Search Results - "Girbig, Frank"

Aminopeptidase N (CD13) Is a Molecular Target of the Cholesterol Absorption Inhibitor Ezetimibe in the Enterocyte Brush Border Membrane by Kramer, Werner, Girbig, Frank, Corsiero, Daniel, Pfenninger, Anja, Frick, Wendelin, Jähne, Gerhard, Rhein, Matthias, Wendler, Wolfgang, Lottspeich, Friedrich, Hochleitner, Elisabeth O., Orsó, Evelyn, Schmitz, Gerd

“…Intestinal cholesterol absorption is an important regulator of serum cholesterol levels. Ezetimibe is a specific inhibitor of intestinal cholesterol absorption…”
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Substrate specificity of the ileal and the hepatic Na(+)/bile acid cotransporters of the rabbit. I. Transport studies with membrane vesicles and cell lines expressing the cloned transporters by Kramer, W, Stengelin, S, Baringhaus, K H, Enhsen, A, Heuer, H, Becker, W, Corsiero, D, Girbig, F, Noll, R, Weyland, C

“…The substrate specificity of the ileal and the hepatic Na(+)/bile acid cotransporters was determined using brush border membrane vesicles and CHO cell lines…”
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Identification of binding proteins for cholesterol absorption inhibitors as components of the intestinal cholesterol transporter by Kramer, Werner, Glombik, Heiner, Petry, Stephan, Heuer, Hubert, Schäfer, Hans-Ludwig, Wendler, Wolfgang, Corsiero, Daniel, Girbig, Frank, Weyland, Claudia

“…To identify protein components of the intestinal cholesterol transporter, rabbit small intestinal brush border membrane vesicles were submitted to…”
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Identification of a Ligand-binding Site in the Na+/Bile Acid Cotransporting Protein from Rabbit Ileum by Kramer, Werner, Girbig, Frank, Glombik, Heiner, Corsiero, Daniel, Stengelin, Siegfried, Weyland, Claudia

“…Reabsorption of bile acids occurs in the terminal ileum by a Na+-dependent transport system composed of several subunits of the ileal bile acid transporter…”
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Identification of the Bile Acid-binding Site of the Ileal Lipid-binding Protein by Photoaffinity Labeling, Matrix-assisted Laser Desorption Ionization-Mass Spectrometry, and NMR Structure by Kramer, Werner, Sauber, Klaus, Baringhaus, Karl-Heinz, Kurz, Michael, Stengelin, Siegfried, Lange, Gudrun, Corsiero, Daniel, Girbig, Frank, König, Waltraud, Weyland, Claudia

“…The ileal lipid-binding protein (ILBP) is the only physiologically relevant bile acid-binding protein in the cytosol of ileocytes. To identify the bile…”
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Characterization and chemical modification of the Na(+)-dependent bile-acid transport system in brush-border membrane vesicles from rabbit ileum by Kramer, W, Nicol, S B, Girbig, F, Gutjahr, U, Kowalewski, S, Fasold, H

“…The Na(+)-dependent uptake system for bile acids in the ileum from rabbit small intestine was characterized using brush-border membrane vesicles. The uptake of…”
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Rabbit small intestine does not contain an annexin II/caveolin 1 complex as a target for 2-azetidinone cholesterol absorption inhibitors by Kramer, Werner, Corsiero, Daniel, Girbig, Frank, Jähne, Gerhard

“…Intestinal cholesterol absorption is specifically inhibited by the 2-azetidinone cholesterol absorption inhibitor ezetimibe. Photoreactive ezetimibe analogues…”
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Intestinal cholesterol absorption: identification of different binding proteins for cholesterol and cholesterol absorption inhibitors in the enterocyte brush border membrane by Kramer, Werner, Girbig, Frank, Corsiero, Daniel, Burger, Katja, Fahrenholz, Falk, Jung, Christian, Müller, Günter

“…Absorption of cholesterol from the intestine is a central part of body cholesterol homeostasis. The molecular mechanisms of intestinal cholesterol absorption…”
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Synthesis of a biotin-tagged photoaffinity probe of 2-azetidinone cholesterol absorption inhibitors by Frick, Wendelin, Bauer-Schäfer, Andrea, Bauer, Jochen, Girbig, Frank, Corsiero, Daniel, Heuer, Hubert, Kramer, Werner

“…The design and synthesis of a biotin-tagged photoreactive analogue C-4 of the cholesterol absorption inhibitor Ezetimibe is described. Photoaffinity labeling…”
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Intestinal absorption of bile acids: paradoxical behaviour of the 14 kDa ileal lipid-binding protein in differential photoaffinity labelling by Kramer, W, Corsiero, D, Friedrich, M, Girbig, F, Stengelin, S, Weyland, C

“…Photoaffinity labelling of brush border membrane vesicles from rabbit ileum with radiolabelled 3,3-azo and 7,7-azo derivatives of taurocholate identified…”
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Synthesis of a biotin-tagged photo affinity probe of 2-azetidinone cholesterol absorption inhibitors by FRICK, Wendelin, BAUER-SCHÄFER, Andrea, BAUER, Jochen, GIRBIG, Frank, CORSIERO, Daniel, HEUER, Hubert, KRAMER, Werner

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Intestinal bile acid absorption. Na(+)-dependent bile acid transport activity in rabbit small intestine correlates with the coexpression of an integral 93-kDa and a peripheral 14-kDa bile acid-binding membrane protein along the duodenum-ileum axis by Kramer, W., Girbig, F., Gutjahr, U., Kowalewski, S., Jouvenal, K., Müller, G., Tripier, D., Wess, G.

“…The anatomical localization of the Na+/bile acid cotransport system from rabbit small intestine was determined using brush border membrane vesicles prepared…”
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Liver-specific drug targeting by coupling to bile acids by KRAMER, W, WESS, G, MÜLLNER, S, NECKERMANN, G, SCHULZ, S, PETZINGER, E, SCHUBERT, G, BICKEL, M, GIRBIG, F, GUTJAHR, U, KOWALEWSKI, S, BARINGHAUS, K.-H, ENHSEN, A, GLOMBIK, H

“…Bile acids are selectively taken up from portal blood into the liver by specific transport systems in the hepatocyte plasma membrane. Therefore, studies were…”
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Intestinal absorption of peptides by coupling to bile acids by KRAMER, W, WESS, G, ENHSEN, A, FALK, E, FRIEDRICH, M, GLOMBIK, H, HOFFMANN, A, PITTIUS, C, URMANN, M, NECKERMANN, G, SCHUBERT, G, FINK, J, GIRBIG, F, GUTJAHR, U, KOWALEWSKI, S, BARINGHAUS, K.-H, BÖGER, G

“…Poor intestinal absorption of peptides greatly limits their use as drugs for the treatment of chronic diseases. Since bile acids are efficiently absorbed by an…”
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Structural studies of the H+/oligopeptide transport system from rabbit small intestine by Kramer, Werner, Girbig, Frank, Bewersdorf, Ulrike, Kohlrautz, Simone, Weyland, Claudia

“…A 127-kDa protein was identified as a component of the H+/oligopeptide transport system in brush-border membrane vesicles from rabbit small intestine by…”
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Identification of protein components of the microsomal glucose 6-phosphate transporter by photoaffinity labelling by KRAMER, Werner, BURGER, Hans-Joerg, ARION, William J., CORSIERO, Daniel, GIRBIG, Frank, WEYLAND, Claudia, HEMMERLE, Horst, PETRY, Stefan, HABERMANN, Paul, HERLING, Andreas

“…The glucose-6-phosphatase system catalyses the terminal step of hepatic glucose production from both gluconeogenesis and glycogenolysis and is thus a key…”
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Identification of protein components of the microsomal glucose 6-phosphate transporter by photoaffinity labelling by Kramer, W, Burger, H J, Arion, W J, Corsiero, D, Girbig, F, Weyland, C, Hemmerle, H, Petry, S, Habermann, P, Herling, A

“…The glucose-6-phosphatase system catalyses the terminal step of hepatic glucose production from both gluconeogenesis and glycogenolysis and is thus a key…”
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Interaction of renin inhibitors with the intestinal uptake system for oligopeptides and beta-lactam antibiotics by Kramer, W, Girbig, F, Gutjahr, U, Kleemann, H W, Leipe, I, Urbach, H, Wagner, A

“…The interaction of two renin inhibitors, S 86,2033 and S 86,3390, with the uptake system for beta-lactam antibiotics and small peptides in the brush border…”
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Interaction of the orally active dianionic cephalosporin cefixime with the uptake system for oligopeptides and alpha-amino-beta-lactam antibiotics in rabbit small intestine by Kramer, W, Gutjahr, U, Kowalewski, S, Girbig, F

“…The uptake of two orally active beta-lactam antibiotics of different chemical structure, the zwitterionic alpha-aminocephalosporin cephalexin and the dianionic…”
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The molecular interaction of sulfonylureas with β-cell ATP-sensitive K +-channels by Kramer, Werner, Müller, Günter, Girbig, Frank, Gutjahr, Ulrike, Kowalewski, Simone, Hartz, Detlef, Summ, Hans-Dieter

“…The molecular interaction of glimepiride and glibenclamide with the β-cell sulfonylurea receptor was investigated by kinetic and steady state binding as well…”
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