Search Results - "Girgenti, Matthew"

Posttraumatic Stress Disorder Brain Transcriptomics: Convergent Genomic Signatures Across Biological Sex by Wang, Jiawei, Zhao, Hongyu, Girgenti, Matthew J.

“…While a definitive understanding of the molecular pathology of posttraumatic stress disorder (PTSD) is far from a current reality, it has become increasingly…”
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Stress and Its Impact on the Transcriptome by Girgenti, Matthew J., Pothula, Santosh, Newton, Samuel S.

“…Exposure to stress during the course of a lifetime is inevitable in the animal kingdom. It is the response to stress, the valence of the exposure, and the…”
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Transcriptomic organization of the human brain in post-traumatic stress disorder by Girgenti, Matthew J., Wang, Jiawei, Ji, Dingjue, Cruz, Dianne A., Stein, Murray B., Gelernter, Joel, Young, Keith A., Huber, Bertrand R., Williamson, Douglas E., Friedman, Matthew J., Krystal, John H., Zhao, Hongyu, Duman, Ronald S.

“…Despite extensive study of the neurobiological correlates of post-traumatic stress disorder (PTSD), little is known about its molecular determinants. Here,…”
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Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program by Stein, Murray B., Levey, Daniel F., Cheng, Zhongshan, Wendt, Frank R., Harrington, Kelly, Pathak, Gita A., Cho, Kelly, Quaden, Rachel, Radhakrishnan, Krishnan, Girgenti, Matthew J., Ho, Yuk-Lam Anne, Posner, Daniel, Aslan, Mihaela, Duman, Ronald S., Zhao, Hongyu, Polimanti, Renato, Concato, John, Gelernter, Joel

“…We conducted genome-wide association analyses of over 250,000 participants of European (EUR) and African (AFR) ancestry from the Million Veteran Program using…”
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GABA interneurons are the cellular trigger for ketamine's rapid antidepressant actions by Gerhard, Danielle M, Pothula, Santosh, Liu, Rong-Jian, Wu, Min, Li, Xiao-Yuan, Girgenti, Matthew J, Taylor, Seth R, Duman, Catharine H, Delpire, Eric, Picciotto, Marina, Wohleb, Eric S, Duman, Ronald S

“…A single subanesthetic dose of ketamine, an NMDA receptor (NMDAR) antagonist, produces rapid and sustained antidepressant actions in depressed patients,…”
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PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies by Bhatt, Shivani, Hillmer, Ansel T., Girgenti, Matthew J., Rusowicz, Aleksandra, Kapinos, Michael, Nabulsi, Nabeel, Huang, Yiyun, Matuskey, David, Angarita, Gustavo A., Esterlis, Irina, Davis, Margaret T., Southwick, Steven M., Friedman, Matthew J., Duman, Ronald S., Carson, Richard E., Krystal, John H., Pietrzak, Robert H., Cosgrove, Kelly P.

“…Despite well-known peripheral immune activation in posttraumatic stress disorder (PTSD), there are no studies of brain immunologic regulation in individuals…”
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Ketamine accelerates fear extinction via mTORC1 signaling by Girgenti, Matthew J, Ghosal, Sriparna, LoPresto, Dora, Taylor, Jane R, Duman, Ronald S

“…Abstract Impaired fear extinction contributes to the persistence of post-traumatic stress disorder (PTSD), and can be utilized for the study of novel…”
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Venus: An efficient virus infection detection and fusion site discovery method using single-cell and bulk RNA-seq data by Lee, Che Yu, Chen, Yuhang, Duan, Ziheng, Xu, Min, Girgenti, Matthew J, Xu, Ke, Gerstein, Mark, Zhang, Jing

“…Early and accurate detection of viruses in clinical and environmental samples is essential for effective public healthcare, treatment, and therapeutics. While…”
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Tuning parameters for polygenic risk score methods using GWAS summary statistics from training data by Jiang, Wei, Chen, Ling, Girgenti, Matthew J., Zhao, Hongyu

“…Various polygenic risk scores (PRS) methods have been proposed to combine the estimated effects of single nucleotide polymorphisms (SNPs) to predict genetic…”
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Transcriptome Alterations in Posttraumatic Stress Disorder by Girgenti, Matthew J., Duman, Ronald S.

“…Posttraumatic stress disorder (PTSD) is a debilitating psychiatric disorder with a lifetime prevalence of nearly 8% in the general population. While the…”
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Activity-Dependent Brain-Derived Neurotrophic Factor Release Is Required for the Rapid Antidepressant Actions of Scopolamine by Ghosal, Sriparna, Bang, Eunyoung, Yue, Wenzhu, Hare, Brendan D., Lepack, Ashley E., Girgenti, Matthew J., Duman, Ronald S.

“…Brain-derived neurotrophic factor (BDNF) plays a key role in the pathophysiology and treatment of depression. Recent clinical studies demonstrate that…”
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The Dyslexia-Associated Gene Dcdc2 Is Required for Spike-Timing Precision in Mouse Neocortex by Che, Alicia, Girgenti, Matthew J, LoTurco, Joseph

“…Background Variants in dyslexia-associated genes, including DCDC2 , have been linked to altered neocortical activation, suggesting that dyslexia associated…”
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Ketamine rapidly reverses stress-induced impairments in GABAergic transmission in the prefrontal cortex in male rodents by Ghosal, Sriparna, Duman, Catharine H., Liu, Rong-Jian, Wu, Min, Terwilliger, Rosemarie, Girgenti, Matthew J., Wohleb, Eric, Fogaca, Manoela V., Teichman, Emily M., Hare, Brendan, Duman, Ronald S.

“…Dysfunction of medial prefrontal cortex (mPFC) in association with imbalance of inhibitory and excitatory neurotransmission has been implicated in depression…”
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iHerd: an integrative hierarchical graph representation learning framework to quantify network changes and prioritize risk genes in disease by Duan, Ziheng, Dai, Yi, Hwang, Ahyeon, Lee, Cheyu, Xie, Kaichi, Xiao, Chutong, Xu, Min, Girgenti, Matthew J, Zhang, Jing

“…Different genes form complex networks within cells to carry out critical cellular functions, while network alterations in this process can potentially…”
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Altered metabotropic glutamate receptor 5 markers in PTSD: In vivo and postmortem evidence by Holmes, Sophie E., Girgenti, Matthew J., Davis, Margaret T., Pietrzak, Robert H., DellaGioia, Nicole, Nabulsi, Nabeel, Matuskey, David, Southwick, Steven, Duman, Ronald S., Carson, Richard E., Krystal, John H., Esterlis, Irina

“…Posttraumatic stress disorder (PTSD) is a prevalent and highly disabling disorder, but there is currently no targeted pharmacological treatment for it…”
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Molecular and cellular evolution of the primate dorsolateral prefrontal cortex by Ma, Shaojie, Skarica, Mario, Li, Qian, Xu, Chuan, Risgaard, Ryan D, Tebbenkamp, Andrew T N, Mato-Blanco, Xoel, Kovner, Rothem, Krsnik, Željka, de Martin, Xabier, Luria, Victor, Martí-Pérez, Xavier, Liang, Dan, Karger, Amir, Schmidt, Danielle K, Gomez-Sanchez, Zachary, Qi, Cai, Gobeske, Kevin T, Pochareddy, Sirisha, Debnath, Ashwin, Hottman, Cade J, Spurrier, Joshua, Teo, Leon, Boghdadi, Anthony G, Homman-Ludiye, Jihane, Ely, John J, Daadi, Etienne W, Mi, Da, Daadi, Marcel, Marín, Oscar, Hof, Patrick R, Rasin, Mladen-Roko, Bourne, James, Sherwood, Chet C, Santpere, Gabriel, Girgenti, Matthew J, Strittmatter, Stephen M, Sousa, André M M, Sestan, Nenad

“…The granular dorsolateral prefrontal cortex (dlPFC) is an evolutionary specialization of primates that is centrally involved in cognition. We assessed more…”
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Molecular and cellular studies of PTSD: Postmortem transcriptome analysis and novel therapeutic targets by Duman, Ronald S., Girgenti, Matthew J.

“…The neurobiology of fear memory and extinction has been the subject of extensive research efforts that have increased our understanding of the brain regions,…”
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Cortical Transcriptomic Alterations in Association With Appetitive Neuropeptides and Body Mass Index in Posttraumatic Stress Disorder by Stone, Lauren A, Girgenti, Matthew J, Wang, Jiawei, Ji, Dingjue, Zhao, Hongyu, Krystal, John H, Duman, Ronald S

“…Abstract Background The molecular pathology underlying posttraumatic stress disorder (PTSD) remains unclear mainly due to a lack of human PTSD postmortem brain…”
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ZNF804a regulates expression of the schizophrenia-associated genes PRSS16, COMT, PDE4B, and DRD2 by Girgenti, Matthew J, LoTurco, Joseph J, Maher, Brady J

“…ZNF804a was identified by a genome-wide association study (GWAS) in which a single nucleotide polymorphism (SNP rs1344706) in ZNF804a reached genome-wide…”
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Matthew J. Friedman, M.D., Ph.D. and His Legacy of Leadership in the Field of Post-traumatic Stress Disorder by Krystal, John H., Southwick, Steven M., Girgenti, Matthew J.

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