Search Results - "Girardi, Enrico"

Effect of timing of implementation of containment measures on Covid-19 epidemic. The case of the first wave in Italy by Timelli, Laura, Girardi, Enrico

“…There is evidence that adoption of non-pharmaceutical containment measures (NPMs) may have had a major impact on Covid-19 epidemic dynamics, and mitigated its…”
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Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import by Girardi, Enrico, Agrimi, Gennaro, Goldmann, Ulrich, Fiume, Giuseppe, Lindinger, Sabrina, Sedlyarov, Vitaly, Srndic, Ismet, Gürtl, Bettina, Agerer, Benedikt, Kartnig, Felix, Scarcia, Pasquale, Di Noia, Maria Antonietta, Liñeiro, Eva, Rebsamen, Manuele, Wiedmer, Tabea, Bergthaler, Andreas, Palmieri, Luigi, Superti-Furga, Giulio

“…About a thousand genes in the human genome encode for membrane transporters. Among these, several solute carrier proteins (SLCs), representing the largest…”
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Immunological signature in human cases of monkeypox infection in 2022 outbreak: an observational study by Agrati, Chiara, Cossarizza, Andrea, Mazzotta, Valentina, Grassi, Germana, Casetti, Rita, De Biasi, Sara, Pinnetti, Carmela, Gili, Simona, Mondi, Annalisa, Cristofanelli, Flavia, Lo Tartaro, Domenico, Notari, Stefania, Maffongelli, Gaetano, Gagliardini, Roberta, Gibellini, Lara, Aguglia, Camilla, Lanini, Simone, D'Abramo, Alessandra, Matusali, Giulia, Fontana, Carla, Nicastri, Emanuele, Maggi, Fabrizio, Girardi, Enrico, Vaia, Francesco, Antinori, Andrea

“…An unprecedented global monkeypox outbreak started in May, 2022. No data are yet available about the dynamics of the immune response against monkeypox virus…”
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Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators by Pennemann, Friederike L., Mussabekova, Assel, Urban, Christian, Stukalov, Alexey, Andersen, Line Lykke, Grass, Vincent, Lavacca, Teresa Maria, Holze, Cathleen, Oubraham, Lila, Benamrouche, Yasmine, Girardi, Enrico, Boulos, Rasha E., Hartmann, Rune, Superti-Furga, Giulio, Habjan, Matthias, Imler, Jean-Luc, Meignin, Carine, Pichlmair, Andreas

“…The cell intrinsic antiviral response of multicellular organisms developed over millions of years and critically relies on the ability to sense and eliminate…”
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TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7–9 by Heinz, Leonhard X., Lee, JangEun, Kapoor, Utkarsh, Kartnig, Felix, Sedlyarov, Vitaly, Papakostas, Konstantinos, César-Razquin, Adrian, Essletzbichler, Patrick, Goldmann, Ulrich, Stefanovic, Adrijana, Bigenzahn, Johannes W., Scorzoni, Stefania, Pizzagalli, Mattia D., Bensimon, Ariel, Müller, André C., King, F. James, Li, Jun, Girardi, Enrico, Mbow, M. Lamine, Whitehurst, Charles E., Rebsamen, Manuele, Superti-Furga, Giulio

“…Toll-like receptors (TLRs) have a crucial role in the recognition of pathogens and initiation of immune responses 1 – 3 . Here we show that a previously…”
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A widespread role for SLC transmembrane transporters in resistance to cytotoxic drugs by Girardi, Enrico, César-Razquin, Adrián, Lindinger, Sabrina, Papakostas, Konstantinos, Konecka, Justyna, Hemmerich, Jennifer, Kickinger, Stefanie, Kartnig, Felix, Gürtl, Bettina, Klavins, Kristaps, Sedlyarov, Vitaly, Ingles-Prieto, Alvaro, Fiume, Giuseppe, Koren, Anna, Lardeau, Charles-Hugues, Kumaran Kandasamy, Richard, Kubicek, Stefan, Ecker, Gerhard F., Superti-Furga, Giulio

“…Solute carriers (SLCs) are the largest family of transmembrane transporters in humans and are major determinants of cellular metabolism. Several SLCs have been…”
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A substrate‐based ontology for human solute carriers by Meixner, Eva, Goldmann, Ulrich, Sedlyarov, Vitaly, Scorzoni, Stefania, Rebsamen, Manuele, Girardi, Enrico, Superti‐Furga, Giulio

“…Solute carriers (SLCs) are the largest family of transmembrane transporters in the human genome with more than 400 members. Despite the fact that SLCs mediate…”
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Safety and serum distribution of anti-SARS-CoV-2 monoclonal antibody MAD0004J08 after intramuscular injection by Lanini, Simone, Milleri, Stefano, Andreano, Emanuele, Nosari, Sarah, Paciello, Ida, Piccini, Giulia, Gentili, Alessandra, Phogat, Adhuna, Hyseni, Inesa, Leonardi, Margherita, Torelli, Alessandro, Montomoli, Emanuele, Paolini, Andrea, Frosini, Andrea, Antinori, Andrea, Nicastri, Emanuele, Girardi, Enrico, Plazzi, Maria Maddalena, Ippolito, Giuseppe, Vaia, Francesco, Della Cioppa, Giovanni, Rappuoli, Rino

“…The emerging threat represented by SARS-CoV-2 variants, demands the development of therapies for better clinical management of COVID-19. MAD0004J08 is a potent…”
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Risk assessment of tuberculosis in immunocompromised patients. A TBNET study by Sester, Martina, van Leth, Frank, Bruchfeld, Judith, Bumbacea, Dragos, Cirillo, Daniela M, Dilektasli, Asli Gorek, Domínguez, José, Duarte, Raquel, Ernst, Martin, Eyuboglu, Fusun Oner, Gerogianni, Irini, Girardi, Enrico, Goletti, Delia, Janssens, Jean-Paul, Julander, Inger, Lange, Berit, Latorre, Irene, Losi, Monica, Markova, Roumiana, Matteelli, Alberto, Milburn, Heather, Ravn, Pernille, Scholman, Theresia, Soccal, Paola M, Straub, Marina, Wagner, Dirk, Wolf, Timo, Yalcin, Aslihan, Lange, Christoph

“…In the absence of active tuberculosis, a positive tuberculin skin test (TST) or interferon-γ release assay (IGRA) result defines latent infection with…”
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COVID-19 disease-Temporal analyses of complete blood count parameters over course of illness, and relationship to patient demographics and management outcomes in survivors and non-survivors: A longitudinal descriptive cohort study by Lanini, Simone, Montaldo, Chiara, Nicastri, Emanuele, Vairo, Francesco, Agrati, Chiara, Petrosillo, Nicola, Scognamiglio, Paola, Antinori, Andrea, Puro, Vincenzo, Di Caro, Antonino, De Carli, Gabriella, Navarra, Assunta, Agresta, Alessandro, Cimaglia, Claudia, Palmieri, Fabrizio, D'Offizi, Gianpiero, Marchioni, Luisa, Kobinger, Gary Pignac, Maeurer, Markus, Girardi, Enrico, Capobianchi, Maria Rosaria, Zumla, Alimuddin, Locatelli, Franco, Ippolito, Giuseppe

“…Detailed temporal analyses of complete (full) blood count (CBC) parameters, their evolution and relationship to patient age, gender, co-morbidities and…”
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Recognition of lysophosphatidylcholine by type II NKT cells and protection from an inflammatory liver disease by Maricic, Igor, Girardi, Enrico, Zajonc, Dirk M, Kumar, Vipin

“…Lipids presented by the MHC class I-like molecule, CD1d, are recognized by NK T (NKT) cells, which can be broadly categorized into two subsets. The…”
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Autochthonous Dengue Fever in 2 Patients, Rome, Italy by Vita, Serena, Bordi, Licia, Sberna, Giuseppe, Caputi, Priscilla, Lapa, Daniele, Corpolongo, Angela, Mija, Cosmina, D'Abramo, Alessandra, Maggi, Fabrizio, Vairo, Francesco, Specchiarello, Eliana, Girardi, Enrico, Lalle, Eleonora, Nicastri, Emanuele

“…Since August 2023, outbreaks of dengue virus (DENV) infection have occurred in Italy. We report 2 autochthonous case-patients and their extended follow-up…”
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NANS-mediated synthesis of sialic acid is required for brain and skeletal development by van Karnebeek, Clara D M, Bonafé, Luisa, Wen, Xiao-Yan, Tarailo-Graovac, Maja, Balzano, Sara, Royer-Bertrand, Beryl, Ashikov, Angel, Garavelli, Livia, Mammi, Isabella, Turolla, Licia, Breen, Catherine, Donnai, Dian, Cormier-Daire, Valérie, Heron, Delphine, Nishimura, Gen, Uchikawa, Shinichi, Campos-Xavier, Belinda, Rossi, Antonio, Hennet, Thierry, Brand-Arzamendi, Koroboshka, Rozmus, Jacob, Harshman, Keith, Stevenson, Brian J, Girardi, Enrico, Superti-Furga, Giulio, Dewan, Tammie, Collingridge, Alissa, Halparin, Jessie, Ross, Colin J, Van Allen, Margot I, Rossi, Andrea, Engelke, Udo F, Kluijtmans, Leo A J, van der Heeft, Ed, Renkema, Herma, de Brouwer, Arjan, Huijben, Karin, Zijlstra, Fokje, Heise, Torben, Boltje, Thomas, Wasserman, Wyeth W, Rivolta, Carlo, Unger, Sheila, Lefeber, Dirk J, Wevers, Ron A, Superti-Furga, Andrea

“…Andrea Superti-Furga, Ron Wevers, Clara van Karnebeek, Luisa Bonafé and colleagues identify mutations in NANS , which encodes the sialic acid synthase, in nine…”
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Role of Direct Sexual Contact in Human Transmission of Monkeypox Virus, Italy by Sberna, Giuseppe, Rozera, Gabriella, Minosse, Claudia, Bordi, Licia, Mazzotta, Valentina, D'Abramo, Alessandra, Girardi, Enrico, Antinori, Andrea, Maggi, Fabrizio, Lalle, Eleonora

“…The 2022 global mpox outbreak was driven by human-to-human transmission, but modes of transmission by sexual relationship versus sexual contact remain unclear…”
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Rapid Determination of SARS-CoV-2 Integrity and Infectivity by Using Propidium Monoazide Coupled with Digital Droplet PCR by Sberna, Giuseppe, Mija, Cosmina, Lalle, Eleonora, Rozera, Gabriella, Matusali, Giulia, Carletti, Fabrizio, Girardi, Enrico, Maggi, Fabrizio

“…SARS-CoV-2 is a highly infectious virus responsible for the COVID-19 pandemic. Therefore, it is important to assess the risk of SARS-CoV-2 infection,…”
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The Bicarbonate Transporter SLC4A7 Plays a Key Role in Macrophage Phagosome Acidification by Sedlyarov, Vitaly, Eichner, Ruth, Girardi, Enrico, Essletzbichler, Patrick, Goldmann, Ulrich, Nunes-Hasler, Paula, Srndic, Ismet, Moskovskich, Anna, Heinz, Leonhard X., Kartnig, Felix, Bigenzahn, Johannes W., Rebsamen, Manuele, Kovarik, Pavel, Demaurex, Nicolas, Superti-Furga, Giulio

“…Macrophages represent the first line of immune defense against pathogens, and phagosome acidification is a necessary step in pathogen clearance. Here, we…”
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Association of COVID-19 case fatality rate with disease burden: an ecological analysis in Italy during the first wave by Timelli, Laura, Liuzzi, Giuseppina, Cannavacciuolo, Alessandro, Petrosillo, Nicola, Puro, Vincenzo, Girardi, Enrico

“…•The high burden of COVID-19 may have contributed to an increased disease fatality [Au?3].•The association of the case fatality rate with the cumulative…”
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Projections of non-communicable disease and health care costs among HIV-positive persons in Italy and the U.S.A.: A modelling study by Smit, Mikaela, Cassidy, Rachel, Cozzi-Lepri, Alessandro, Quiros-Roldan, Eugenia, Girardi, Enrico, Mammone, Alessia, Antinori, Andrea, Saracino, Annalisa, Bai, Francesca, Rusconi, Stefano, Magnani, Giacomo, Castelli, Francesco, Hsue, Priscilla, d'Arminio Monforte, Antonella, Hallett, Timothy B

“…Country-specific forecasts of the growing non-communicable disease (NCD) burden in ageing HIV-positive patients will be key to guide future HIV policies. We…”
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The possible effect of sociobehavioral factors and public health actions on the mpox epidemic slowdown by Vairo, Francesco, Leone, Sara, Mazzotta, Valentina, Piselli, Pierluca, De Carli, Gabriella, Lanini, Simone, Maggi, Fabrizio, Nicastri, Emanuele, Gagliardini, Roberta, Vita, Serena, Siddu, Andrea, Rezza, Giovanni, Barca, Alessandra, Vaia, Francesco, Antinori, Andrea, Girardi, Enrico

“…•Lazio region mpox prevention strategies included social and public health measures.•The vaccination campaign was an opportunity to inform those at risk of…”
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Putting in harm to cure: Drug related adverse events do not affect outcome of patients receiving treatment for multidrug-resistant Tuberculosis. Experience from a tertiary hospital in Italy by Gualano, Gina, Mencarini, Paola, Musso, Maria, Mosti, Silvia, Santangelo, Laura, Murachelli, Silvia, Cannas, Angela, Di Caro, Antonino, Navarra, Assunta, Goletti, Delia, Girardi, Enrico, Palmieri, Fabrizio

“…Treatment of multi-drug resistant Tuberculosis (MDR-TB) is challenging because it mostly relies on drugs with lower efficacy and greater toxicity than those…”
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