulation of cytosolic BAX homodimer potentiates BAX activation and apoptosis by Gitego, Nadege, Agianian, Bogos, Mak, Oi Wei, Kumar MV, Vasantha, Cheng, Emily H., Gavathiotis, Evripidis

“…The BCL-2 family protein BAX is a major regulator of physiological and pathological cell death. BAX predominantly resides in the cytosol in a quiescent state…”
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North American ATLL has a distinct mutational and transcriptional profile and responds to epigenetic therapies by Shah, Urvi A., Chung, Elaine Y., Giricz, Orsi, Pradhan, Kith, Kataoka, Keisuke, Gordon-Mitchell, Shanisha, Bhagat, Tushar D., Mai, Yun, Wei, Yongqiang, Ishida, Elise, Choudhary, Gaurav S., Joseph, Ancy, Rice, Ronald, Gitego, Nadege, Parrish, Crystall, Bartenstein, Matthias, Goel, Swati, Mantzaris, Ioannis, Shastri, Aditi, Derman, Olga, Binder, Adam, Gritsman, Kira, Kornblum, Noah, Braunschweig, Ira, Bhagat, Chirag, Hall, Jeff, Graber, Armin, Ratner, Lee, Wang, Yanhua, Ogawa, Seishi, Verma, Amit, Ye, B. Hilda, Janakiram, Murali

“…Adult T-cell leukemia lymphoma (ATLL) is a rare T cell neoplasm that is endemic in Japanese, Caribbean, and Latin American populations. Most North American…”
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ASXL1 mutations are associated with distinct epigenomic alterations that lead to sensitivity to venetoclax and azacytidine by Rahmani, Nora E., Ramachandra, Nandini, Sahu, Srabani, Gitego, Nadege, Lopez, Andrea, Pradhan, Kith, Bhagat, Tushar D., Gordon-Mitchell, Shanisha, Pena, Bianca Rivera, Kazemi, Mohammad, Rao, Keshav, Giricz, Orsi, Maqbool, Shahina Bano, Olea, Raul, Zhao, Yongmei, Zhang, Jinghang, Dolatshad, Hamid, Tittrea, Vickram, Tatwavedi, Dharamveer, Singh, Shalini, Lee, Juseong, Sun, Tianyu, Steidl, Ulrich, Shastri, Aditi, Inoue, Daichi, Abdel-Wahab, Omar, Pellagatti, Andrea, Gavathiotis, Evripidis, Boultwood, Jacqueline, Verma, Amit

“…The BCL2-inhibitor, Venetoclax (VEN), has shown significant anti-leukemic efficacy in combination with the DNMT-inhibitor, Azacytidine (AZA). To explore the…”
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Modulation of Cytosolic Autoinhibited BAX Dimer as a Novel Strategy to Potentiate Apoptosis in Cancer by Gitego, Nadege

“…Apoptosis is an evolutionary conserved form of regulated cell death essential for normal development and tissue homeostasis. Dysregulation of apoptosis…”
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Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin by Gui, Dan Y., Sullivan, Lucas B., Luengo, Alba, Hosios, Aaron M., Bush, Lauren N., Gitego, Nadege, Davidson, Shawn M., Freinkman, Elizaveta, Thomas, Craig J., Vander Heiden, Matthew G.

“…Metformin use is associated with reduced cancer mortality, but how metformin impacts cancer outcomes is controversial. Although metformin can act on cells…”
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Abstract LB-B10: Targeting a new allosteric site modulates selectivity of BRAF dimer inhibition by Agianian, Paul (Bogos), Cotto-Rios, Xiomaris M, Gitego, Nadege, Zachariouadakis, Emmanouil, Gavathiotis, Evripidis

“…Abstract BRAF mutants are present in ~50% of melanoma patients as well as in colorectal (~10%), thyroid carcinomas (~40%) and other malignancies. FDA-approved…”
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A STAT3 Degrader Demonstrates Pre-Clinical Efficacy in Venetoclax Resistant Acute Myeloid Leukemia by Chakraborty, Samarpana, Morganti, Claudia, Dey, Joyoti, Zhang, Hui, Aluri, Srinivas, Gitego, Nadege, Pradhan, Kith, Rivera, Bianca, Chutake, Yogesh, Skwarska, Anna, Mantzaris, Ioannis, Goldfinger, Mendel, Feldman, Eric J, Choudhary, Gaurav S, Hubner, Stefan, Qiu, Yihua, Brown, Brandon D., Verma, Amit, Gavathiotis, Evripidis, Konopleva, Marina Y., Kornblau, Steven M., Gollob, Jared, Ito, Keisuke, Shastri, Aditi

“…Introduction: Acute Myeloid leukemia (AML) is an aggressive hematological malignancy resulting from the transformation of immature myeloid progenitor cells…”
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Abstract 1993: Cytosolic BAX dimerization as a mechanism of resistance to apoptosis and a novel target to potentiate BAX activation and apoptosis by Gitego, Nadege, Agianian, Bogos, Mak, Oi Wei, MV, Vasantha Kumar, Cheng, Emily, Gavathiotis, Evripidis

“…Abstract BCL-2 family proteins are master regulators of cellular life and death and have become drug targets for the development of therapeutic agents to…”
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Inhibitors of BRAF dimers using an allosteric site by Cotto-Rios, Xiomaris M., Agianian, Bogos, Gitego, Nadege, Zacharioudakis, Emmanouil, Giricz, Orsi, Wu, Yang, Zou, Yiyu, Verma, Amit, Poulikakos, Poulikos I., Gavathiotis, Evripidis

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North American Adult T Cell Leukemia Lymphoma (ATLL) Is Characterized By Distinct, Therapeutically Targetable Mutations in Epigenetic Modifiers by Shah, Urvi A, Wang, Yanhua, Giricz, Orsolya, Gordon, Shanisha, Bhagat, Tushar Damodar, Mai, Yun, Wei, Yongqiang, Gitego, Nadege, Choudhary, Gaurav, Pradhan, Kith, Bartenstein, Matthias, Rice, Ronald, Goel, Swati, Mantzaris, Ioannis, Shastri, Aditi, Derman, Olga, Binder, Adam F., Gritsman, Kira, Kornblum, Noah, Braunschweig, Ira, Verma, Amit, Ye, B. Hilda, Janakiram, Murali

“…Introduction: We described the mutational spectrum of ATLL in North American patients at ASH 2016 and found that these patients have a heterogenous mutational…”
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