Search Results - "Giraldo, Jesús"

Structural Assessment of Agonist Efficacy in the μ‑Opioid Receptor: Morphine and Fentanyl Elicit Different Activation Patterns by Ricarte, Adrián, Dalton, James A. R, Giraldo, Jesús

“…Over the past two decades, the opioid epidemic in the United States and Canada has evidenced the need for a better understanding of the molecular mechanisms of…”
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Revealing the Mechanism of Agonist-Mediated Cannabinoid Receptor 1 (CB1) Activation and Phospholipid-Mediated Allosteric Modulation by Díaz, Óscar, Dalton, James A. R, Giraldo, Jesús

“…Cannabinoid receptor 1 (CB1) mediates the functional responses of Δ9-tetrahydrocannabinol. Although progress has been made in understanding cannabinoid binding…”
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Pharmacological evidence for a metabotropic glutamate receptor heterodimer in neuronal cells by Moreno Delgado, David, Møller, Thor C, Ster, Jeanne, Giraldo, Jesús, Maurel, Damien, Rovira, Xavier, Scholler, Pauline, Zwier, Jurriaan M, Perroy, Julie, Durroux, Thierry, Trinquet, Eric, Prezeau, Laurent, Rondard, Philippe, Pin, Jean-Philippe

“…Metabotropic glutamate receptors (mGluRs) are mandatory dimers playing important roles in regulating CNS function. Although assumed to form exclusive…”
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Oligomerization in health and disease: from enzymes to G protein-coupled receptors by Giraldo, Jesus, Ciruela, Francisco

“…Oligomerization in Health and Disease: From Enzymes to G Protein-Coupled Receptors, Volume 169 in the Progress in Molecular Biology and Translational Science…”
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Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer by Liu, Junke, Zhang, Zongyong, Moreno-Delgado, David, Dalton, James Ar, Rovira, Xavier, Trapero, Ana, Goudet, Cyril, Llebaria, Amadeu, Giraldo, Jesús, Yuan, Qilin, Rondard, Philippe, Huang, Siluo, Liu, Jianfeng, Pin, Jean-Philippe

“…GPCRs play critical roles in cell communication. Although GPCRs can form heteromers, their role in signaling remains elusive. Here we used rat metabotropic…”
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Remote local photoactivation of morphine produces analgesia without opioid‐related adverse effects by López‐Cano, Marc, Font, Joan, Aso, Ester, Sahlholm, Kristoffer, Cabré, Gisela, Giraldo, Jesús, De Koninck, Yves, Hernando, Jordi, Llebaria, Amadeu, Fernández‐Dueñas, Víctor, Ciruela, Francisco

“…Background and Purpose Opioid‐based drugs are the gold standard medicines for pain relief. However, tolerance and several side effects (i.e. constipation and…”
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Evaluating Allosteric Perturbations in Cannabinoid Receptor 1 by In Silico Single-Point Mutation by Díaz, Oscar, Renault, Pedro, Giraldo, Jesús

“…Cannabinoid receptor 1 (CB1) is a promising drug target involved in many physiological processes. Using atomistic molecular dynamics (MD) simulations, we…”
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Insights into adenosine A2A receptor activation through cooperative modulation of agonist and allosteric lipid interactions by Bruzzese, Agustín, Dalton, James A R, Giraldo, Jesús

“…The activation process of G protein-coupled receptors (GPCRs) has been extensively studied, both experimentally and computationally. In particular, Molecular…”
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Selective Protonation of Acidic Residues Triggers Opsin Activation by Lans, Isaias, Dalton, James A. R, Giraldo, Jesús

“…Rhodopsin, the visual pigment in the retina, is a Class A G protein-coupled receptor (GPCR) covalently bound to retinal chromophore. In dark conditions,…”
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Distinct Dopamine D₂ Receptor Antagonists Differentially Impact D₂ Receptor Oligomerization by Wouters, Elise, Marín, Adrián Ricarte, Dalton, James Andrew Rupert, Giraldo, Jesús, Stove, Christophe

“…Dopamine D₂ receptors (D₂R) are known to form transient homodimer complexes, of which the increased formation has already been associated with development of…”
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ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system by Birgül Iyison, Necla, Abboud, Clauda, Abboud, Dayana, Abdulrahman, Abdulrasheed O, Bondar, Ana-Nicoleta, Dam, Julie, Georgoussi, Zafiroula, Giraldo, Jesús, Horvat, Anemari, Karoussiotis, Christos, Paz-Castro, Alba, Scarpa, Miriam, Schihada, Hannes, Scholz, Nicole, Güvenc Tuna, Bilge, Vardjan, Nina

“…G protein-coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals…”
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Illuminating Phenylazopyridines To Photoswitch Metabotropic Glutamate Receptors: From the Flask to the Animals by Gómez-Santacana, Xavier, Pittolo, Silvia, Rovira, Xavier, Lopez, Marc, Zussy, Charleine, Dalton, James A. R, Faucherre, Adèle, Jopling, Chris, Pin, Jean-Philippe, Ciruela, Francisco, Goudet, Cyril, Giraldo, Jesús, Gorostiza, Pau, Llebaria, Amadeu

“…Phenylazopyridines are photoisomerizable compounds with high potential to control biological functions with light. We have obtained a series of…”
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Computational Analysis of Negative and Positive Allosteric Modulator Binding and Function in Metabotropic Glutamate Receptor 5 (In)Activation by Dalton, James A. R, Gómez-Santacana, Xavier, Llebaria, Amadeu, Giraldo, Jesús

“…Metabotropic glutamate receptors (mGluRs) are high-profile G-protein coupled receptors drug targets because of their involvement in several neurological…”
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Synthesis toward Bivalent Ligands for the Dopamine D2 and Metabotropic Glutamate 5 Receptors by Qian, Mingcheng, Wouters, Elise, Dalton, James A. R, Risseeuw, Martijn D. P, Crans, René A. J, Stove, Christophe, Giraldo, Jesús, Van Craenenbroeck, Kathleen, Van Calenbergh, Serge

“…In this study, we designed and synthesized heterobivalent ligands targeting heteromers consisting of the metabotropic glutamate 5 receptor (mGluR5) and the…”
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Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator by Font, Joan, López-Cano, Marc, Notartomaso, Serena, Scarselli, Pamela, Di Pietro, Paola, Bresolí-Obach, Roger, Battaglia, Giuseppe, Malhaire, Fanny, Rovira, Xavier, Catena, Juanlo, Giraldo, Jesús, Pin, Jean-Philippe, Fernández-Dueñas, Víctor, Goudet, Cyril, Nonell, Santi, Nicoletti, Ferdinando, Llebaria, Amadeu, Ciruela, Francisco

“…Light-operated drugs constitute a major target in drug discovery, since they may provide spatiotemporal resolution for the treatment of complex diseases (i.e…”
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Characterization of the Calcium-mediated Response to Alkaline Stress in Saccharomyces cerevisiae by Viladevall, Laia, Serrano, Raquel, Ruiz, Amparo, Domenech, Gema, Giraldo, Jesús, Barceló, Anna, Ariño, Joaquín

“…Exposure of the yeast Saccharomyces cerevisiae to alkaline stress resulted in adaptive changes that involved remodeling the gene expression. Recent evidence…”
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Follow-Up Genotoxic Study: Chromosome Damage Two and Six Years after Exposure to the Prestige Oil Spill by Hildur, Kristin, Templado, Cristina, Zock, Jan-Paul, Giraldo, Jesús, Pozo-Rodríguez, Francisco, Frances, Alexandra, Monyarch, Gemma, Rodríguez-Trigo, Gema, Rodriguez-Rodriguez, Emma, Souto, Ana, Gómez, Federico P, Antó, Josep M, Barberà, Joan Albert, Fuster, Carme

“…The north-west coast of Spain was heavily contaminated by the Prestige oil spill, in 2002. Individuals who participated in the clean-up tasks showed increased…”
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Persistence of Breakage in Specific Chromosome Bands 6 Years after Acute Exposure to Oil by Francés, Alexandra, Hildur, Kristin, Barberà, Joan Albert, Rodríguez-Trigo, Gema, Zock, Jan-Paul, Giraldo, Jesús, Monyarch, Gemma, Rodriguez-Rodriguez, Emma, de Castro Reis, Fernanda, Souto, Ana, Gómez, Federico P, Pozo-Rodríguez, Francisco, Templado, Cristina, Fuster, Carme

“…The identification of breakpoints involved in chromosomal damage could help to detect genes involved in genetic disorders, most notably cancer. Until now, only…”
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Genomewide Screen for Tolerance to Cationic Drugs Reveals Genes Important for Potassium Homeostasis in Saccharomyces cerevisiae by Barreto, Lina, Canadell, David, Petrezsélyová, Silvia, Navarrete, Clara, Marešová, Lydie, Peréz-Valle, Jorge, Herrera, Rito, Olier, Iván, Giraldo, Jesús, Sychrová, Hana, Yenush, Lynne, Ramos, José, Ariño, Joaquín

“…Potassium homeostasis is crucial for living cells. In the yeast Saccharomyces cerevisiae, the uptake of potassium is driven by the electrochemical gradient…”
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Shining Light on an mGlu5 Photoswitchable NAM: A Theoretical Perspective by Dalton, James A R, Lans, Isaias, Rovira, Xavier, Malhaire, Fanny, Gómez-Santacana, Xavier, Pittolo, Silvia, Gorostiza, Pau, Llebaria, Amadeu, Goudet, Cyril, Pin, Jean-Philippe, Giraldo, Jesús

“…Metabotropic glutamate receptors (mGluRs) are important drug targets because of their involvement in several neurological diseases. Among mGluRs, mGlu5 is a…”
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