Impact of Ultra High‐risk Genetics on Real‐world Outcomes of Transplant‐eligible Multiple Myeloma Patients

Refined prediction of early relapse following standard‐of‐care (SoC) autologous stem cell transplant (ASCT) in newly diagnosed multiple myeloma (NDMM) could inform real‐world risk‐stratified post‐ASCT strategies. We investigated the impact of double hit genetics (≥2 adverse markers: t(4;14), t(14;16...

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Bibliographic Details
Published in:	HemaSphere Vol. 7; no. 2; pp. e831 - n/a
Main Authors:	Panopoulou, Aikaterini, Easdale, Sandra, Ethell, Mark, Nicholson, Emma, Potter, Mike, Giotas, Asterios, Woods, Helena, Thornton, Tracy, Pawlyn, Charlotte, Boyd, Kevin D., Kaiser, Martin F.
Format:	Journal Article
Language:	English
Published:	Philadelphia, PA Lippincott Williams & Wilkins 01-02-2023 Wiley
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Summary:	Refined prediction of early relapse following standard‐of‐care (SoC) autologous stem cell transplant (ASCT) in newly diagnosed multiple myeloma (NDMM) could inform real‐world risk‐stratified post‐ASCT strategies. We investigated the impact of double hit genetics (≥2 adverse markers: t(4;14), t(14;16), t(14;20), gain(1q), del(17p)) on outcome in 139 NDMM patients who underwent SoC ASCT between January 2014 and October 2019 at our center. Double hit genetics were associated with a significantly shortened progression‐free survival (hazard ratio [HR] = 4.27, P < 0.001) and overall survival (HR = 4.01, P = 0.03), and characterized most early relapses. Our results support the real‐world utility of extended genetic profiling for improved risk prediction in NDMM.
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ISSN:	2572-9241 2572-9241
DOI:	10.1097/HS9.0000000000000831