Search Results - "Giridhar, S"

Pegbelfermin (BMS‐986036), PEGylated FGF21, in Patients with Obesity and Type 2 Diabetes: Results from a Randomized Phase 2 Study by Charles, Edgar D., Neuschwander‐Tetri, Brent A., Pablo Frias, Juan, Kundu, Sudeep, Luo, Yi, Tirucherai, Giridhar S., Christian, Rose

“…Objective Obesity and type 2 diabetes mellitus (T2DM) are risk factors for nonalcoholic fatty liver disease, including nonalcoholic steatohepatitis. This study…”
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Safety of the tau-directed monoclonal antibody BIIB092 in progressive supranuclear palsy: a randomised, placebo-controlled, multiple ascending dose phase 1b trial by Boxer, Adam L, Qureshi, Irfan, Ahlijanian, Michael, Grundman, Michael, Golbe, Lawrence I, Litvan, Irene, Honig, Lawrence S, Tuite, Paul, McFarland, Nikolaus R, O'Suilleabhain, Padraig, Xie, Tao, Tirucherai, Giridhar S, Bechtold, Clifford, Bordelon, Yvette, Geldmacher, David S, Grossman, Murray, Isaacson, Stuart, Zesiewicz, Theresa, Olsson, Tina, Muralidharan, Kumar Kandadi, Graham, Danielle L, O'Gorman, John, Haeberlein, Samantha Budd, Dam, Tien

“…Progressive supranuclear palsy is a rare neurodegenerative disease associated with dysfunctional tau protein. BIIB092 is a humanised monoclonal antibody that…”
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BMS‐986263 in patients with advanced hepatic fibrosis: 36‐week results from a randomized, placebo‐controlled phase 2 trial by Lawitz, Eric J., Shevell, Diane E., Tirucherai, Giridhar S., Du, Shuyan, Chen, Warner, Kavita, Uma, Coste, Angie, Poordad, Fred, Karsdal, Morten, Nielsen, Mette, Goodman, Zachary, Charles, Edgar D.

“…Background and Aims Hepatic fibrosis secondary to HCV infection can lead to cirrhosis and hepatic decompensation. Sustained virologic response (SVR) is…”
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Drilling of GFRP with Liquid Silicon Rubber Reinforced with fine Aluminium Powder on Hole Surface Quality and Tool Wear using DOE by Kulkarni, Giridhar S., Siddeshkumar, N. G., Prasad, C. Durga, Shankar, Latha, Suresh, R.

“…The efforts are made to study the effect of machining parameters: speed, feed, tool tip angle, and tool material on hole quality: surface finish, and tool…”
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Pegbelfermin in Patients With Nonalcoholic Steatohepatitis and Stage 3 Fibrosis (FALCON 1): A Randomized Phase 2b Study by Loomba, Rohit, Sanyal, Arun J., Nakajima, Atsushi, Neuschwander-Tetri, Brent A., Goodman, Zachary D., Harrison, Stephen A., Lawitz, Eric J., Gunn, Nadege, Imajo, Kento, Ravendhran, Natarajan, Akahane, Takemi, Boone, Bradly, Yamaguchi, Masayuki, Chatterjee, Arkendu, Tirucherai, Giridhar S., Shevell, Diane E., Du, Shuyan, Charles, Edgar D., Abdelmalek, Manal F.

“…Pegbelfermin is a polyethlene glycol–conjugated analog of human fibroblast growth factor 21, a nonmitogenic hormone that regulates energy metabolism. This…”
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Pegbelfermin in Patients With Nonalcoholic Steatohepatitis and Compensated Cirrhosis (FALCON 2): A Randomized Phase 2b Study by Abdelmalek, Manal F., Sanyal, Arun J., Nakajima, Atsushi, Neuschwander-Tetri, Brent A., Goodman, Zachary D., Lawitz, Eric J., Harrison, Stephen A., Jacobson, Ira M., Imajo, Kento, Gunn, Nadege, Halegoua-DeMarzio, Dina, Akahane, Takemi, Boone, Bradly, Yamaguchi, Masayuki, Chatterjee, Arkendu, Tirucherai, Giridhar S., Shevell, Diane E., Du, Shuyan, Charles, Edgar D., Loomba, Rohit

“…Pegbelfermin is a polyethylene glycol–conjugated analog of human fibroblast growth factor 21, a nonmitogenic hormone that regulates energy metabolism. This…”
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Severe Pulmonary Air Leak Complicating Neonatal Resuscitation by Supriya, ., Deepthi, Perumalla Bhavani, Giridhar, S

“…Air leaks are an important respiratory morbidity in neonates and can result from positive pressure breaths administered at birth. The presentations can vary…”
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MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity by Cheng, Dong, Zinker, Bradley A., Luo, Yi, Shipkova, Petia, De Oliveira, Claudia H., Krishna, Gopal, Brown, Elizabeth A., Boehm, Stephanie L., Tirucherai, Giridhar S., Gu, Huidong, Ma, Zhengping, Chu, Ching-Hsuen, Onorato, Joelle M., Kopcho, Lisa M., Ammar, Ron, Smith, Julia, Devasthale, Pratik, Lawrence, R. Michael, Stryker, Steven A., Dierks, Elizabeth A., Azzara, Anthony V., Carayannopoulos, Leon, Charles, Edgar D., Lentz, Kimberley A., Gordon, David A.

“…Monoacylglycerol acyltransferase 2 (MGAT2) is an important enzyme highly expressed in the human small intestine and liver for the regulation of triglyceride…”
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The FALCON program: Two phase 2b randomized, double-blind, placebo-controlled studies to assess the efficacy and safety of pegbelfermin in the treatment of patients with nonalcoholic steatohepatitis and bridging fibrosis or compensated cirrhosis by Abdelmalek, Manal F., Charles, Edgar D., Sanyal, Arun J., Harrison, Stephen A., Neuschwander-Tetri, Brent A., Goodman, Zachary, Ehman, Richard A., Karsdal, Morten, Nakajima, Atsushi, Du, Shuyan, Tirucherai, Giridhar S., Klinger, George H., Mora, Johanna, Yamaguchi, Masayuki, Shevell, Diane E., Loomba, Rohit

“…Nonalcoholic steatohepatitis (NASH) is the progressive form of nonalcoholic fatty liver disease (NAFLD); no approved therapies for NASH currently exist…”
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Phase 2 trial design of BMS-986278, a lysophosphatidic acid receptor 1 (LPA1) antagonist, in patients with idiopathic pulmonary fibrosis (IPF) or progressive fibrotic interstitial lung disease (PF-ILD) by Corte, Tamera J, Lancaster, Lisa, Swigris, Jeffrey J, Maher, Toby M, Goldin, Jonathan G, Palmer, Scott M, Suda, Takafumi, Ogura, Takashi, Minnich, Anne, Zhan, Xiaojiang, Tirucherai, Giridhar S, Elpers, Brandon, Xiao, Hong, Watanabe, Hideaki, Smith, R Adam, Charles, Edgar D, Fischer, Aryeh

“…IntroductionIdiopathic pulmonary fibrosis (IPF) and non-IPF, progressive fibrotic interstitial lung diseases (PF-ILD), are associated with a progressive loss…”
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Pharmacokinetics, safety, and tolerability of BMS‐986263, a lipid nanoparticle containing HSP47 siRNA, in participants with hepatic impairment by Qosa, Hisham, de Oliveira, Claudia H. M. C., Cizza, Giovanni, Lawitz, Eric J., Colletti, Nicholas, Wetherington, Jeffrey, Charles, Edgar D., Tirucherai, Giridhar S.

“…BMS‐986263 is a retinoid‐conjugated lipid nanoparticle delivering small interfering RNA designed to inhibit synthesis of HSP47 protein, a collagen‐specific…”
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Difference image analysis: extension to a spatially varying photometric scale factor and other considerations by Bramich, D. M., Horne, Keith, Albrow, M. D., Tsapras, Y., Snodgrass, C., Street, R. A., Hundertmark, M., Kains, Noé, Arellano, Ferro A., Figuera, Jaimes R., Giridhar, Sunetra

“…We present a general framework for matching the point-spread function (PSF), photometric scaling and sky background between two images, a subject which is…”
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Cobalt-Doped ZnO Nanocomposits for Efficient Dye Degradation: Charge Transfer by Abebe, Buzuayehu, Kefale, Bontu, Amenu, Guta, Guta, Leta, Ravikumar, C R, Hamdalla, Taymour A, Giridhar Reddy, S, Tsegaye, Dereje, Murthy, H C Ananda

“…Doping enhances the optical properties of high-band gap zinc oxide nanoparticles (ZnO NPs), essential for their photocatalytic activity. We used the combustion…”
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Controlled drug delivery studies of biological macromolecules: Sodium alginate and lignosulphonic acid films by Reddy, S. Giridhar, Pandit, Akanksha Saxena

“…ABSTRACT The ciprofloxacin (CPX)‐loaded blends made of sodium alginate and lignosulfonic acid (LS) were prepared by solution casting method in the ratio of…”
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Thermal Stability and Kinetics of Sodium Alginate and Lignosulphonic Acid Blends by S. Giridhar Reddy, A. Thakur

“…Biodegradable polymer blends are prepared by solution casting method by mixing Sodium alginate (SA) and Lignosulphonic acid (LS) biodegradable polymers. In…”
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Multiple fibro-osseous lesions of the jaws: A report of a rare case with a literature review by Makkad, Ramanpal Singh, Naidu, Giridhar S, Nagi, Ravleen, Sagtani, Alok, Patil, Santosh, Shrivastava, Swatantra

“…Fibro-osseous lesions are a poorly defined category of conditions affecting the jaws and craniofacial bones, and include developmental lesions, reactive or…”
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Fabricating transdermal film formulations of montelukast sodium with improved chemical stability and extended drug release by Aashli, Reddy, S. Giridhar, Siva Kumar, B., Prashanthi, K., Murthy, H.C. Ananda

“…Montelukast Sodium (MK) is a leukotriene receptor antagonist, an oral drug generally prescribed to control chronic asthma symptoms. This research aims to…”
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Botulinum toxin in the management of head and neck disorders by Nagi, Ravleen, BDS, MDS, Patil, Deepa Jatti, BDS, MDS, Sahu, Shashikant, MBBS, MS.Mch, Jain, Supreet, BDS, MDS, Naidu, Giridhar S., BDS, MDS

“…Botulinum toxin is a polypeptide protoxin synthesized by Clostridium botulinum that results in localized reduction of muscle activity by inhibiting…”
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Evaluating a Multiscale Mechanistic Model of the Immune System to Predict Human Immunogenicity for a Biotherapeutic in Phase 1 by Hamuro, Lora, Tirucherai, Giridhar S., Crawford, Sean M., Nayeem, Akbar, Pillutla, Renuka C., DeSilva, Binodh S., Leil, Tarek A., Thalhauser, Craig J.

“…A mechanistic model of the immune response was evaluated for its ability to predict anti-drug antibody (ADA) and their impact on pharmacokinetics (PK) and…”
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Switchable Electro-Optic Diffractive Lens with High Efficiency for Ophthalmic Applications by Li, Guoqiang, Mathine, David L., Valley, Pouria, Äyräs, Pekka, Haddock, Joshua N., Giridhar, M. S., Williby, Gregory, Schwiegerling, Jim, Meredith, Gerald R., Kippelen, Bernard, Honkanen, Seppo, Peyghambarian, Nasser

“…Presbyopia is an age-related loss of accommodation of the human eye that manifests itself as inability to shift focus from distant to near objects. Assuming no…”
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