Search Results - "Gionfriddo, Giulia"
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Investigation into the Use of Encorafenib to Develop Potential PROTACs Directed against BRAFV600E Protein
Published in Molecules (Basel, Switzerland) (03-12-2022)“…BRAF is a serine/threonine kinase frequently mutated in human cancers. BRAFV600E mutated protein is targeted through the use of kinase inhibitors which are…”
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Modulating Tumor-Associated Macrophage Polarization by Synthetic and Natural PPARγ Ligands as a Potential Target in Breast Cancer
Published in Cells (Basel, Switzerland) (10-01-2020)“…Activation of peroxisome proliferator-activated receptor gamma (PPARγ) elicits anti-proliferative effects on different tumor cells, including those derived…”
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Transcriptome‐wide gene expression outlier analysis pinpoints therapeutic vulnerabilities in colorectal cancer
Published in Molecular oncology (01-06-2024)“…Multiple strategies are continuously being explored to expand the drug target repertoire in solid tumors. We devised a novel computational workflow for…”
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DNA demethylation triggers cell free DNA release in colorectal cancer cells
Published in Genome medicine (09-10-2024)“…Liquid biopsy based on cell-free DNA (cfDNA) analysis holds significant promise as a minimally invasive approach for the diagnosis, genotyping, and monitoring…”
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N -Eicosapentaenoyl Dopamine, A Conjugate of Dopamine and Eicosapentaenoic Acid (EPA), Exerts Anti-inflammatory Properties in Mouse and Human Macrophages
Published in Nutrients (18-09-2019)“…A large body of evidence suggests that dietary -3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA),…”
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Investigation into the Use of Encorafenib to Develop Potential PROTACs Directed against BRAF[sup.V600E] Protein
Published in Molecules (Basel, Switzerland) (01-12-2022)“…BRAF is a serine/threonine kinase frequently mutated in human cancers. BRAF[sup.V600E] mutated protein is targeted through the use of kinase inhibitors which…”
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Ligand-activated PPARγ downregulates CXCR4 gene expression through a novel identified PPAR response element and inhibits breast cancer progression
Published in Oncotarget (04-10-2016)“…Stromal Derived Factor-1α (SDF-1α) and its cognate receptor CXCR4 play a key role in mediating breast cancer cell invasion and metastasis. Therefore, drugs…”
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Abstract LB058: A transcriptome-wide gene expression outlier analysis pinpoints therapeutic vulnerabilities in colorectal cancer
Published in Cancer research (Chicago, Ill.) (14-04-2023)“…Abstract The number of effective therapies approved for metastatic colorectal cancer (mCRC) is still limited and multiple strategies are continuously explored…”
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Investigation into the Use of Encorafenib to Develop Potential PROTACs Directed against BRAF V600E Protein
Published in Molecules (Basel, Switzerland) (03-12-2022)“…BRAF is a serine/threonine kinase frequently mutated in human cancers. BRAF mutated protein is targeted through the use of kinase inhibitors which are approved…”
Get full text
Journal Article