Search Results - "Giselle Pentón-Rol"

Nutraceutical and therapeutic potential of Phycocyanobilin for treating Alzheimer’s disease by Matamoros, Beatriz Piniella, Prida, Javier Marin, Rol, Giselle Penton

“…Alzheimer’s disease (AD) is a devastating neurodegenerative condition provoking the loss of cognitive and memory performances. Despite huge efforts to develop…”
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C-Phycocyanin-derived Phycocyanobilin as a Potential Nutraceutical Approach for Major Neurodegenerative Disorders and COVID-19- induced Damage to the Nervous System by Pentón-Rol, Giselle, Marín-Prida, Javier, McCarty, Mark F

“…The edible cyanobacterium Spirulina platensis and its chief biliprotein C-Phycocyanin have shown protective activity in animal models of diverse human health…”
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Phycocyanobilin reduces brain injury after endothelin‐1‐ induced focal cerebral ischaemia by Pavón‐Fuentes, Nancy, Marín‐Prida, Javier, Llópiz‐Arzuaga, Alexey, Falcón‐Cama, Viviana, Campos‐Mojena, Rosario, Cervantes‐Llanos, Majel, Piniella‐Matamoros, Beatriz, Pentón‐Arias, Eduardo, Pentón‐Rol, Giselle

“…Pharmacological therapies for interrupting biochemical events of the ischaemic cascade and protecting against stroke in humans are as yet unavailable. Up to…”
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Anti-inflammatory mechanisms and pharmacological actions of phycocyanobilin in a mouse model of experimental autoimmune encephalomyelitis: A therapeutic promise for multiple sclerosis by Marín-Prida, Javier, Pavón-Fuentes, Nancy, Lagumersindez-Denis, Nielsen, Camacho-Rodríguez, Hanlet, García-Soca, Ana Margarita, Sarduy-Chávez, Rocío de la Caridad, Vieira, Érica Leandro Marciano, Carvalho-Tavares, Juliana, Falcón-Cama, Viviana, Fernández-Massó, Julio Raúl, Hernández-González, Ignacio, Martínez-Donato, Gillian, Guillén-Nieto, Gerardo, Pentón-Arias, Eduardo, Teixeira, Mauro Martins, Pentón-Rol, Giselle

“…Cytokines, demyelination and neuroaxonal degeneration in the central nervous system are pivotal elements implicated in the pathogenesis of multiple sclerosis…”
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C-Phycocyanin and Phycocyanobilin as Remyelination Therapies for Enhancing Recovery in Multiple Sclerosis and Ischemic Stroke: A Preclinical Perspective by Pentón-Rol, Giselle, Marín-Prida, Javier, Falcón-Cama, Viviana

“…Myelin loss has a crucial impact on behavior disabilities associated to Multiple Sclerosis (MS) and Ischemic Stroke (IS). Although several MS therapies are…”
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Report on the Symposium "Molecular Mechanisms Involved in Neurodegeneration" by Pentón-Rol, Giselle, Cervantes-Llanos, Majel

“…The prevalence of neurodegenerative diseases is currently a major concern in public health because of the lack of neuroprotective and neuroregenerative drugs…”
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Positive effects of Phycocyanobilin on gene expression in glutamate-induced excitotoxicity in SH-SY5Y cells and animal models of multiple sclerosis and cerebral ischemia by Gardón, Daniel Palenzuela, Cervantes-Llanos, Majel, Matamoros, Beatriz Piniella, Rodríguez, Hanlet Camacho, Tan, Chan-yuan, Marín –Prida, Javier, Falcón-Cama, Viviana, Pavón-Fuentes, Nancy, Lemus, Jessica Gómez, Ruiz, Laura de la Caridad Bakos, Argudin, Tamara Díaz, Donato, Gillian Martínez, Perera, Yasser, Yang, Ke, Pentón-Rol, Giselle

“…Oxidative stress has a predominant role in the pathogenesis of neurodegenerative diseases and therefore the modulation of genes and the identification of…”
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Beneficial effects of oral administration of C-Phycocyanin and Phycocyanobilin in rodent models of experimental autoimmune encephalomyelitis by Cervantes-Llanos, Majel, Lagumersindez-Denis, Nielsen, Marín-Prida, Javier, Pavón-Fuentes, Nancy, Falcon-Cama, Viviana, Piniella-Matamoros, Beatriz, Camacho-Rodríguez, Hanlet, Fernández-Massó, Julio Raúl, Valenzuela-Silva, Carmen, Raíces-Cruz, Ivette, Pentón-Arias, Eduardo, Teixeira, Mauro Martins, Pentón-Rol, Giselle

“…The only three oral treatments currently available for multiple sclerosis (MS) target the relapsing forms of the disease and concerns regarding efficacy,…”
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The effects of Phycocyanobilin on experimental arthritis involve the reduction in nociception and synovial neutrophil infiltration, inhibition of cytokine production, and modulation of the neuronal proteome by Marín-Prida, Javier, Rodríguez-Ulloa, Arielis, Besada, Vladimir, Llopiz-Arzuaga, Alexey, Batista, Nathália Vieira, Hernández-González, Ignacio, Pavón-Fuentes, Nancy, Marciano Vieira, Érica Leandro, Falcón-Cama, Viviana, Acosta, Emilio F., Martínez-Donato, Gillian, Cervantes-Llanos, Majel, Lingfeng, Dai, González, Luis J., Fernández-Massó, Julio Raúl, Guillén-Nieto, Gerardo, Pentón-Arias, Eduardo, Amaral, Flávio Almeida, Teixeira, Mauro Martins, Pentón-Rol, Giselle

“…Introduction The antinociceptive and pharmacological activities of C-Phycocyanin (C-PC) and Phycocyanobilin (PCB) in the context of inflammatory arthritis…”
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C-Phycocyanin is neuroprotective against global cerebral ischemia/reperfusion injury in gerbils by Pentón-Rol, Giselle, Marín-Prida, Javier, Pardo-Andreu, Gilberto, Martínez-Sánchez, Gregorio, Acosta-Medina, Emilio Felino, Valdivia-Acosta, Alain, Lagumersindez-Denis, Nielsen, Rodríguez-Jiménez, Efraín, Llópiz-Arzuaga, Alexey, López-Saura, Pedro Antonio, Guillén-Nieto, Gerardo, Pentón-Arias, Eduardo

“…Highlights ► C-Phycocyanin (C-PC) prevents gerbil brain ischemia–reperfusion injury (IRI). ► C-PC reduces infarct volume and hippocampal cell death induced by…”
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Comparative Neuroregenerative Effects of C-Phycocyanin and IFN-Beta in a Model of Multiple Sclerosis in Mice by Pentón-Rol, Giselle, Lagumersindez-Denis, Nielsen, Muzio, Luca, Bergami, Alessandra, Furlan, Roberto, Fernández-Massó, Julio R., Nazabal-Galvez, Marcelo, Llópiz-Arzuaga, Alexey, Herrera-Rolo, Tania, Veliz-Rodriguez, Tania, Polentarutti, Nadia, Marín-Prida, Javier, Raíces-Cruz, Ivette, Valenzuela-Silva, Carmen, Teixeira, Mauro Martins, Pentón-Arias, Eduardo

“…Multiple Sclerosis (MS) therapies approved so far are unable to effectively reverse the chronic phase of the disease or improve the remyelination process. Here…”
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Construction, purification, and characterization of a chimeric TH1 antagonist by Bello-Rivero, Iraldo, Torrez-Ruiz, Yeny, Blanco-Garcés, Elizabeth, Pentón-Rol, Giselle, Fernández-Batista, Osmani, Javier-González, Luís, Gerónimo-Perez, Haydee, López-Saura, Pedro

“…TH1 immune response antagonism is a desirable approach to mitigate some autoimmune and inflammatory reactions during the course of several diseases where IL-2…”
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Potencialidades de la microscopía en la investigación del SARS-CoV-2: aislamiento, fisiopatogénesis y dianas terapéuticas by Falcón Cama, Viviana, Pentón Rol, Giselle, Montero González, Teresita de Jesús, Acosta Rivero, Nelson, Guillén Nieto, Gerardo, Acosta Medina, Emilio Felino, Cremata García, Daina, Matos Terrero, Mariuska, Fernández Ortega, Celia, Oramas Díaz, Leonardo, Mondeja Rodríguez, Brian, Blanco Águila, Omar Reinaldo, Suárez Batista, Anamary, Noa Romero, Enrique, Valdés Veliz, Rodolfo, Díaz García, Angelina, González Alfaro, Yorexis

“…RESUMEN Introducción: La identificación del amplio tropismo del SARS-CoV-2 puede ser crítico para la patogénesis viral, por lo que es relevante conocer los…”
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Editorial: Women in cytokines and soluble mediators in immunity by Boraschi, Diana, Penton-Rol, Giselle, Amodu, Olukemi, Blomberg, Marita Troye

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TNF-alpha and IL-10 downregulation and marked oxidative stress in Neuromyelitis Optica by Pentón-Rol, Giselle, Cervantes-Llanos, Majel, Martínez-Sánchez, Gregorio, Cabrera-Gómez, José A, Valenzuela-Silva, Carmen M, Ramírez-Nuñez, Omar, Casanova-Orta, Mayté, Robinson-Agramonte, María A, Lopategui-Cabezas, Ileana, López-Saura, Pedro A

“…Neuromyelitis optica is a central nervous system demyelinating and inflammatory syndrome. The objective of this study is to identify cytokines related to the…”
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The microglial NLRP3 inflammasome is involved in human SARS-CoV-2 cerebral pathogenicity: A report of three post-mortem cases by Cama, Viviana Falcón, Marín-Prida, Javier, Acosta-Rivero, Nelson, Acosta, Emilio F., Díaz, Leonardo Oramas, Casadesús, Ana V., Fernández-Marrero, Briandy, Gilva-Rodríguez, Nathalie, Cremata-García, Daina, Cervantes-Llanos, Majel, Piniella-Matamoros, Beatriz, Sánchez, Daisy, del Rosario-Cruz, Leticia, Borrajero, Israel, Díaz, Angelina, González, Yorexis, Pentón-Arias, Eduardo, Montero-González, Teresita, Guillen-Nieto, Gerardo, Pentón-Rol, Giselle

“…We herein report, by using confocal immunofluorescence, the colocalization of the SARS-CoV-2 nucleocapsid within neurons, astrocytes, oligodendrocytes and…”
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Phycocyanobilin promotes PC12 cell survival and modulates immune and inflammatory genes and oxidative stress markers in acute cerebral hypoperfusion in rats by Marín-Prida, Javier, Pavón-Fuentes, Nancy, Llópiz-Arzuaga, Alexey, Fernández-Massó, Julio R., Delgado-Roche, Liván, Mendoza-Marí, Yssel, Santana, Seydi Pedroso, Cruz-Ramírez, Alieski, Valenzuela-Silva, Carmen, Nazábal-Gálvez, Marcelo, Cintado-Benítez, Alberto, Pardo-Andreu, Gilberto L., Polentarutti, Nadia, Riva, Federica, Pentón-Arias, Eduardo, Pentón-Rol, Giselle

“…Since the inflammatory response and oxidative stress are involved in the stroke cascade, we evaluated here the effects of Phycocyanobilin (PCB, the…”
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Differential Expression and Regulation of Toll-Like Receptors (TLR) in Human Leukocytes: Selective Expression of TLR3 in Dendritic Cells by Muzio, Marta, Bosisio, Daniela, Polentarutti, Nadia, D'amico, Giovanna, Stoppacciaro, Antonella, Mancinelli, Roberta, van't Veer, Cornelis, Penton-Rol, Giselle, Ruco, Luigi P, Allavena, Paola, Mantovani, Alberto

“…Members of the Toll-like receptor (TLR) family probably play a fundamental role in pathogen recognition and activation of innate immunity. The present study…”
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C-Phycocyanin-derived Phycocyanobilin as a Potential Nutraceutical Approach for Major Neurodegenerative Disorders and COVID-19- induced Damage to the Nervous System by Giselle Pentón-Rol, Javier Marín-Prida, Mark F. McCarty

“…The edible cyanobacterium Spirulina platensis and its chief biliprotein C-Phycocyaninhave shown protective activity in animal models of diverse human health…”
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C-Phycocyanin protects SH-SY5Y cells from oxidative injury, rat retina from transient ischemia and rat brain mitochondria from Ca2+ /phosphate-induced impairment by Marín-Prida, Javier, Pentón-Rol, Giselle, Rodrigues, Fernando Postalli, Alberici, Luciane Carla, Stringhetta, Karina, Leopoldino, Andréia Machado, Naal, Zeki, Polizello, Ana Cristina Morseli, Llópiz-Arzuaga, Alexey, Rosa, Marcela Nunes, Liberato, José Luiz, Santos, Wagner Ferreira dos, Uyemura, Sergio Akira, Pentón-Arias, Eduardo, Curti, Carlos, Pardo-Andreu, Gilberto L

“…Highlights ► C-Phycocyanin (C-PC) prevented tert -butylhydroperoxide injury in SH-SY5Y cells. ► C-PC protected the retina against elevated intraocular…”
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