Search Results - "Gispert, Juan D"

Higher prevalence of cerebral white matter hyperintensities in homozygous APOE-ɛ4 allele carriers aged 45–75: Results from the ALFA study by Rojas, Santiago, Brugulat-Serrat, Anna, Bargalló, Nuria, Minguillón, Carolina, Tucholka, Alan, Falcon, Carles, Carvalho, Andreia, Morán, Sebastian, Esteller, Manel, Gramunt, Nina, Fauria, Karine, Camí, Jordi, Molinuevo, José L, Gispert, Juan D

“…Cerebral white matter hyperintensities are believed the consequence of small vessel disease and are associated with risk and progression of Alzheimer's…”
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A Personalized Preclinical Model to Evaluate the Metastatic Potential of Patient-Derived Colon Cancer Initiating Cells by PUIG, Isabel, CHICOTE, Irene, MENDIZABAL, Leire, MORENO, Debora, CHARCO, Ramón, ESPIN, Eloy, PRAT, Aleix, ELEZ, Maria Elena, ARGILES, Guillem, VIVANCOS, Ana, TABERNERO, Josep, ROJAS, Santiago, TENBAUM, Stephan P, PALMER, Hector G, ARQUES, Oriol, HERANCE, José Raúl, GISPERT, Juan D, JIMENEZ, José, LANDOLFI, Stefania, CACI, Karina, ALLENDE, Helena

“…Within the aim of advancing precision oncology, we have generated a collection of patient-derived xenografts (PDX) characterized at the molecular level, and a…”
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Mechanisms of functional compensation, delineated by eigenvector centrality mapping, across the pathophysiological continuum of Alzheimer's disease by Skouras, Stavros, Falcon, Carles, Tucholka, Alan, Rami, Lorena, Sanchez-Valle, Raquel, Lladó, Albert, Gispert, Juan D, Molinuevo, José Luís

“…Mechanisms of functional compensation throughout the progression of Alzheimer's disease (AD) remain largely underspecified. By investigating functional…”
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Brain transcriptomic profiling reveals common alterations across neurodegenerative and psychiatric disorders by Sadeghi, Iman, Gispert, Juan D., Palumbo, Emilio, Muñoz-Aguirre, Manuel, Wucher, Valentin, D'Argenio, Valeria, Santpere, Gabriel, Navarro, Arcadi, Guigo, Roderic, Vilor-Tejedor, Natàlia

“…[Display omitted] Neurodegenerative and neuropsychiatric disorders (ND-NPs) are multifactorial, polygenic and complex behavioral phenotypes caused by brain…”
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The expression of GLP‐1 receptor mRNA and protein allows the effect of GLP‐1 on glucose metabolism in the human hypothalamus and brainstem by Alvarez, Elvira, Martínez, M. Dolores, Roncero, Isabel, Chowen, Julie A., García‐Cuartero, Beatriz, Gispert, Juan D., Sanz, Carmen, Vázquez, Patricia, Maldonado, Antonio, De Cáceres, Javier, Desco, Manuel, Pozo, Miguel Angel, Blázquez, Enrique

“…In the present work, several experimental approaches were used to determine the presence of the glucagon‐like peptide‐1 receptor (GLP‐1R) and the biological…”
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Single-cell Transcriptional Changes in Neurodegenerative Diseases by Ahmadi, Amirhossein, Gispert, Juan D., Navarro, Arcadi, Vilor-Tejedor, Natalia, Sadeghi, Iman

“…•Sex-specific changes observed in AD pathology in neurons and microglia.•Dopaminergic neurons revealed marker genes associated with PD.•Astrocytic genes…”
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In vivo molecular imaging of the GABA/benzodiazepine receptor complex in the aged rat brain by Hoekzema, Elseline, Rojas, Santiago, Herance, Raúl, Pareto, Deborah, Abad, Sergio, Jiménez, Xavier, Figueiras, Francisca P, Popota, Foteini, Ruiz, Alba, Flotats, Núria, Fernández, Francisco J, Rocha, Milagros, Rovira, Mariana, Víctor, Víctor M, Gispert, Juan D

“…Abstract The GABA-ergic system, known to regulate neural tissue genesis during cortical development, has been postulated to play a role in cerebral aging…”
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Cerebral metabolic changes induced by clozapine in schizophrenia and related to clinical improvement by MOLINA, Vicente, GISPERT, Juan D, REIG, Santiago, SANZ, Javier, PASCAU, Javier, SANTOS, Andrés, DESCO, Manuel, PALOMO, Tomas

“…The study of the different effects on brain metabolism between typical and atypical antipsychotics would aid in understanding their mechanisms of action…”
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Modeling practice effects in healthy middle-aged participants of the Alzheimer and Families parent cohort by Sánchez-Benavides, Gonzalo, Gispert, Juan D, Fauria, Karine, Molinuevo, José Luis, Gramunt, Nina

“…Abstract Introduction Repetitive administration of neuropsychological tests can lead to performance improvement merely due to previous exposure. The magnitude…”
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Simulating the effect of cerebral blood flow changes on regional quantification of [18F]flutemetamol and [18F]florbetaben studies by Heeman, Fiona, Yaqub, Maqsood, Lopes Alves, Isadora, Heurling, Kerstin, Bullich, Santiago, Gispert, Juan D, Boellaard, Ronald, Lammertsma, Adriaan A

“…Global and regional changes in cerebral blood flow (CBF) can result in biased quantitative estimates of amyloid load by PET imaging. Therefore, the current…”
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β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer by Tenbaum, Stephan P, Ordóñez-Morán, Paloma, Puig, Isabel, Chicote, Irene, Arqués, Oriol, Landolfi, Stefania, Fernández, Yolanda, Herance, José Raúl, Gispert, Juan D, Mendizabal, Leire, Aguilar, Susana, Cajal, Santiago Ramón y, Schwartz, Simó, Vivancos, Ana, Espín, Eloy, Rojas, Santiago, Baselga, José, Tabernero, Josep, Muñoz, Alberto, Palmer, Héctor G

“…The crosstalk between the transcriptional activity of β-catenin and FOXO3a reveals unexpected pro-metastatic cooperative effects of these pathways through…”
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A 18F-fluorodeoxyglucose MicroPET Imaging Study to Assess Changes in Brain Glucose Metabolism in a Rat Model of Surgery-induced Latent Pain Sensitization by ROMERO, Asunción, ROJAS, Santiago, CABANERO, David, GISPERT, Juan D, HERANCE, Jose R, CAMPILLO, Ana, PUIG, Margarita M

“…Neuroplastic changes involved in latent pain sensitization after surgery are poorly defined. We assessed temporal changes in glucose brain metabolism in a…”
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N-acetyl-aspartate levels in the dorsolateral prefrontal cortex in the early years of schizophrenia are inversely related to disease duration by Molina, Vicente, Sánchez, Javier, Reig, Santiago, Sanz, Javier, Benito, Carlos, Santamarta, Cristina, Pascau, Javier, Sarramea, Fernando, Gispert, Juan D., Misiego, José M., Palomo, Tomás, Desco, Manuel

“…Magnetic resonance spectroscopy studies in schizophrenia have revealed consistently reduced N-acetyl aspartate (NAA) levels in chronic patients, but not in…”
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Method for bias field correction of brain T1-weighted magnetic resonance images minimizing segmentation error by Gispert, Juan D., Reig, Santiago, Pascau, Javier, Vaquero, Juan J., García-Barreno, Pedro, Desco, Manuel

“…This work presents a new algorithm (nonuniform intensity correction; NIC) for correction of intensity inhomogeneities in T1‐weighted magnetic resonance (MR)…”
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The Crus exhibits stronger functional connectivity with executive network nodes than with the default mode network by Skouras, Stavros, Gispert, Juan D, Molinuevo, José Luís

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Multipurpose Virtual Reality Environment for Biomedical and Health Applications by Torner, Jordi, Skouras, Stavros, Molinuevo, Jose L., Gispert, Juan D., Alpiste, Francisco

“…Virtual reality is a trending, widely accessible, and contemporary technology of increasing utility to biomedical and health applications. However, most…”
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Biodistribution of Amino-Functionalized Diamond Nanoparticles. In Vivo Studies Based on 18F Radionuclide Emission by Rojas, Santiago, Gispert, Juan D, Martín, Roberto, Abad, Sergio, Menchón, Cristina, Pareto, Deborah, Víctor, Víctor M, Álvaro, Mercedes, García, Hermenegildo, Herance, J. Raúl

“…Nanoparticles have been proposed for several biomedical applications; however, in vivo biodistribution studies to confirm their potential are scarce…”
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Earliest amyloid and tau deposition modulate the influence of limbic networks during closed-loop hippocampal downregulation by Skouras, Stavros, Torner, Jordi, Andersson, Patrik, Koush, Yury, Falcon, Carles, Minguillon, Carolina, Fauria, Karine, Alpiste, Francesc, Blenow, Kaj, Zetterberg, Henrik, Gispert, Juan D, Molinuevo, José L

“…Research into hippocampal self-regulation abilities may help determine the clinical significance of hippocampal hyperactivity throughout the pathophysiological…”
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White matter hyperintensities mediate gray matter volume and processing speed relationship in cognitively unimpaired participants by Brugulat‐Serrat, Anna, Salvadó, Gemma, Operto, Grégory, Cacciaglia, Raffaele, Sudre, Carole H., Grau‐Rivera, Oriol, Suárez‐Calvet, Marc, Falcon, Carles, Sánchez‐Benavides, Gonzalo, Gramunt, Nina, Minguillon, Carolina, Fauria, Karine, Barkhof, Frederik, Molinuevo, José L., Gispert, Juan D.

“…White matter hyperintensities (WMH) have been extensively associated with cognitive impairment and reductions in gray matter volume (GMv) independently. This…”
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Changes in cerebral [18F]-FDG uptake induced by acute alcohol administration in a rat model of alcoholism by Gispert, Juan D., Figueiras, Francisca P., Vengeliene, Valentina, Herance, José R., Rojas, Santiago, Spanagel, Rainer

“…Several [18F]-FDG positron emission tomography (PET) studies in alcoholics have consistently reported decreases in overall brain glucose metabolism at rest and…”
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