Factors That Determine the Adhesive Strength in a Bioinspired Bone Tissue Adhesive

Factors That Determine the Adhesive Strength in a Bioinspired Bone Tissue Adhesive

Phosphoserine-modified cements (PMCs) are a family of wet-field tissue adhesives that bond strongly to bone and biomaterials. The present study evaluated variations in the adhesive strength using a scatter plot, failure mode, and a regression analysis of eleven factors. All single-factor, continuous...

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Bibliographic Details
Published in:ChemEngineering Vol. 4; no. 1; p. 19
Main Authors: Pujari-Palmer, Michael, Giro, Roger, Procter, Philip, Bojan, Alicja, Insley, Gerard, Engqvist, Hakan
Format: Journal Article
Language:English
Published: Basel MDPI AG 01-03-2020
Subjects:
Adhesion
Adhesion tests
Adhesive bonding
Adhesive strength
Aluminum
Bioadhesives
Biomaterial
Biomaterials Science
Biomaterialvetenskap
Biomedical adhesives for clinical applications
Biomedical materials
Bond strength
Bonding strength
Bone adhesive
Bones
Cements
Chemical engineering
Chemical properties
Composition
Computational fluid dynamics
Continuity (mathematics)
Curing
Failure analysis
Failure modes
Fixation
Fractures
Hydroxyapatite
inorganic combinations
Investigations
Laboratories
Linear regression
Metal surfaces
organic
Organic/inorganic combinations
Particle size
Phosphoserine calcium phosphate
Regression analysis
Regression models
Regulatory approval
Shear strength
Shear tests
Stress concentration
Surface layers
Surface roughness
Surgeons
Testing
Tissue adhesive
Underwater adhesives
Unevenness
Sweden
United States > US
Germany
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Description
Summary:Phosphoserine-modified cements (PMCs) are a family of wet-field tissue adhesives that bond strongly to bone and biomaterials. The present study evaluated variations in the adhesive strength using a scatter plot, failure mode, and a regression analysis of eleven factors. All single-factor, continuous-variable correlations were poor (R2 < 0.25). The linear regression model explained 31.6% of variation in adhesive strength (R2 = 0.316 p < 0.001), with bond thickness predicting an 8.5% reduction in strength per 100 μm increase. Interestingly, PMC adhesive strength was insensitive to surface roughness (Sa 1.27–2.17 μm) and the unevenness (skew) of the adhesive bond (p > 0.167, 0.171, ANOVA). Bone glued in conditions mimicking the operating theatre (e.g., the rapid fixation and minimal fixation force in fluids) produced comparable adhesive strength in laboratory conditions (2.44 vs. 1.96 MPa, p > 0.986). The failure mode correlated strongly with the adhesive strength; low strength PMCs (<1 MPa) failed cohesively, while high strength (>2 MPa) PMCs failed adhesively. Failure occurred at the interface between the amorphous surface layer and the PMC bulk. PMC bonding is sufficient for clinical application, allowing for a wide tolerance in performance conditions while maintaining a minimal bond strength of 1.5–2 MPa to cortical bone and metal surfaces.
ISSN:2305-7084
2305-7084
DOI:10.3390/chemengineering4010019