Search Results - "Giscombe, R."

A CTLA-4 gene polymorphism at position −318 in the promoter region affects the expression of protein by Wang, X B, Zhao, X, Giscombe, R, Lefvert, A K

“…CTLA-4 is an important negative regulator of the immune system. The regulation of the CTLA-4 gene (Ctla-4) transcription is poorly understood. A single…”
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Two SNPs in the promoter region of the CTLA‐4 gene affect binding of transcription factors and are associated with human myasthenia gravis by Wang, XB, Pirskanen, R., Giscombe, R., Lefvert, A. K.

“… Objectives.  The molecular mechanisms underlying the regulation of the CD152 (CTLA‐4) gene are largely unknown. Two single nucleotide polymorphisms (SNPs)…”
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Human Soluble CD80 is Generated by Alternative Splicing, and Recombinant Soluble CD80 Binds to CD28 and CD152 Influencing T-cell Activation by Kakoulidou, M, Giscombe, R, Zhao, X, Lefvert, A.K, Wang, X

“…CD80 is a costimulatory factor mainly expressed on the surface of activated monocytes, B cells and dendritic cells. In this study, we demonstrate that 24% of…”
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Expression of CTLA‐4 by Human Monocytes by Wang, X.‐B., Giscombe, R., Yan, Z., Heiden, T., Xu, D., Lefvert, A. K.

“…Cytotoxic T lymphocyte‐associated molecule‐4 (CTLA‐4) is a receptor present on T cells that plays a critical role in the downregulation of antigen‐activated…”
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Characterization of the expanded T‐cell populations in patients with Wegener's granulomatosis by GISCOMBE, R., WANG, X. B., KAKOULIDOU, M., LEFVERT, A. K.

“… Objectives.  Wegener's granulomatosis (WG) is a chronic inflammatory disease characterized by granulomatosis inflammation, systemic vasculitis and…”
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The use of clinical decision support in reducing readmissions for patients with heart failure: a quasi-experimental study by Giscombe, Susan R., Baptiste, Diana-Lyn, Koirala, Binu, Asano, Reiko, Commodore-Mensah, Yvonne

“…Heart failure is a chronic, progressive condition which affects over six million Americans and 26 million people worldwide. Evidence-based guidelines,…”
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Regulation of Surface and Intracellular Expression of CTLA‐4 on Human Peripheral T Cells by Wang, X.‐B., Zheng, C.‐Y., Giscombe, R., Lefvert, A. K.

“…Cytotoxic T‐lymphocyte‐associated antigen (CTLA‐4) is an important downregulator of T‐cell activation. In order to analyze the expression and regulation of…”
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Circulating CD4+CD25+ and CD4+CD25– T Cells in Myasthenia Gravis and in Relation to Thymectomy by Huang, Y.‐M., Pirskanen, R., Giscombe, R., Link, H., Lefvert, A.‐K.

“…Studies in experimental animal models of human autoimmune diseases have revealed that CD4+CD25+ T regulatory (Tr) cells are of thymic origin and have…”
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The autoimmune T and B cell repertoires in monozygotic twins discordant for myasthenia gravis by Kakoulidou, M., Åhlberg, R., Yi, Q., Giscombe, R., Pirskanen, R., Lefvert, A.K.

“…Two pairs of monozygotic twins, discordant for myasthenia gravis (MG) for more than 30 years, were studied regarding T cell and antibody reactivity against…”
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CDS1 and promoter single nucleotide polymorphisms of the CTLA-4 gene in human myasthenia gravis by Wang, X B, Kakoulidou, M, Qiu, Q, Giscombe, R, Huang, DeRen, Pirskanen, R, Lefvert, A K

“…The cytotoxic T lymphocyte associated protein 4 (CTLA-4) gene (Ctla-4) is a candidate gene for autoimmune disease. We here report results of two single…”
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T cell receptor (TCR) V gene usage in patients with systemic necrotizing vasculitis by GISCOMBE, R., GRUNEWALD, J., NITYANAND, S., LEFVERT, A. K.

“…SUMMARY Wegener's granulomatosis (WG) and polyarteritis nodosa (PAN) are systemic necrotizing vasculitides of unknown etiology. These disorders run a fatal…”
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Polymorphism in tumor necrosis factor genes associated with myasthenia gravis by Hjelmström, P, Peacock, C.S, Giscombe, R, Pirskanen, R, Lefvert, A.K, Blackwell, J.M, Sanjeevi, C.B

“…The aim of this study was to analyze associations between myasthenia gravis (MG) and polymorphisms in the tumor necrosis factor (TNF) region in 79 Swedish…”
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A bias in the αβ T cell receptor variable region gene usage in Takayasu's arteritis by NITYANAND, S., GISCOMBE, R., SRIVASTAVA, S., HJELMSTRO¨M, P., SANJEEVI, C. B., SINHA, N., GRUNEWALD, J., LEFVERT, A. K.

“…Takayasu's arteritis (TA) is a chronic large vessel vasculitis with a predilection for the aortic arch and its branches. T lymphocytes may be important in the…”
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B7-H3 and B7-H4 expression in non-small-cell lung cancer by Sun, Yuping, Wang, Yunshan, Zhao, Jianqiang, Gu, Ming, Giscombe, Ricardo, Lefvert, Ann Kari, Wang, Xiongbiao

“…Inhibitory regulatory functions of B7-H3 and B7-H4 regarding T-cell activation have been reported recently. Little is known about the significance of human…”
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Myasthenia Gravis with Thymic Hyperplasia Is Associated with Polymorphisms in the Tumor Necrosis Factor Region by HJELMSTROM, P., PEACOCK, C. S., GISCOMBE, R., PIRSKANEN, R., LEFVERT, A. K., BLACKWELL, J. M., SANJEEVI, C. B.

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Abnormal T cell receptor V gene usage in myasthenia gravis: prevalence and characterization of expanded T cell populations by XU, B.-Y, GISCOMBE, R, SÖDERLUND, A, TROYE-BLOMBERG, M, PIRSKANEN, R, LEFVERT, A. K

“…The usage of T cell receptor (TCR) Vα/Vβ chains on cells from 38 patients with myasthenia gravis (MG) was determined by flow cytometry. There was a decreased…”
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Induction of human cytotoxic T lymphocytes by oxidized low density lipoproteins by Wu, R, Giscombe, R, Holm, G, Lefvert, A K

“…Oxidized low density lipoproteins (oxLDL) stimulated human blood T cells to a specific cytotoxic response with autologous PHA activated blood mononuclear cells…”
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Abnormal expression of CTLA-4 by T cells from patients with myasthenia gravis: effect of an AT-rich gene sequence by Wang, Xiong-Biao, Kakoulidou, Maria, Giscombe, Ricardo, Qiu, Qianhui, Huang, DeRen, Pirskanen, Ritva, Lefvert, Ann Kari

“…Cytolytic T lymphocyte-associated antigen-4 (CTLA-4) plays a critical role in the down-regulation of antigen-activated immune responses. The aberrant CTLA-4…”
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Increased luminol‐enhanced chemiluminescence of blood monocytes and granulocytes in Hodgkin's disease by TULLGREN, O., GISCOMBE, R., HOLM, G., JOHANSSON, B., MELLSTEDT, H., BJÖRKHOLM, M.

“…SUMMARY The oxidative metabolic burst of blood monocytes and polymorphonuclear leukocytes (PMN) from 22 untreated patients with Hodgkin's disease (HD) and 18…”
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Identification of CTLA-4 isoforms produced by alternative splicing and their association with myasthenia gravis by Gu, Ming, Kakoulidou, Maria, Giscombe, Ricardo, Pirskanen, Ritva, Lefvert, Ann Kari, Klareskog, Lars, Wang, XiongBiao

“…Abstract Myasthenia gravis (MG) is an autoimmune disease characterized by muscle weakness induced by autoantibodies against the acetylcholine receptor. CTLA-4…”
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