Search Results - "Giocanti, N"

PARP inhibition versus PARP-1 silencing: different outcomes in terms of single-strand break repair and radiation susceptibility by Godon, Camille, Cordelières, Fabrice P, Biard, Denis, Giocanti, Nicole, Mégnin-Chanet, Frédérique, Hall, Janet, Favaudon, Vincent

“…The consequences of PARP-1 disruption or inhibition on DNA single-strand break repair (SSBR) and radio-induced lethality were determined in synchronized,…”
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Additive interaction of gefitinib ('Iressa', ZDI 839) and ionising radiation in human tumour cells in vitro by GIOCANTI, N, HENNEQUIN, C, ROUILLARD, D, DEFRANCE, R, FAVAUDON, V

“…Cultures of human carcinoma A-431, A-549 and HeLa cells were challenged with gamma-rays without or with concomitant exposure to gefitinib, a potent inhibitor…”
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Effectiveness of High Dose Bicalutamide and Concomitant Radiation Association in Prostate Cancer Cells by Quero, L, Giocanti, N, Hennequin, C, Hall, J, Favaudon, V

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S-phase specificity of cell killing by docetaxel (Taxotere) in synchronised HeLa cells by HENNEQUIN, C, GIOCANTI, N, FAVAUDON, V

“…Cell viability following short (1 h) contact with paclitaxel or docetaxel was assayed using synchronised HeLa cells. Docetaxel proved almost totally lethal…”
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Poly(ADP-ribose) polymerase, a major determinant of early cell response to ionizing radiation by Fernet, V. Ponette, E. Deniaud-Alexandre, J. Ménissier De-Murcia, G. De Murcia, N. Giocanti, F. Megnin-Chanet, V. Favaudon, M.

“…Purpose : To determine whether DNA-dependent protein kinase (DNA-PK) and poly(ADP-ribose) polymerase (PARP-1) are involved in eliciting the rapid fluctuations…”
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Hyperfast, early cell response to ionizing radiation by Ponette, C. Le Péchoux, E. Deniaud-Alexandre, M. Fernet, N. Giocanti, H. Tourbez, V. Favaudon, V.

“…Purpose : To determine whether the oscillatory changes of radiosensitivity which occur within fractions of a second to a few minutes following flash…”
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Radiation-induced arrest of cells in G2 phase elicits hypersensitivity to DNA double-strand break inducers and an altered pattern of DNA cleavage upon re-irradiation by Yu, N. Giocanti, D. Averbeck, F. Megnin-Chanet, V. Favaudon, Y.-Q.

“…Purpose : To determine how radiation-induced arrest in G2 affects the response of mammalian cells to a challenging dose of radiation or to antitumour drugs…”
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Additive and supraadditive interaction between ionizing radiation and pazelliptine, a DNA topoisomerase inhibitor, in Chinese hamster V-79 fibroblasts by BALOSSO, J, GIOCANTI, N, FAVAUDON, V

“…The cytotoxic effect of the 9-azaellipticine derivative pazelliptine in combination with gamma-ray irradiation was investigated using Chinese hamster V-79…”
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Interaction of ionizing radiation with paclitaxel (taxol) and docetaxel (taxotere) in HeLa and SQ20B cells by HENNEQUIN, C, GIOCANTI, N, FAVAUDON, V

“…Altered gamma-ray response by brief (1 h), concomitant exposure to paclitaxel (Taxol) or docetaxel (Taxotere) was investigated in growing HeLa and SQ20B human…”
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La protéine kinase dépendante de l'ADN (DNA-PK), une enzyme clé de la religation des cassures double-brin de l'ADN by Hennequin, C., Giocanti, N., Averbeck, D., Favaudon, V.

“…Les mécanismes de réparation de l'ADN sont de mieux en mieux connus. Parmi eux, la religation directe ( non-homologous end-joining [NHEJ]) joue un rôle…”
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Radiochemical cross-linking between proteins and RNA within 70 S ribosomal particles from E. coli MRE600 by Giocanti, N, Ekert, B

“…In the absence of oxygen, gamma-irradiation produces covalent links between some ribosomal proteins and 16 S RNA to 23 S RNA, within 70 S ribosomes from E…”
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Study of several factors in RNA-protein cross-link formation induced by ionizing radiations within 70S ribosomes of E. coli MRE 600 by Ekert, B, Giocanti, N, Sabattier, R

“…The induction of RNA-protein crosslinks in E. coli 70S ribosomes by gamma-irradiation was studied by measuring the dependence of cross-link formation on…”
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Protein-RNA crosslinks in ribosomes: ultraviolet action spectra. Comparison with inactivation action spectrum by Muel, B, Giocanti, N, Ekert, B

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Pulse treatment of interphasic HeLa cells with nanomolar doses of docetaxel affects centrosome organization and leads to catastrophic exit of mitosis by Paoletti, A, Giocanti, N, Favaudon, V, Bornens, M

“…In order to investigate the role of centrosome duplication in mitotic spindle morphogenesis, we designed a 1 hour pulse treatment protocol on synchronized HeLa…”
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Synthesis and in vitro evaluation of novel 2,6,9-trisubstituted purines acting as cyclin-dependent kinase inhibitors by LEGRAVEREND, M, LUDWIG, O, BISAGNI, E, LECLERC, S, MEIJER, L, GIOCANTI, N, SADRI, R, FAVAUDON, V

“…Novel C-2, C-6, N-9 trisubstituted purines derived from the olomoucine/roscovitine lead structure were synthesized and evaluated for their ability to inhibit…”
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Pulse exposure to ionizing radiation elicits rapid changes in cellular radiosensitivity by Ponette, V, Giocanti, N, Tourbez, H, Balosso, J, Hennequin, C, Favaudon, V

“…A linear electron accelerator, operated in a recurrent chopped mode, was used for time-resolved investigation of split-dose radiation recovery in 3 mammalian…”
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Targeted therapies and radiotherapy by Hennequin, Christophe, Giocanti, Nicole, Favaudon, Vincent

“…Targeted therapies are at this moment the subject of an intensive research program. Their action is, however, for most of them, cytostatic, and their…”
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Interaction of ionizing radiation with the topoisomerase I poison camptothecin in growing V-79 and HeLa cells by HENNEQUIN, C, GIOCANTI, N, BALOSSO, J, FAVAUDON, V

“…Interaction between gamma-rays and camptothecin (CPT) was investigated in vitro, using log phase HeLa-S3 cells and Chinese hamster V-79 fibroblasts. A plateau…”
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537 POSTER Increased radiation susceptibility by poly(ADP-ribose) polymerase inhibitors is restricted to the S phase of the cell cycle and involves loss of control of replication forks by Godon, C., Noel, G., Fernet, M., Giocanti, N., Megnin-Chanet, F., Favaudon, V.

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DNA repair and cell cycle interactions in radiation sensitization by the topoisomerase II poison etoposide by GIOCANTI, N, HENNEQUIN, C, BALOSSO, J, MAHLER, M, FAVAUDON, V

“…The interactions between ionizing radiation and etoposide were probed using asynchronous growing V-79 fibroblasts. Synergistic cell kill was observed as…”
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