Search Results - "Gionco, John"

Histopathology of the cerebellar cortex in essential tremor and other neurodegenerative motor disorders: comparative analysis of 320 brains by Louis, Elan D., Martuscello, Regina T., Gionco, John T., Hartstone, Whitney G., Musacchio, Jessica B., Portenti, Marisa, McCreary, Morgan, Kuo, Sheng-Han, Vonsattel, Jean-Paul G., Faust, Phyllis L.

“…In recent years, numerous morphologic changes have been identified in the essential tremor (ET) cerebellar cortex, distinguishing ET from control brains. These…”
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Emerging Role of Environmental Epitranscriptomics and RNA Modifications in Parkinson’s Disease by Gionco, John T., Bernstein, Alison I.

“…Environmental risk factors and gene-environment interactions play a critical role in Parkinson’s disease (PD). However, the relatively large contribution of…”
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Essential Tremor versus “ET-plus”: A Detailed Postmortem Study of Cerebellar Pathology by Gionco, John T., Hartstone, Whitney G., Martuscello, Regina T., Kuo, Sheng-Han, Faust, Phyllis L., Louis, Elan D.

“…Essential tremor (ET) is among the most prevalent movement disorders, and by some accounts, the most common form of cerebellar degeneration. Over the past…”
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Pituitary corticotroph tumour with adrenocortical cells: A distinct clinicopathologic entity with unique morphology and methylation profile by Hickman, Richard A., Gionco, John T., Faust, Phyllis L., Miller, Michael L., Bruce, Jeffrey, Page‐Wilson, Gabrielle, Rosenblum, Marc K., Asa, Sylvia L.

“…We describe a rare TPIT‐positive corticotroph PitNET that is admixed with SF1‐positive adrenocortical cells. This dimorphous population of cells showed no…”
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Essential Tremor versus “ET-plus”: A Postmortem Study (1410) by Louis, Elan, Gionco, John, Hartstone, Whitney, Martuscello, Regina, Kuo, Sheng-Han, Faust, Phyllis

“…Abstract only…”
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KPT-9274, an Inhibitor of PAK4 and NAMPT, Leads to Downregulation of mTORC2 in Triple Negative Breast Cancer Cells by Cordover, Emma, Wei, Janet, Patel, Chadni, Shan, Naing Lin, Gionco, John, Sargsyan, Davit, Wu, Renyi, Cai, Li, Kong, Ah-Ng, Jacinto, Estela, Minden, Audrey

“…Triple negative breast cancer (TNBC) is difficult to treat due to lack of druggable targets. We have found that treatment with the small molecule inhibitor…”
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Increased Climbing Fiber Lateral Crossings on Purkinje Cell Dendrites in the Cerebellar Hemisphere in Essential Tremor by Wu, Yueh‐Chi, Louis, Elan D., Gionco, John, Pan, Ming‐Kai, Faust, Phyllis L., Kuo, Sheng‐Han

“…Background Climbing fibers (CFs) innervate Purkinje cells (PCs) with 1:1 relationship to ensure proper cerebellar function. Although CFs abnormally extend into…”
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Longitudinal single-cell transcriptional dynamics throughout neurodegeneration in SCA1 by Tejwani, Leon, Ravindra, Neal G, Lee, Changwoo, Cheng, Yubao, Nguyen, Billy, Luttik, Kimberly, Ni, Luhan, Zhang, Shupei, Morrison, Logan M, Gionco, John, Xiang, Yangfei, Yoon, Jennifer, Ro, Hannah, Haidery, Fatema, Grijalva, Rosalie M, Bae, Eunwoo, Kim, Kristen, Martuscello, Regina T, Orr, Harry T, Zoghbi, Huda Y, McLoughlin, Hayley S, Ranum, Laura P W, Shakkottai, Vikram G, Faust, Phyllis L, Wang, Siyuan, van Dijk, David, Lim, Janghoo

“…Neurodegeneration is a protracted process involving progressive changes in myriad cell types that ultimately results in the death of vulnerable neuronal…”
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SL-401, a Targeted Therapy Directed to the Interleukin-3 Receptor (CD123), and SL-801, a Reversible Inhibitor of Exportin-1 (XPO1), Display Synergistic Anti-Tumor Activity Against Hematologic Malignancies in Vitro by Gionco, John, Chen, Janice, Lindsay, Ross, Macri, Vince, Brooks, Christopher L.

“…Background: Novel combination therapies have shown success in combating tumor heterogeneity and drug resistance. SL-401 is a targeted therapy directed to the…”
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