Studies on Ruta chalepensis, an ancient medicinal herb still used in traditional medicine

An ethanolic extract of the aerial parts of Ruta chalepensis was studied for its anti-inflammatory, antipyretic, analgesic and CNS depressant activities. The extract produced a significant inhibition of carrageenan-induced paw oedema and cotton pellet granuloma in rats. The studies on spontaneous mo...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of ethnopharmacology Vol. 28; no. 3; p. 305
Main Authors:	al-Said, M S, Tariq, M, al-Yahya, M A, Rafatullah, S, Ginnawi, O T, Ageel, A M
Format:	Journal Article
Language:	English
Published:	Ireland 01-03-1990
Subjects:	Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Granuloma, Foreign-Body - chemically induced Mice Motor Activity - drug effects Phytotherapy Plant Extracts - pharmacology Rats
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	An ethanolic extract of the aerial parts of Ruta chalepensis was studied for its anti-inflammatory, antipyretic, analgesic and CNS depressant activities. The extract produced a significant inhibition of carrageenan-induced paw oedema and cotton pellet granuloma in rats. The studies on spontaneous motor activity in mice and conditioned avoidance responding (CAR) in rats showed a dose-dependent depression of the central nervous system in treated animals. Reduction of yeast-induced hyperthermia in mice confirmed its reputed antipyretic activity. The extract did not produce any significant changes in prothrombin time and fibrinogen level. It also failed to produce any analgesic activity in the hot plate reaction-time test in mice. Phytochemical screening of the aerial parts of the plant showed the presence of alkaloids, flavonoids, coumarins, tannins, volatile oil, sterols and/or triterpenes.
ISSN:	0378-8741
DOI:	10.1016/0378-8741(90)90081-4