Search Results - "Giovinazzi, Serena"

Antagomir-17-5p abolishes the growth of therapy-resistant neuroblastoma through p21 and BIM by Fontana, Laura, Fiori, Micol E, Albini, Sonia, Cifaldi, Loredana, Giovinazzi, Serena, Forloni, Matteo, Boldrini, Renata, Donfrancesco, Alberto, Federici, Valentina, Giacomini, Patrizio, Peschle, Cesare, Fruci, Doriana

“…We identified a key oncogenic pathway underlying neuroblastoma progression: specifically, MYCN, expressed at elevated level, transactivates the miRNA 17-5p-92…”
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CENP-B protects centromere chromatin integrity by facilitating histone deposition via the H3.3-specific chaperone Daxx by Morozov, Viacheslav M, Giovinazzi, Serena, Ishov, Alexander M

“…The main chromatin unit, the nucleosome, can be modulated by the incorporation of histone variants that, in combination with posttranslational histones…”
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Approach to discover T- and B-cell antigens of intracellular pathogens applied to the design of Chlamydia trachomatis vaccines by Finco, Oretta, Frigimelica, Elisabetta, Buricchi, Francesca, Petracca, Roberto, Galli, Giuliano, Faenzi, Elisa, Meoni, Eva, Bonci, Alessandra, Agnusdei, Mauro, Nardelli, Filomena, Bartolini, Erika, Scarselli, Maria, Caproni, Elena, Laera, Donatello, Zedda, Luisanna, Skibinski, David, Giovinazzi, Serena, Bastone, Riccardo, Ianni, Elvira, Cevenini, Roberto, Grandi, Guido, Grifantini, Renata

“…Natural immunity against obligate and/or facultative intracellular pathogens is usually mediated by both humoral and cellular immunity. The identification of…”
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Mechanism of human Hb switching: a possible role of the kit receptor/miR 221-222 complex by GABBIANELLI, Marco, TESTA, Ugo, BONANNO, Giuseppina, MASSA, Adriana, CROCE, Carlo M, FONTANA, Laura, PESCHLE, Cesare, MORSILLI, Ornelia, PELOSI, Elvira, SAULLE, Ernestina, PETRUCCI, Eleonora, CASTELLI, Germana, GIOVINAZZI, Serena, MARIANI, Gualtiero, FIORI, Micol E

“…The human hemoglobin switch (HbF-->HbA) takes place in the peri/post-natal period. In adult life, however, the residual HbF (<1%) may be partially reactivated…”
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CT043, a Protective Antigen That Induces a CD4⁺ Th1 Response during Chlamydia trachomatis Infection in Mice and Humans by Meoni, Eva, Faenzi, Elisa, Frigimelica, Elisabetta, Zedda, Luisanna, Skibinski, David, Giovinazzi, Serena, Bonci, Alessandra, Petracca, Roberto, Bartolini, Erika, Galli, Giuliano, Agnusdei, Mauro, Nardelli, Filomena, Buricchi, Francesca, Norais, Nathalie, Ferlenghi, Ilaria, Donati, Manuela, Cevenini, Roberto, Finco, Oretta, Grandi, Guido, Grifantini, Renata

“…Despite several decades of intensive studies, no vaccines against Chlamydia trachomatis, an intracellular pathogen causing serious ocular and urogenital…”
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Daxx is a predominately nuclear protein that does not translocate to the cytoplasm in response to cell stress by Lindsay, Cory R., Giovinazzi, Serena, Ishov, Alexander M.

“…The intracellular translocation of Daxx to the cytoplasm is a phenomenon often attributed to cells undergoing stress, opposite to predominant nuclear…”
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Characterization of a novel Neisseria meningitidis Fur and iron‐regulated operon required for protection from oxidative stress: utility of DNA microarray in the assignment of the biological role of hypothetical genes by Grifantini, Renata, Frigimelica, Elisabetta, Delany, Isabel, Bartolini, Erika, Giovinazzi, Serena, Balloni, Sergio, Agarwal, Sarika, Galli, Giuliano, Genco, Caroline, Grandi, Guido

“…Summary We have previously shown that in the human pathogen Neisseria meningitidis group B (MenB) more than 200 genes are regulated in response to growth with…”
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Zika Virus Infection Induces DNA Damage Response in Human Neural Progenitors That Enhances Viral Replication by Hammack, Christy, Ogden, Sarah C, Madden, Jr, Joseph C, Medina, Angelica, Xu, Chongchong, Phillips, Ernest, Son, Yuna, Cone, Allaura, Giovinazzi, Serena, Didier, Ruth A, Gilbert, David M, Song, Hongjun, Ming, Guoli, Wen, Zhexing, Brinton, Margo A, Gunjan, Akash, Tang, Hengli

“…Zika virus (ZIKV) infection attenuates the growth of human neural progenitor cells (hNPCs). As these hNPCs generate the cortical neurons during early brain…”
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Targeting mitotic exit with hyperthermia or APC/C inhibition to increase paclitaxel efficacy by Giovinazzi, Serena, Bellapu, Dhruv, Morozov, Viacheslav M, Ishov, Alexander M

“…Microtubule-poisoning drugs, such as Paclitaxel (or Taxol, PTX), are powerful and commonly used anti-neoplastic agents for the treatment of several…”
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Preparation of Cell Extracts by Cryogrinding in an Automated Freezer Mill by Phillips, Ernest O N, Giovinazzi, Serena, Menz, Sarah L, Son, Yuna, Gunjan, Akash

“…The ease of genetic manipulation and the strong evolutionary conservation of eukaryotic cellular machinery in the budding yeast Saccharomyces cerevisiae has…”
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Usp7 protects genomic stability by regulating Bub3 by Giovinazzi, Serena, Sirleto, Pietro, Aksenova, Vasilisa, Morozov, Viacheslav M, Zori, Roberto, Reinhold, William C, Ishov, Alexander M

“…USP7 (Ubiquitin Specific processing Protease-7) is a deubiquitinase which, over the past decade emerged as a critical regulator of cellular processes…”
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Abstract 573: USP7 and Daxx regulate mitosis progression and taxane sensitivity by affecting stability of Aurora A kinase by Giovinazzi, Serena, Morozov, Viacheslav M., Summers, Matthew K., Reinhold, William C., Ishov, Alexander M.

“…Abstract A large number of patients are resistant to taxane-based chemotherapy. Functional mitotic checkpoints are essential for taxane sensitivity. Thus,…”
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Abstract 2988: Regulation of mitosis and taxane response by Daxx by Giovinazzi, Serena, Lindsay, Cory, Morozov, Viacheslav, Han, Hyo, Ishov, Alexander

“…Abstract Current theories suggest that mitotic proteins are essential for cellular response to taxanes (paclitaxel and docetaxel), a widely-used family of…”
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Structural Characterization of the DAXX N-Terminal Helical Bundle Domain and Its Complex with Rassf1C by Escobar-Cabrera, Eric, Lau, Desmond K.W., Giovinazzi, Serena, Ishov, Alexander M., McIntosh, Lawrence P.

“…DAXX is a scaffold protein with diverse roles including transcription and cell cycle regulation. Using NMR spectroscopy, we demonstrate that the C-terminal…”
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Regulation of mitosis and taxane response by Daxx and Rassf1 by Giovinazzi, S, Lindsay, C R, Morozov, V M, Escobar-Cabrera, E, Summers, M K, Han, H S, McIntosh, L P, Ishov, A M

“…Current theories suggest that mitotic checkpoint proteins are essential for proper cellular response to taxanes, a widely used family of chemotherapeutic…”
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Role of FNR and FNR‐regulated, sugar fermentation genes in Neisseria meningitidis infection by Bartolini, Erika, Frigimelica, Elisabetta, Giovinazzi, Serena, Galli, Giuliano, Shaik, Yazdani, Genco, Caroline, Welsch, Jo Anne, Granoff, Dan M., Grandi, Guido, Grifantini, Renata

“…Summary While it is generally accepted that anaerobic metabolism is required during infection, supporting experimental data have only been described in a…”
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Daxx mitotic function plays a pivotal role in chemotherapy resistance and cancer progression by Giovinazzi, Serena

“…Breast cancer accounts yearly for 200,000 newly diagnosed American women and loss of 40.000 of them, representing the number one killer in middle-aged women…”
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