Evaluation of UVC Excimer Lamp (222 nm) Efficacy for Coronavirus Inactivation in an Animal Model

Evaluation of UVC Excimer Lamp (222 nm) Efficacy for Coronavirus Inactivation in an Animal Model

The current pandemic caused by severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) has encouraged the evaluation of novel instruments for disinfection and lowering infectious pressure. Ultraviolet subtype C (UVC) excimer lamps with 222 nm wavelength have been tested on airborne path...

Full description

Saved in:
Bibliographic Details
Published in:Viruses Vol. 14; no. 9; p. 2038
Main Authors: Tucciarone, Claudia Maria, Cecchinato, Mattia, Vianello, Lucrezia, Simi, Gabriele, Borsato, Enrico, Silvestrin, Luca, Giorato, Michele, Salata, Cristiano, Morandin, Mauro, Greggio, Elisa, Drigo, Michele
Format: Journal Article
Language:English
Published: Basel MDPI AG 01-09-2022
MDPI
Subjects:
222 nm
Aerosols
Aluminum
animal model
Animal models
Bronchitis
Control
Coronaviruses
COVID-19
Disease transmission
Disinfection
Disinfection & disinfectants
Environmental conditions
excimer lamps
Health aspects
infectious bronchitis virus
Juveniles
Lamps
Medical research
Medicine, Experimental
Pandemics
Pathogens
Replication
Severe acute respiratory syndrome coronavirus 2
severe acute respiratory syndrome-related coronavirus-2
Systemic diseases
Testing
Ultraviolet radiation
UVC
Vaccines
Viruses
Wavelength
Italy
Basel Switzerland
United States > US
Switzerland
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The current pandemic caused by severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) has encouraged the evaluation of novel instruments for disinfection and lowering infectious pressure. Ultraviolet subtype C (UVC) excimer lamps with 222 nm wavelength have been tested on airborne pathogens on surfaces and the exposure to this wavelength has been considered safer than conventional UVC. To test the efficacy of UVC excimer lamps on coronaviruses, an animal model mimicking the infection dynamics was implemented. An attenuated vaccine based on infectious bronchitis virus (IBV) was nebulized and irradiated by 222 nm UVC rays before the exposure of a group of day-old chicks to evaluate the virus inactivation. A control group of chicks was exposed to the nebulized vaccine produced in the same conditions but not irradiated by the lamps. The animals of both groups were sampled daily and individually by choanal cleft swabs and tested usign a strain specific real time RT-PCR to evaluate the vaccine replication. Only the birds in the control group were positive, showing an active replication of the vaccine, revealing the efficacy of the lamps in inactivating the vaccine below the infectious dose in the other group.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1999-4915
1999-4915
DOI:10.3390/v14092038