Search Results - "Giroud, Maude"

Long Non-Coding RNAs in Metabolic Organs and Energy Homeostasis by Giroud, Maude, Scheideler, Marcel

“…Single cell organisms can surprisingly exceed the number of human protein-coding genes, which are thus not at the origin of the complexity of an organism. In…”
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Drug Discovery Efforts to Identify Novel Treatments for Neglected Tropical Diseases - Cysteine Protease Inhibitors by Giroud, Maude, Kuhn, Bernd, Haap, Wolfgang

“…Neglected tropical diseases are a severe burden for mankind, affecting an increasing number of people around the globe. Many of those diseases are caused by…”
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Impact of dietary ω3 polyunsaturated fatty acid supplementation on brown and brite adipocyte function by Ghandour, Rayane A., Colson, Cecilia, Giroud, Maude, Maurer, Stefanie, Rekima, Samah, Ailhaud, Gérard, Klingenspor, Martin, Amri, Ez-Zoubir, Pisani, Didier F.

“…The recent characterization of functional brown adipose tissue in adult humans has opened new perspectives for regulation of energy expenditure with respect to…”
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Arynes and Cyclic Alkynes as Synthetic Building Blocks for Stereodefined Quaternary Centers by Picazo, Elias, Anthony, Sarah M, Giroud, Maude, Simon, Adam, Miller, Margeaux A, Houk, K. N, Garg, Neil K

“…We report a facile method to synthesize stereodefined quaternary centers from reactions of arynes and related strained intermediates using β-ketoester-derived…”
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Mitochondrial fission is associated with UCP1 activity in human brite/beige adipocytes by Pisani, Didier F, Barquissau, Valentin, Chambard, Jean-Claude, Beuzelin, Diane, Ghandour, Rayane A, Giroud, Maude, Mairal, Aline, Pagnotta, Sophie, Cinti, Saverio, Langin, Dominique, Amri, Ez-Zoubir

“…Thermogenic adipocytes (i.e. brown or brite/beige adipocytes) are able to burn large amounts of lipids and carbohydrates as a result of highly active…”
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HAND2 is a novel obesity-linked adipogenic transcription factor regulated by glucocorticoid signalling by Giroud, Maude, Tsokanos, Foivos-Filippos, Caratti, Giorgio, Kotschi, Stefan, Khani, Sajjad, Jouffe, Céline, Vogl, Elena S., Irmler, Martin, Glantschnig, Christina, Gil-Lozano, Manuel, Hass, Daniela, Khan, Asrar Ali, Garcia, Marcos Rios, Mattijssen, Frits, Maida, Adriano, Tews, Daniel, Fischer-Posovszky, Pamela, Feuchtinger, Annette, Virtanen, Kirsi A., Beckers, Johannes, Wabitsch, Martin, Uhlenhaut, Henriette, Blüher, Matthias, Tuckermann, Jan, Scheideler, Marcel, Bartelt, Alexander, Herzig, Stephan

“…Aims/hypothesis Adipocytes are critical cornerstones of energy metabolism. While obesity-induced adipocyte dysfunction is associated with insulin resistance…”
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Norepinephrine triggers an immediate-early regulatory network response in primary human white adipocytes by Higareda-Almaraz, Juan Carlos, Karbiener, Michael, Giroud, Maude, Pauler, Florian M, Gerhalter, Teresa, Herzig, Stephan, Scheideler, Marcel

“…Norepinephrine (NE) signaling has a key role in white adipose tissue (WAT) functions, including lipolysis, free fatty acid liberation and, under certain…”
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IP-receptor and PPARs trigger the conversion of human white to brite adipocyte induced by carbaprostacyclin by Ghandour, Rayane A., Giroud, Maude, Vegiopoulos, Alexandros, Herzig, Stephan, Ailhaud, Gérard, Amri, Ez-Zoubir, Pisani, Didier F.

“…Brite adipocytes recently discovered in humans are of considerable importance in energy expenditure by converting energy excess into heat. This property could…”
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Chemoenzymatic conversion of amides to enantioenriched alcohols in aqueous medium by Dander, Jacob E., Giroud, Maude, Racine, Sophie, Darzi, Evan R., Alvizo, Oscar, Entwistle, David, Garg, Neil K.

“…One-pot reactions that combine non-enzymatic and biocatalytic transformations represent an emerging strategy in chemical synthesis. Some of the most powerful…”
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Trip13 Depletion in Liver Cancer Induces a Lipogenic Response Contributing to Plin2‐Dependent Mitotic Cell Death by Rios Garcia, Marcos, Meissburger, Bettina, Chan, Jessica, Guia, Roldan M., Mattijssen, Frits, Roessler, Stephanie, Birkenfeld, Andreas L., Raschzok, Nathanael, Riols, Fabien, Tokarz, Janina, Giroud, Maude, Gil Lozano, Manuel, Hartleben, Goetz, Nawroth, Peter, Haid, Mark, López, Miguel, Herzig, Stephan, Berriel Diaz, Mauricio

“…Aberrant energy metabolism and cell cycle regulation both critically contribute to malignant cell growth and both processes represent targets for anticancer…”
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miR-125b affects mitochondrial biogenesis and impairs brite adipocyte formation and function by Giroud, Maude, Pisani, Didier F, Karbiener, Michael, Barquissau, Valentin, Ghandour, Rayane A, Tews, Daniel, Fischer-Posovszky, Pamela, Chambard, Jean-Claude, Knippschild, Uwe, Niemi, Tarja, Taittonen, Markku, Nuutila, Pirjo, Wabitsch, Martin, Herzig, Stephan, Virtanen, Kirsi A, Langin, Dominique, Scheideler, Marcel, Amri, Ez-Zoubir

“…Abstract Objective In rodents and humans, besides brown adipose tissue (BAT), islands of thermogenic adipocytes, termed “brite” (brown-in-white) or beige…”
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The ω6-fatty acid, arachidonic acid, regulates the conversion of white to brite adipocyte through a prostaglandin/calcium mediated pathway by Pisani, Didier F, Ghandour, Rayane A, Beranger, Guillaume E, Le Faouder, Pauline, Chambard, Jean-Claude, Giroud, Maude, Vegiopoulos, Alexandros, Djedaini, Mansour, Bertrand-Michel, Justine, Tauc, Michel, Herzig, Stephan, Langin, Dominique, Ailhaud, Gérard, Duranton, Christophe, Amri, Ez-Zoubir

“…Abstract Objective Brite adipocytes are inducible energy-dissipating cells expressing UCP1 which appear within white adipose tissue of healthy adult…”
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Replacement of Water Molecules in a Phosphate Binding Site by Furanoside-Appended lin-Benzoguanine Ligands of tRNA-Guanine Transglycosylase (TGT) by Barandun, Luzi J., Ehrmann, Frederik R., Zimmerli, Daniel, Immekus, Florian, Giroud, Maude, Grünenfelder, Claudio, Schweizer, W. Bernd, Bernet, Bruno, Betz, Michael, Heine, Andreas, Klebe, Gerhard, Diederich, François

“…The enzyme tRNA‐guanine transglycosylase has been identified as a drug target for the foodborne illness shigellosis. A key challenge in structure‐based design…”
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Adipocyte function and the development of cardiometabolic disease by Giroud, Maude, Jodeleit, Henrika, Prentice, Kacey J., Bartelt, Alexander

“…Obesity is a medical disorder caused by multiple mechanisms of dysregulated energy balance. A major consequence of obesity is an increased risk to develop…”
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Intercepting fleeting cyclic allenes with asymmetric nickel catalysis by Yamano, Michael M., Kelleghan, Andrew V., Shao, Qianzhen, Giroud, Maude, Simmons, Bryan J., Li, Bo, Chen, Shuming, Houk, K. N., Garg, Neil K.

“…Strained cyclic organic molecules, such as arynes, cyclic alkynes and cyclic allenes, have intrigued chemists for more than a century with their unusual…”
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Prospective Evaluation of Free Energy Calculations for the Prioritization of Cathepsin L Inhibitors by Kuhn, Bernd, Tichý, Michal, Wang, Lingle, Robinson, Shaughnessy, Martin, Rainer E, Kuglstatter, Andreas, Benz, Jörg, Giroud, Maude, Schirmeister, Tanja, Abel, Robert, Diederich, François, Hert, Jérôme

“…Improving the binding affinity of a chemical series by systematically probing one of its exit vectors is a medicinal chemistry activity that can benefit from…”
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Development of a peptide drug restoring AMPK and adipose tissue functionality in cancer cachexia by Ji, Honglei, Englmaier, Felix, Morigny, Pauline, Giroud, Maude, Gräsle, Pamina, Brings, Sebastian, Szendrödi, Julia, Berriel Diaz, Mauricio, Plettenburg, Oliver, Herzig, Stephan, Rohm, Maria

“…Cancer cachexia is a severe systemic wasting disease that negatively affects quality of life and survival in patients with cancer. To date, treating cancer…”
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A miR‐29a‐driven negative feedback loop regulates peripheral glucocorticoid receptor signaling by Glantschnig, Christina, Koenen, Mascha, Gil‐Lozano, Manuel, Karbiener, Michael, Pickrahn, Ines, Williams‐Dautovich, Jasmine, Patel, Rucha, Cummins, Carolyn L., Giroud, Maude, Hartleben, Götz, Vogl, Elena, Blüher, Matthias, Tuckermann, Jan, Uhlenhaut, Henriette, Herzig, Stephan, Scheideler, Marcel

“…ABSTRACTThe glucocorticoid receptor (GR) represents the crucial molecular mediator of key endocrine, glucocorticoid hormone–dependent regulatory circuits,…”
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Inhibition of the Cysteine Protease Human Cathepsin L by Triazine Nitriles: Amide⋅⋅⋅Heteroarene π‐Stacking Interactions and Chalcogen Bonding in the S3 Pocket by Giroud, Maude, Ivkovic, Jakov, Martignoni, Mara, Fleuti, Marianne, Trapp, Nils, Haap, Wolfgang, Kuglstatter, Andreas, Benz, Jörg, Kuhn, Bernd, Schirmeister, Tanja, Diederich, François

“…We report an extensive “heteroarene scan” of triazine nitrile ligands of the cysteine protease human cathepsin L (hCatL) to investigate π‐stacking on the…”
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Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors by Giroud, Maude, Dietzel, Uwe, Anselm, Lilli, Banner, David, Kuglstatter, Andreas, Benz, Jörg, Blanc, Jean-Baptiste, Gaufreteau, Delphine, Liu, Haixia, Lin, Xianfeng, Stich, August, Kuhn, Bernd, Schuler, Franz, Kaiser, Marcel, Brun, Reto, Schirmeister, Tanja, Kisker, Caroline, Diederich, François, Haap, Wolfgang

“…Rhodesain (RD) is a parasitic, human cathepsin L (hCatL) like cysteine protease produced by Trypanosoma brucei (T. b.) species and a potential drug target for…”
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