Search Results - "Giorgetti, Belinda"
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The effect of late-life environmental enrichment on stress and anxiety: The role of sex and age-related differences in coping with aversive stimuli
Published in Heliyon (15-06-2024)“…Anxiety significantly diminishes the quality of life in older adults, and the drugs used for its treatment often come with risky side effects…”
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Sensibility and Specificity of the VitaPCR™ SARS-CoV-2 Assay for the Rapid Diagnosis of COVID-19 in Older Adults in the Emergency Department
Published in Viruses (09-01-2023)“…(1) Background: During the COVID-19 pandemic, rapid and reliable diagnostic tools are needed for detecting SARS-CoV-2 infection in urgent cases at admission to…”
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Platelets in Alzheimer's disease-associated cellular senescence and inflammation
Published in Current pharmaceutical design (01-03-2013)“…Alzheimer's disease (AD) is a complex degenerative disorder of the brain, associated with a progressive cognitive decline. Age is the main risk factor with…”
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Chronic Aluminum Administration to Old Rats Results in Increased Levels of Brain Metal Ions and Enlarged Hippocampal Mossy Fibers
Published in Annals of the New York Academy of Sciences (01-06-2004)“…: The effect of chronic aluminium administration (2 g/L/6 months) was investigated in the central nervous system (CNS) of old rats. The content of Al3+, Cu2+,…”
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A Ketogenic Diet Increases Succinic Dehydrogenase Activity in Aging Cardiomyocytes
Published in Annals of the New York Academy of Sciences (01-08-2009)“…Impairment of energy metabolism and an increase of reactive oxygen species (ROS) production seem to play a major role in age‐related apoptotic loss of…”
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Convergence between brain aging and Alzheimer’s disease: focus on mitochondria
Published in Mechanisms of ageing and development (01-12-2024)“…Alzheimer's disease (AD) accounts for the majority of dementia cases, with aging being the primary risk factor for developing this neurodegenerative condition…”
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Neuronal Death versus Synaptic Pathology in Alzheimer's Disease
Published in Annals of the New York Academy of Sciences (01-12-2003)“…: Neuron and synapse numeric densities as well as the average size and surface density of the synaptic junctional areas were measured in the hippocampus and…”
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Increased Mitochondrial and Nuclear Gene Expression of Cytochrome Oxidase Subunits I and IV in Neuronal Aging
Published in Annals of the New York Academy of Sciences (01-12-2004)“…: To assess the role of mitochondrial metabolic competence (MMC) in neuronal aging, quantitative immunohistochemistry of cytochrome oxidase (COX) subunits I…”
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Generation and Characterization of the First Murine Model of Alzheimer's Disease with Mutated AβPP Inserted in a BALB/c Background (C.B6/J-APPswe)
Published in Journal of Alzheimer's disease (13-06-2023)“…Numerous mouse models of Alzheimer's disease (AD) are available, but all suffer from certain limitations, thus prompting further attempts. To date, no one…”
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effect of astaxanthin on the aging rat brain: gender‐related differences in modulating inflammation
Published in Journal of the science of food and agriculture (30-01-2016)“…BACKGROUND: Astaxanthin (Ax) is a ketocarotenoid of the xanthophyll family with activities such as antioxidation, preservation of the integrity of cell…”
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Early selective vulnerability of synapses and synaptic mitochondria in the hippocampal CA1 region of the Tg2576 mouse model of Alzheimer's disease
Published in Journal of Alzheimer's disease (01-01-2013)“…Increasing experimental evidence indicates that synaptic alterations play a key role in cognitive decline in Alzheimer's disease (AD). Functional and…”
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Association of Inflammatory Mediators with Mitochondrial DNA Variants in Geriatric COVID-19 Patients
Published in Aging and disease (09-02-2024)“…COVID-19 remains a serious concern for elderly individuals with underlying comorbidities. SARS-CoV-2 can target and damage mitochondria, potentially leading to…”
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Diagnostic performance of new and classic CSF biomarkers in age-related dementias
Published in Aging (Albany, NY.) (27-04-2019)“…The identification of diagnostic-prognostic biomarkers of dementia has become a global priority due to the prevalence of neurodegenerative diseases in aging…”
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The effect of astaxanthin on the aging rat brain: gender-related differences in modulating inflammation
Published in Journal of the science of food and agriculture (01-09-2016)Get full text
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The effect of astaxanthin on the aging rat brain: gender-related differences in modulating inflammation: Erratum
Published in Journal of the science of food and agriculture (01-09-2016)Get full text
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Peripheral inflammatory biomarkers of Alzheimer’s disease: the role of platelets
Published in Biogerontology (Dordrecht) (01-10-2010)“…Alzheimer’s disease is an age-dependent neurodegenerative disorder characterized by loss of neurons, synaptic degeneration, senile plaques and neurofibrillary…”
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Ketogenic diets: An historical antiepileptic therapy with promising potentialities for the aging brain
Published in Ageing research reviews (01-07-2010)“…Abstract Ketogenic diets (KDs), successfully used in the therapy of paediatric epilepsy for nearly a century, have recently shown beneficial effects also in…”
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Effect of cognitive training on the expression of brain-derived neurotrophic factor in lymphocytes of mild cognitive impairment patients
Published in Rejuvenation research (01-04-2014)“…To identify biomarkers associated with cognitive stimulation of mild cognitive impairment (MCI) patients, we performed quantitative real-time reverse…”
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Release of beta-amyloid from high-density platelets: implications for Alzheimer's disease pathology
Published in Annals of the New York Academy of Sciences (01-01-2007)“…The main component of Alzheimer's disease (AD) senile plaques in the brain is amyloid-beta peptide (Abeta), a proteolytic fragment of the amyloid precursor…”
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A ketogenic diet increases succinic dehydrogenase (SDH) activity and recovers age-related decrease in numeric density of SDH-positive mitochondria in cerebellar Purkinje cells of late-adult rats
Published in Micron (Oxford, England : 1993) (01-02-2010)“…Ketogenic diets (KDs) have been applied in the therapy of paediatric epilepsy for nearly a century. Recently, beneficial results have also been reported on…”
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