Search Results - "Giovagnoni, Caterina"

Ceramide analog [18F]F-HPA-12 detects sphingolipid disbalance in the brain of Alzheimer’s disease transgenic mice by functioning as a metabolic probe by Crivelli, Simone M., van Kruining, Daan, Luo, Qian, Stevens, Jo A. A., Giovagnoni, Caterina, Paulus, Andreas, Bauwens, Matthias, Berkes, Dusan, de Vries, Helga E., Mulder, Monique T., Walter, Jochen, Waelkens, Etienne, Derua, Rita, Swinnen, Johannes V., Dehairs, Jonas, Mottaghy, Felix M., Losen, Mario, Bieberich, Erhard, Martinez-Martinez, Pilar

“…The metabolism of ceramides is deregulated in the brain of Alzheimer’s disease (AD) patients and is associated with apolipoprotein (APO) APOE4 and amyloid-β…”
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Function of ceramide transfer protein for biogenesis and sphingolipid composition of extracellular vesicles by Crivelli, Simone M., Giovagnoni, Caterina, Zhu, Zhihui, Tripathi, Priyanka, Elsherbini, Ahmed, Quadri, Zainuddin, Pu, Jian, Zhang, Liping, Ferko, Branislav, Berkes, Dusan, Spassieva, Stefka D., Martinez‐Martinez, Pilar, Bieberich, Erhard

“…The formation of extracellular vesicles (EVs) is induced by the sphingolipid ceramide. How this pathway is regulated is not entirely understood. Here, we…”
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FTY720 decreases ceramides levels in the brain and prevents memory impairments in a mouse model of familial Alzheimer’s disease expressing APOE4 by Crivelli, Simone M., Luo, Qian, Kruining, Daan van, Giovagnoni, Caterina, Mané-Damas, Marina, den Hoedt, Sandra, Berkes, Dusan, De Vries, Helga E., Mulder, Monique T., Walter, Jochen, Waelkens, Etienne, Derua, Rita, Swinnen, Johannes V., Dehairs, Jonas, Wijnands, Erwin P.M., Bieberich, Erhard, Losen, Mario, Martinez-Martinez, Pilar

“…The protection mediated by the bioactive sphingolipid sphingosine-1-phosphate (S1P) declines during Alzheimer’s disease (AD) progression, especially in…”
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CERTL reduces C16 ceramide, amyloid-β levels, and inflammation in a model of Alzheimer’s disease by Crivelli, Simone M., Luo, Qian, Stevens, Jo A.A., Giovagnoni, Caterina, van Kruining, Daan, Bode, Gerard, den Hoedt, Sandra, Hobo, Barbara, Scheithauer, Anna-Lena, Walter, Jochen, Mulder, Monique T., Exley, Christopher, Mold, Matthew, Mielke, Michelle M., De Vries, Helga E., Wouters, Kristiaan, van den Hove, Daniel L. A., Berkes, Dusan, Ledesma, María Dolores, Verhaagen, Joost, Losen, Mario, Bieberich, Erhard, Martinez-Martinez, Pilar

“…Abstract Background Dysregulation of ceramide and sphingomyelin levels have been suggested to contribute to the pathogenesis of Alzheimer’s disease (AD)…”
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Sphingolipids in Alzheimer's disease, how can we target them? by Crivelli, Simone M., Giovagnoni, Caterina, Visseren, Lars, Scheithauer, Anna-Lena, de Wit, Nienke, den Hoedt, Sandra, Losen, Mario, Mulder, Monique T., Walter, Jochen, de Vries, Helga E., Bieberich, Erhard, Martinez-Martinez, Pilar

“…Altered levels of sphingolipids and their metabolites in the brain, and the related downstream effects on neuronal homeostasis and the immune system, provide a…”
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Immunofluorescence Labeling of Lipid-Binding Proteins CERTs to Monitor Lipid Raft Dynamics by Giovagnoni, Caterina, Crivelli, Simone M, Losen, Mario, Martinez-Martinez, Pilar

“…Fluorescence microscopy is a powerful and widely used tool in molecular biology. Over the years, the discovery and development of lipid-binding fluorescent…”
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Altered sphingolipid function in Alzheimer's disease; a gene regulatory network approach by Giovagnoni, Caterina, Ali, Muhammad, Eijssen, Lars M.T., Maes, Richard, Choe, Kyonghwan, Mulder, Monique, Kleinjans, Jos, del Sol, Antonio, Glaab, Enrico, Mastroeni, Diego, Delvaux, Elaine, Coleman, Paul, Losen, Mario, Pishva, Ehsan, Martinez-Martinez, Pilar, van den Hove, Daniel L.A.

“…•This study addressed the role of sphingolipid (SL)-related genes in Alzheimer's disease (AD).•PTGIS, GBA, ITGB2 presented both DNA hydroxymethylation and…”
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The Effect of FTY720 on Sphingolipid Imbalance and Cognitive Decline in Aged EFAD Mice by Luo, Qian, Crivelli, Simone M, Zong, Shenghua, Giovagnoni, Caterina, van Kruining, Daan, Mané-Damas, Marina, den Hoedt, Sandra, Berkes, Dusan, De Vries, Helga E, Mulder, Monique T, Walter, Jochen, Waelkens, Etienne, Derua, Rita, Swinnen, Johannes V, Dehairs, Jonas, Losen, Mario, Martinez-Martinez, Pilar

“…During Alzheimer's disease (AD) progression, there is a decline in the bioactive sphingolipid sphingosine-1-phosphate (S1P). Previous research showed that…”
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CERTL reduces C16 ceramide, amyloid-[beta] levels, and inflammation in a model of Alzheimer's disease by Crivelli, Simone M, Stevens, Jo A.A, Walter, Jochen, Berkes, Dusan, van Kruining, Daan, Bode, Gerard, Ledesma, María Dolores, den Hoedt, Sandra, Exley, Christopher, Hobo, Barbara, Verhaagen, Joost, Giovagnoni, Caterina, Losen, Mario, Martinez-Martinez, Pilar, Mulder, Monique T, Wouters, Kristiaan, van den Hove, Daniel L. A, Mielke, Michelle M, Luo, Qian, Scheithauer, Anna-Lena, Bieberich, Erhard, Mold, Matthew, De Vries, Helga E

“…Background Dysregulation of ceramide and sphingomyelin levels have been suggested to contribute to the pathogenesis of Alzheimer's disease (AD). Ceramide…”
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CERT L reduces C16 ceramide, amyloid-β levels, and inflammation in a model of Alzheimer's disease by Crivelli, Simone M, Luo, Qian, Stevens, Jo A A, Giovagnoni, Caterina, van Kruining, Daan, Bode, Gerard, den Hoedt, Sandra, Hobo, Barbara, Scheithauer, Anna-Lena, Walter, Jochen, Mulder, Monique T, Exley, Christopher, Mold, Matthew, Mielke, Michelle M, De Vries, Helga E, Wouters, Kristiaan, van den Hove, Daniel L A, Berkes, Dusan, Ledesma, María Dolores, Verhaagen, Joost, Losen, Mario, Bieberich, Erhard, Martinez-Martinez, Pilar

“…Dysregulation of ceramide and sphingomyelin levels have been suggested to contribute to the pathogenesis of Alzheimer's disease (AD). Ceramide transfer…”
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