Search Results - "Giovannoni, Roberto"

The Role of Hydrogen Peroxide in Redox-Dependent Signaling: Homeostatic and Pathological Responses in Mammalian Cells by Di Marzo, Noemi, Chisci, Elisa, Giovannoni, Roberto

“…Hydrogen peroxide (H₂O₂) is an important metabolite involved in most of the redox metabolism reactions and processes of the cells. H₂O₂ is recognized as one of…”
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News on immune checkpoint inhibitors as immunotherapy strategies in adult and pediatric solid tumors by Melaiu, Ombretta, Lucarini, Valeria, Giovannoni, Roberto, Fruci, Doriana, Gemignani, Federica

“…Immune checkpoint inhibitors (ICIs) have shown unprecedented benefits in various adult cancers, and this success has prompted the exploration of ICI therapy…”
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Resveratrol Impairs Glioma Stem Cells Proliferation and Motility by Modulating the Wnt Signaling Pathway by Cilibrasi, Chiara, Riva, Gabriele, Romano, Gabriele, Cadamuro, Massimiliano, Bazzoni, Riccardo, Butta, Valentina, Paoletta, Laura, Dalprà, Leda, Strazzabosco, Mario, Lavitrano, Marialuisa, Giovannoni, Roberto, Bentivegna, Angela

“…Glioblastoma multiforme (GBM) is a grade IV astrocytoma and the most common form of malignant brain tumor in adults. GBM remains one of the most fatal and…”
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The Glioblastoma Microenvironment: Morphology, Metabolism, and Molecular Signature of Glial Dynamics to Discover Metabolic Rewiring Sequence by Virtuoso, Assunta, Giovannoni, Roberto, De Luca, Ciro, Gargano, Francesca, Cerasuolo, Michele, Maggio, Nicola, Lavitrano, Marialuisa, Papa, Michele

“…Different functional states determine glioblastoma (GBM) heterogeneity. Brain cancer cells coexist with the glial cells in a functional syncytium based on a…”
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Current Therapeutical Approaches Targeting Lipid Metabolism in NAFLD by Vitulo, Manuela, Gnodi, Elisa, Rosini, Giulia, Meneveri, Raffaella, Giovannoni, Roberto, Barisani, Donatella

“…Nonalcoholic fatty liver disease (NAFLD, including nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH)) is a high-prevalence disorder,…”
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CD73 Regulates Stemness and Epithelial-Mesenchymal Transition in Ovarian Cancer-Initiating Cells by Lupia, Michela, Angiolini, Francesca, Bertalot, Giovanni, Freddi, Stefano, Sachsenmeier, Kris F., Chisci, Elisa, Kutryb-Zajac, Barbara, Confalonieri, Stefano, Smolenski, Ryszard T., Giovannoni, Roberto, Colombo, Nicoletta, Bianchi, Fabrizio, Cavallaro, Ugo

“…Cancer-initiating cells (CICs) have been implicated in tumor development and aggressiveness. In ovarian carcinoma (OC), CICs drive tumor formation,…”
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DNAM-1 chimeric receptor-engineered NK cells: a new frontier for CAR-NK cell-based immunotherapy by Cifaldi, Loredana, Melaiu, Ombretta, Giovannoni, Roberto, Benvenuto, Monica, Focaccetti, Chiara, Nardozi, Daniela, Barillari, Giovanni, Bei, Roberto

“…DNAM-1 is a major NK cell activating receptor and, together with NKG2D and NCRs, by binding specific ligands, strongly contributes to mediating the killing of…”
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De Novo Genome Assembly at Chromosome-Scale of Hermetia illucens (Diptera Stratiomyidae) via PacBio and Omni-C Proximity Ligation Technology by Costagli, Simone, Abenaim, Linda, Rosini, Giulia, Conti, Barbara, Giovannoni, Roberto

“…is a species of great interest for numerous industrial applications. A high-quality reference genome is already available for . However, the worldwide…”
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Electrospun Fiber‐Based Tubular Structures as 3D Scaffolds to Generate In Vitro Models for Small Intestine by Zavagna, Lorenzo, Canelli, Eligio F., Azimi, Bahareh, Troisi, Fabiola, Scarpelli, Lorenzo, Macchi, Teresa, Gallone, Giuseppe, Labardi, Massimiliano, Giovannoni, Roberto, Milazzo, Mario, Danti, Serena

“…Recently, in vitro models emerge as valuable tools in biomedical research by enabling the investigation of complex physiological processes in a controlled…”
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Inhibition of GSK3B Bypass Drug Resistance of p53-Null Colon Carcinomas by Enabling Necroptosis in Response to Chemotherapy by GRASSILLI, Emanuela, NARLOCH, Robert, DONADA, Marisa, STANTA, Giorgio, HELIN, Kristian, LAVITRANO, Marialuisa, FEDERZONI, Elena, IANZANO, Leonarda, PISANO, Fabio, GIOVANNONI, Roberto, ROMANO, Gabriele, MASIERO, Laura, LEONE, Biagio Eugenio, BONIN, Serena

“…Evasion from chemotherapy-induced apoptosis due to p53 loss strongly contributes to drug resistance. Identification of specific targets for the treatment of…”
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Combining ERAP1 silencing and entinostat therapy to overcome resistance to cancer immunotherapy in neuroblastoma by Tempora, Patrizia, D'Amico, Silvia, Gragera, Paula, Damiani, Verena, Krol, Kamila, Scaldaferri, Valentina, Pandey, Kirti, Chung, Shanzou, Lucarini, Valeria, Giorda, Ezio, Scarsella, Marco, Volpe, Gabriele, Pezzullo, Marco, De Stefanis, Cristiano, D'Oria, Valentina, De Angelis, Lorenzo, Giovannoni, Roberto, De Ioris, Maria Antonietta, Melaiu, Ombretta, Purcell, Anthony W, Locatelli, Franco, Fruci, Doriana

“…Checkpoint immunotherapy unleashes tumor control by T cells, but it is undermined in non-immunogenic tumors, e.g. with low MHC class I expression and low…”
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p65BTK is a novel potential actionable target in KRAS-mutated/EGFR-wild type lung adenocarcinoma by Giordano, Federica, Vaira, Valentina, Cortinovis, Diego, Bonomo, Sara, Goedmakers, Joyce, Brena, Federica, Cialdella, Annamaria, Ianzano, Leonarda, Forno, Irene, Cerrito, Maria Grazia, Giovannoni, Roberto, Ferri, Gian Luca, Tasciotti, Ennio, Vicent, Silve, Damarco, Francesco, Bosari, Silvano, Lavitrano, Marialuisa, Grassilli, Emanuela

“…Lung cancer is still the main cause of cancer death worldwide despite the availability of targeted therapies and immune-checkpoint inhibitors combined with…”
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Endothelial Effects of Simultaneous Expression of Human HO-1, E5NT, and ENTPD1 in a Mouse by Mierzejewska, Paulina, Di Marzo, Noemi, Zabielska-Kaczorowska, Magdalena A, Walczak, Iga, Slominska, Ewa M, Lavitrano, Marialuisa, Giovannoni, Roberto, Kutryb-Zajac, Barbara, Smolenski, Ryszard T

“…The vascular endothelium is key target for immune and thrombotic responses that has to be controlled in successful xenotransplantation. Several genes were…”
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GSK3A is redundant with GSK3B in modulating drug resistance and chemotherapy-induced necroptosis by Grassilli, Emanuela, Ianzano, Leonarda, Bonomo, Sara, Missaglia, Carola, Cerrito, Maria Grazia, Giovannoni, Roberto, Masiero, Laura, Lavitrano, Marialuisa

“…Glycogen Synthase Kinase-3 alpha (GSK3A) and beta (GSK3B) isoforms are encoded by distinct genes, are 98% identical within their kinase domain and perform…”
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A Novel KCNJ2 Mutation Identified in an Autistic Proband Affects the Single Channel Properties of Kir2.1 by Binda, Anna, Rivolta, Ilaria, Villa, Chiara, Chisci, Elisa, Beghi, Massimiliano, Cornaggia, Cesare M, Giovannoni, Roberto, Combi, Romina

“…Inwardly rectifying potassium channels (Kir) have been historically associated to several cardiovascular disorders. In particular, loss-of-function mutations…”
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Rhabdomyosarcoma Cells Produce Their Own Extracellular Matrix With Minimal Involvement of Cancer-Associated Fibroblasts: A Preliminary Study by D'Agostino, Stefania, Tombolan, Lucia, Saggioro, Mattia, Frasson, Chiara, Rampazzo, Elena, Pellegrini, Stefania, Favaretto, Francesca, Biz, Carlo, Ruggieri, Pietro, Gamba, Piergiorgio, Bonvini, Paolo, Aveic, Sanja, Giovannoni, Roberto, Pozzobon, Michela

“…The interplay between neoplastic cells and surrounding extracellular matrix (ECM) is one of the determinant elements for cancer growth. The remodeling of the…”
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p65BTK Is a Novel Biomarker and Therapeutic Target in Solid Tumors by Grassilli, Emanuela, Cerrito, Maria Grazia, Bonomo, Sara, Giovannoni, Roberto, Conconi, Donatella, Lavitrano, Marialuisa

“…Bruton’s tyrosine kinase (BTK) is a non-receptor intracellular kinase playing a key role in the proliferation and survival of normal and malignant…”
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A functional biological network centered on XRCC3: a new possible marker of chemoradiotherapy resistance in rectal cancer patients by Agostini, Marco, Zangrando, Andrea, Pastrello, Chiara, D'Angelo, Edoardo, Romano, Gabriele, Giovannoni, Roberto, Giordan, Marco, Maretto, Isacco, Bedin, Chiara, Zanon, Carlo, Digito, Maura, Esposito, Giovanni, Mescoli, Claudia, Lavitrano, Marialuisa, Rizzolio, Flavio, Jurisica, Igor, Giordano, Antonio, Pucciarelli, Salvatore, Nitti, Donato

“…Preoperative chemoradiotherapy is widely used to improve local control of disease, sphincter preservation and to improve survival in patients with locally…”
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Platinum-Based Drugs and DNA Interactions Studied by Single-Molecule and Bulk Measurements by Salerno, Domenico, Beretta, Giovanni L., Zanchetta, Giuliano, Brioschi, Simone, Cristofalo, Matteo, Missana, Natalia, Nardo, Luca, Cassina, Valeria, Tempestini, Alessia, Giovannoni, Roberto, Cerrito, Maria Grazia, Zaffaroni, Nadia, Bellini, Tommaso, Mantegazza, Francesco

“…Platinum-containing molecules are widely used as anticancer drugs. These molecules exert cytotoxic effects by binding to DNA through various mechanisms. The…”
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CoCl2-Mimicked Endothelial Cell Hypoxia Induces Nucleotide Depletion and Functional Impairment That Is Reversed by Nucleotide Precursors by Kutryb-Zajac, Barbara, Kawecka, Ada, Braczko, Alicja, Franczak, Marika, Slominska, Ewa M., Giovannoni, Roberto, Smolenski, Ryszard T.

“…Chronic hypoxia drives vascular dysfunction by various mechanisms, including changes in mitochondrial respiration. Although endothelial cells (ECs) rely…”
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