Search Results - "Ginsberg, H N"

Fenofibrate-associated changes in renal function and relationship to clinical outcomes among individuals with type 2 diabetes: the Action to Control Cardiovascular Risk in Diabetes (ACCORD) experience by Bonds, D. E., Craven, T. E., Buse, J., Crouse, J. R., Cuddihy, R., Elam, M., Ginsberg, H. N., Kirchner, K., Marcovina, S., Mychaleckyj, J. C., O’Connor, P. J., Sperl-Hillen, J.-A.

“…Aims/hypothesis Fenofibrate has been noted to cause an elevation in serum creatinine in some individuals. Participants in the Action to Control Cardiovascular…”
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Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society by Cuchel, Marina, Bruckert, Eric, Ginsberg, Henry N, Raal, Frederick J, Santos, Raul D, Hegele, Robert A, Kuivenhoven, Jan Albert, Nordestgaard, Børge G, Descamps, Olivier S, Steinhagen-Thiessen, Elisabeth, Tybjærg-Hansen, Anne, Watts, Gerald F, Averna, Maurizio, Boileau, Catherine, Borén, Jan, Catapano, Alberico L, Defesche, Joep C, Hovingh, G Kees, Humphries, Steve E, Kovanen, Petri T, Masana, Luis, Pajukanta, Päivi, Parhofer, Klaus G, Ray, Kausik K, Stalenhoef, Anton F H, Stroes, Erik, Taskinen, Marja-Riitta, Wiegman, Albert, Wiklund, Olov, Chapman, M John

“…Homozygous familial hypercholesterolaemia (HoFH) is a rare life-threatening condition characterized by markedly elevated circulating levels of low-density…”
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Regulation of hepatic secretion of apolipoprotein B-containing lipoproteins: information obtained from cultured liver cells by Dixon, JL, Ginsberg, HN

“…A major theme of this review is that apoB secretion is regulated post-translationally, and that apoB secretion reacts rapidly to the current state of lipid…”
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Overexpression of the A1 adenosine receptor in adipose tissue protects mice from obesity-related insulin resistance by Dong, Q., Ginsberg, H. N., Erlanger, B. F.

“…Summary In‐vitro studies have implicated the A1 adenosine receptor (A1AR) of adipocytes in inhibition of lipolysis, stimulation of lipogenesis and enhancement…”
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Lipoprotein physiology by Ginsberg, H N

“…Lipoproteins are spherical macromolecular complexes in which hydrophobic molecules of triglyceride and cholesteryl ester are enveloped within a monolayer of…”
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Oleate stimulates secretion of apolipoprotein B-containing lipoproteins from Hep G2 cells by inhibiting early intracellular degradation of apolipoprotein B by Dixon, J L, Furukawa, S, Ginsberg, H N

“…Studies were conducted to explore the effects of oleate addition on the secretion of apolipoprotein B (apoB)-containing lipoproteins from Hep G2 cells. Whether…”
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Effects of Reducing Dietary Saturated Fatty Acids on Plasma Lipids and Lipoproteins in Healthy Subjects: The Delta Study, Protocol 1 by Ginsberg, Henry N, Kris-Etherton, Penny, Dennis, Barbara, Elmer, Patricia J, Ershow, Abby, Lefevre, Michael, Pearson, Thomas, Roheim, Paul, Ramakrishnan, Rajasekhar, Reed, Roberta, Stewart, Kent, Stewart, Paul, Phillips, Katherine, Anderson, Nancy

“…Few well-controlled diet studies have investigated the effects of reducing dietary saturated fatty acid (SFA) intake in premenopausal and postmenopausal women…”
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Insulin resistance and cardiovascular disease by Ginsberg, H N

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Diabetic dyslipidemia : Basic mechanisms underlying the common hypertriglyceridemia and low HDL cholesterol levels by GINSBERG, H. N

“…Elevated levels of plasma triglycerides (TG) and reduced concentrations of HDL cholesterol are very common in patients with diabetes, particularly NIDDM…”
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Effects of Statins on Triglyceride Metabolism by Ginsberg, Henry N

“…Hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, or “statins,” have been extremely efficacious in decreasing low-density…”
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Nonpharmacologic management of low levels of high-density lipoprotein cholesterol by Ginsberg, Henry N

“…Several nonpharmacologic approaches can effectively increase low serum levels of high-density lipoprotein cholesterol (HDL-C), including weight control,…”
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Lovastatin therapy reduces low density lipoprotein apoB levels in subjects with combined hyperlipidemia by reducing the production of apoB-containing lipoproteins: implications for the pathophysiology of apoB production by Arad, Y, Ramakrishnan, R, Ginsberg, HN

“…We investigated the metabolism of very low density lipoprotein (VLDL), intermediate density lipoprotein (IDL), and low density lipoprotein (LDL) apolipoprotein…”
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Proteolysis and lipid-facilitated translocation are distinct but competitive processes that regulate secretion of apolipoprotein B in Hep G2 cells by Sakata, N, Wu, X, Dixon, J.L, Ginsberg, H.N

“…Under lipid-poor conditions, most newly synthesized apolipoprotein B100 (apoB) undergoes rapid degradation in Hep G2 cells such that only a small fraction of…”
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Mechanism of hypertriglyceridemia in human apolipoprotein (Apo) CIII transgenic mice : diminished very low density lipoprotein fractional catabolic rate associated with increased apo CIII and reduced apo E on the particles by AALTO-SETÄLÄ, A, FISHER, E. A, XIAOLI CHEN, CHAJEK-SHAUL, T, HAYEK, T, ZECHNER, R, WALSH, A, RAJASEKHAR RAMAKRISHNAN, GINSBERG, H. N, BRESLOW, J. L

“…Hypertriglyceridemia is common in the general population, but its mechanism is largely unknown. In previous work human apo CIII transgenic (HuCIIITg) mice were…”
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Lipoprotein physiology in nondiabetic and diabetic states--relationship to atherogenesis by Ginsberg, H.N

“…Abnormalities of plasma lipid and lipoprotein concentrations are common in both insulin-dependent (IDDM) and non-insulin-dependent (NIDDM) diabetes mellitus…”
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Studies of the sites of intracellular degradation of apolipoprotein B in Hep G2 cells by FURUKAWA, S, SAKATA, N, GINSBERG, H. N, DIXON, J. L

“…We previously reported that treatment of Hep G2 cells with oleate significantly increased apolipoprotein B (apoB) secretion by reducing early intracellular…”
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Is hypertriglyceridemia a risk factor for atherosclerotic cardiovascular disease? A simple question with a complicated answer by GINSBERG, H. N

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Overexpression of apolipoprotein CII causes hypertriglyceridemia in transgenic mice by SHACHTER, N. S, HAYEK, T, LEFF, T, SMITH, J. D, ROSENBERG, D. W, WALSH, A, RAJASEKHAR RAMAKRISHNAN, GOLDBERG, I. J, GINSBERG, H. N, BRESLOW, J. L

“…We have generated transgenic mice expressing the human apolipoprotein CII (apoCII) gene under the transcriptional control of the human cytochrome P-450 IA1…”
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Increased concentration of plasma cholesteryl ester transfer protein in nephrotic syndrome: role in dyslipidemia by Moulin, P, Appel, GB, Ginsberg, HN, Tall, AR

“…Hyperlipidemia is a prominent feature of the nephrotic syndrome. Lipoprotein abnormalities include increased very low and low density lipoprotein (VLDL and…”
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Increased plasma and renal clearance of an exchangeable pool of apolipoprotein A-I in subjects with low levels of high density lipoprotein cholesterol by HOROWITZ, B. S, GOLDBERG, I. J, MERAB, J, VANNI, T. M, RAJASEKHAR RAMAKRISHNAN, GINSBERG, H. N

“…Plasma levels of HDL apo A-I are reduced in individuals with low HDL cholesterol (HDL-C) concentrations as a result of increased fractional catabolic rates…”
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