I-131 Postablation SPECT/CT Predicts Relapse of Papillary Thyroid Carcinoma more Accurately than Whole Body Scan

The aim of the study was to prospectively compare I-131 postablation Whole Body scan (WBS) and Single Photon Emission Computerized Tomography/Computerized Tomography (SPECT/CT) scan on thyroid cancer patients. Overall, 58 patients with papillary thyroid carcinoma were submitted to total thyroidectom...

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Bibliographic Details
Published in:	In vivo (Athens) Vol. 33; no. 6; pp. 2255 - 2263
Main Authors:	Malamitsi, Julia V, Koutsikos, John T, Giourgouli, Stamatia I, Zachaki, Sophia F, Pipikos, Theodoros A, Vlachou, Fani J, Prassopoulos, Vassilios K
Format:	Journal Article
Language:	English
Published:	Greece International Institute of Anticancer Research 01-11-2019
Subjects:	Adult Aged Aged, 80 and over Biomarkers Female Humans Iodine Radioisotopes Male Middle Aged Recurrence Sensitivity and Specificity Thyroid Cancer, Papillary - diagnosis Thyroid Cancer, Papillary - therapy Tomography, Emission-Computed, Single-Photon - methods Tomography, Emission-Computed, Single-Photon - standards Tomography, X-Ray Computed - methods Tomography, X-Ray Computed - standards Whole Body Imaging - methods Whole Body Imaging - standards whole body scan Papillary thyroid carcinoma SPECT/CT I-131 postablation scan
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Summary:	The aim of the study was to prospectively compare I-131 postablation Whole Body scan (WBS) and Single Photon Emission Computerized Tomography/Computerized Tomography (SPECT/CT) scan on thyroid cancer patients. Overall, 58 patients with papillary thyroid carcinoma were submitted to total thyroidectomy and I-131 remnant ablation. Post-ablation WBS and SPECT/CT scans performed on the same day were compared. Results of SPECT/CT were confirmed by neck and upper mediastinum ultrasound scan and on specific cases by a fully diagnostic CT scan, other tests and definitive histology acting as the gold standard. A total of 36/58 patients were followed-up for 5 years to detect relapse. Mac Nemar Chi square and Fisher's exact tests disclosed statistically significant differences between WBS and SPECT/CT scan, concerning cervical lymphadenopathy detection (p=0.031) and relapse prediction by NM stage (p=0.033), respectively; SPECT/CT was more accurate in both comparisons. In papillary thyroid carcinoma I-131 post-ablation SPECT/CT scan detects cervical lymphadenopathy and predicts relapse by NM stage more accurately than WBS.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0258-851X 1791-7549
DOI:	10.21873/invivo.11731