Search Results - "Ginn, Helen M."

Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike by Huo, Jiandong, Zhao, Yuguang, Ren, Jingshan, Zhou, Daming, Duyvesteyn, Helen M.E., Ginn, Helen M., Carrique, Loic, Malinauskas, Tomas, Ruza, Reinis R., Shah, Pranav N.M., Tan, Tiong Kit, Rijal, Pramila, Coombes, Naomi, Bewley, Kevin R., Tree, Julia A., Radecke, Julika, Paterson, Neil G., Supasa, Piyada, Mongkolsapaya, Juthathip, Screaton, Gavin R., Carroll, Miles, Townsend, Alain, Fry, Elizabeth E., Owens, Raymond J., Stuart, David I.

“…There are as yet no licensed therapeutics for the COVID-19 pandemic. The causal coronavirus (SARS-CoV-2) binds host cells via a trimeric spike whose receptor…”
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Potent cross-reactive antibodies following Omicron breakthrough in vaccinees by Nutalai, Rungtiwa, Zhou, Daming, Tuekprakhon, Aekkachai, Ginn, Helen M., Supasa, Piyada, Liu, Chang, Huo, Jiandong, Mentzer, Alexander J., Duyvesteyn, Helen M.E., Dijokaite-Guraliuc, Aiste, Skelly, Donal, Ritter, Thomas G., Amini, Ali, Bibi, Sagida, Adele, Sandra, Johnson, Sile Ann, Constantinides, Bede, Webster, Hermione, Temperton, Nigel, Klenerman, Paul, Barnes, Eleanor, Dunachie, Susanna J., Crook, Derrick, Pollard, Andrew J., Lambe, Teresa, Goulder, Philip, Paterson, Neil G., Williams, Mark A., Hall, David R., Mongkolsapaya, Juthathip, Fry, Elizabeth E., Dejnirattisai, Wanwisa, Ren, Jingshan, Stuart, David I., Screaton, Gavin R.

“…Highly transmissible Omicron variants of SARS-CoV-2 currently dominate globally. Here, we compare neutralization of Omicron BA.1, BA.1.1, and BA.2. BA.2 RBD…”
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Machining protein microcrystals for structure determination by electron diffraction by Duyvesteyn, Helen M. E., Kotecha, Abhay, Ginn, Helen M., Hecksel, Corey W., Beale, Emma V., de Haas, Felix, Evans, Gwyndaf, Zhang, Peijun, Chiu, Wah, Stuart, David I.

“…We demonstrate that ion-beam milling of frozen, hydrated protein crystals to thin lamella preserves the crystal lattice to near-atomic resolution. This…”
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The antibody response to SARS-CoV-2 Beta underscores the antigenic distance to other variants by Liu, Chang, Zhou, Daming, Nutalai, Rungtiwa, Duyvesteyn, Helen M.E., Tuekprakhon, Aekkachai, Ginn, Helen M., Dejnirattisai, Wanwisa, Supasa, Piyada, Mentzer, Alexander J., Wang, Beibei, Case, James Brett, Zhao, Yuguang, Skelly, Donal T., Chen, Rita E., Johnson, Sile Ann, Ritter, Thomas G., Mason, Chris, Malik, Tariq, Temperton, Nigel, Paterson, Neil G., Williams, Mark A., Hall, David R., Clare, Daniel K., Howe, Andrew, Goulder, Philip J.R., Fry, Elizabeth E., Diamond, Michael S., Mongkolsapaya, Juthathip, Ren, Jingshan, Stuart, David I., Screaton, Gavin R.

“…Alpha-B.1.1.7, Beta-B.1.351, Gamma-P.1, and Delta-B.1.617.2 variants of SARS-CoV-2 express multiple mutations in the spike protein (S). These may alter the…”
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Where is crystallography going? by Grimes, Jonathan M., Hall, David R., Ashton, Alun W., Evans, Gwyndaf, Owen, Robin L., Wagner, Armin, McAuley, Katherine E., von Delft, Frank, Orville, Allen M., Sorensen, Thomas, Walsh, Martin A., Ginn, Helen M., Stuart, David I.

“…Macromolecular crystallography (MX) has been a motor for biology for over half a century and this continues apace. A series of revolutions, including the…”
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Structure of CPV17 polyhedrin determined by the improved analysis of serial femtosecond crystallographic data by Ginn, Helen M., Messerschmidt, Marc, Ji, Xiaoyun, Zhang, Hanwen, Axford, Danny, Gildea, Richard J., Winter, Graeme, Brewster, Aaron S., Hattne, Johan, Wagner, Armin, Grimes, Jonathan M., Evans, Gwyndaf, Sauter, Nicholas K., Sutton, Geoff, Stuart, David I.

“…The X-ray free-electron laser (XFEL) allows the analysis of small weakly diffracting protein crystals, but has required very many crystals to obtain good data…”
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Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background graphene by Seuring, Carolin, Ayyer, Kartik, Filippaki, Eleftheria, Barthelmess, Miriam, Longchamp, Jean-Nicolas, Ringler, Philippe, Pardini, Tommaso, Wojtas, David H., Coleman, Matthew A., Dörner, Katerina, Fuglerud, Silje, Hammarin, Greger, Habenstein, Birgit, Langkilde, Annette E., Loquet, Antoine, Meents, Alke, Riek, Roland, Stahlberg, Henning, Boutet, Sébastien, Hunter, Mark S., Koglin, Jason, Liang, Mengning, Ginn, Helen M., Millane, Rick P., Frank, Matthias, Barty, Anton, Chapman, Henry N.

“…Here we present a new approach to diffraction imaging of amyloid fibrils, combining a free-standing graphene support and single nanofocused X-ray pulses of…”
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Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike by Huo, Jiandong, Zhao, Yuguang, Ren, Jingshan, Zhou, Daming, Duyvesteyn, Helen M.E., Ginn, Helen M., Carrique, Loic, Malinauskas, Tomas, Ruza, Reinis R., Shah, Pranav N.M., Tan, Tiong Kit, Rijal, Pramila, Coombes, Naomi, Bewley, Kevin R., Tree, Julia A., Radecke, Julika, Paterson, Neil G., Supasa, Piyada, Mongkolsapaya, Juthathip, Screaton, Gavin R., Carroll, Miles, Townsend, Alain, Fry, Elizabeth E., Owens, Raymond J., Stuart, David I.

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Pre‐clustering data sets using cluster4x improves the signal‐to‐noise ratio of high‐throughput crystallography drug‐screening analysis by Ginn, Helen M.

“…Drug and fragment screening at X‐ray crystallography beamlines has been a huge success. However, it is inevitable that more high‐profile biological drug…”
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An ultraviolet-driven rescue pathway for oxidative stress to eye lens protein human gamma-D crystallin by Hill, Jake A., Nyathi, Yvonne, Horrell, Sam, von Stetten, David, Axford, Danny, Owen, Robin L., Beddard, Godfrey S., Pearson, Arwen R., Ginn, Helen M., Yorke, Briony A.

“…Human gamma-D crystallin (HGD) is a major constituent of the eye lens. Aggregation of HGD contributes to cataract formation, the leading cause of blindness…”
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Vagabond: bond‐based parametrization reduces overfitting for refinement of proteins by Ginn, Helen M.

“…Structural biology methods have delivered over 150 000 high‐resolution structures of macromolecules, which have fundamentally altered our understanding of…”
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Robust and automatic beamstop shadow outlier rejection: combining crystallographic statistics with modern clustering under a semi‐supervised learning strategy by Gao, Yunyun, Ginn, Helen M., Thorn, Andrea

“…During the automatic processing of crystallographic diffraction experiments, beamstop shadows are often unaccounted for or only partially masked. As a result…”
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Antibody evasion by the P.1 strain of SARS-CoV-2 by Dejnirattisai, Wanwisa, Zhou, Daming, Supasa, Piyada, Liu, Chang, Mentzer, Alexander J., Ginn, Helen M., Zhao, Yuguang, Duyvesteyn, Helen M.E., Tuekprakhon, Aekkachai, Nutalai, Rungtiwa, Wang, Beibei, López-Camacho, César, Slon-Campos, Jose, Walter, Thomas S., Skelly, Donal, Costa Clemens, Sue Ann, Naveca, Felipe Gomes, Nascimento, Valdinete, Nascimento, Fernanda, Fernandes da Costa, Cristiano, Resende, Paola Cristina, Pauvolid-Correa, Alex, Siqueira, Marilda M., Dold, Christina, Levin, Robert, Dong, Tao, Pollard, Andrew J., Knight, Julian C., Crook, Derrick, Lambe, Teresa, Clutterbuck, Elizabeth, Bibi, Sagida, Flaxman, Amy, Bittaye, Mustapha, Belij-Rammerstorfer, Sandra, Gilbert, Sarah C., Carroll, Miles W., Klenerman, Paul, Barnes, Eleanor, Dunachie, Susanna J., Paterson, Neil G., Williams, Mark A., Hall, David R., Hulswit, Ruben J.G., Bowden, Thomas A., Fry, Elizabeth E., Mongkolsapaya, Juthathip, Ren, Jingshan, Stuart, David I., Screaton, Gavin R.

“…Terminating the SARS-CoV-2 pandemic relies upon pan-global vaccination. Current vaccines elicit neutralizing antibody responses to the virus spike derived from…”
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Assembly of Differently Sized Supercharged Protein Nanocages into Superlattices for Construction of Binary Nanoparticle–Protein Materials by Rütten, Michael, Lang, Laurin, Wagler, Henrike, Lach, Marcel, Mucke, Niklas, Laugks, Ulrike, Seuring, Carolin, Keller, Thomas F., Stierle, Andreas, Ginn, Helen M., Beck, Tobias

“…This study focuses on the design and characterization of binary nanoparticle superlattices: Two differently sized, supercharged protein nanocages are used to…”
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Proteins' Knotty Problems by Jarmolinska, Aleksandra I., Perlinska, Agata P., Runkel, Robert, Trefz, Benjamin, Ginn, Helen M., Virnau, Peter, Sulkowska, Joanna I.

“…Knots in proteins are increasingly being recognized as an important structural concept, and the folding of these peculiar structures still poses considerable…”
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High-speed fixed-target serial virus crystallography by Roedig, Philip, Ginn, Helen M, Pakendorf, Tim, Sutton, Geoff, Harlos, Karl, Walter, Thomas S, Meyer, Jan, Fischer, Pontus, Duman, Ramona, Vartiainen, Ismo, Reime, Bernd, Warmer, Martin, Brewster, Aaron S, Young, Iris D, Michels-Clark, Tara, Sauter, Nicholas K, Kotecha, Abhay, Kelly, James, Rowlands, David J, Sikorsky, Marcin, Nelson, Silke, Damiani, Daniel S, Alonso-Mori, Roberto, Ren, Jingshan, Fry, Elizabeth E, David, Christian, Stuart, David I, Wagner, Armin, Meents, Alke

“…A new sample-delivery method for serial X-ray crystallography exploits the full repetition rate of the X-ray free-electron laser at the LCLS facility, thus…”
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Structure-based energetics of protein interfaces guides foot-and-mouth disease virus vaccine design by Kotecha, Abhay, Seago, Julian, Scott, Katherine, Burman, Alison, Loureiro, Silvia, Ren, Jingshan, Porta, Claudine, Ginn, Helen M, Jackson, Terry, Perez-Martin, Eva, Siebert, C Alistair, Paul, Guntram, Huiskonen, Juha T, Jones, Ian M, Esnouf, Robert M, Fry, Elizabeth E, Maree, Francois F, Charleston, Bryan, Stuart, David I

“…Foot-and-mouth disease virus (FMDV) capsids are often unstable, thus limiting their use as vaccines. A computational method was used to strengthen…”
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A delicate balance between antibody evasion and ACE2 affinity for Omicron BA.2.75 by Huo, Jiandong, Dijokaite-Guraliuc, Aiste, Liu, Chang, Zhou, Daming, Ginn, Helen M., Das, Raksha, Supasa, Piyada, Selvaraj, Muneeswaran, Nutalai, Rungtiwa, Tuekprakhon, Aekkachai, Duyvesteyn, Helen M.E., Mentzer, Alexander J., Skelly, Donal, Ritter, Thomas G., Amini, Ali, Bibi, Sagida, Adele, Sandra, Johnson, Sile Ann, Paterson, Neil G., Williams, Mark A., Hall, David R., Plowright, Megan, Newman, Thomas A.H., Hornsby, Hailey, de Silva, Thushan I., Temperton, Nigel, Klenerman, Paul, Barnes, Eleanor, Dunachie, Susanna J., Pollard, Andrew J., Lambe, Teresa, Goulder, Philip, Fry, Elizabeth E., Mongkolsapaya, Juthathip, Ren, Jingshan, Stuart, David I., Screaton, Gavin R.

“…Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have caused successive global waves of infection. These variants, with multiple…”
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Fixed target combined with spectral mapping: approaching 100% hit rates for serial crystallography by Oghbaey, Saeed, Sarracini, Antoine, Ginn, Helen M., Pare-Labrosse, Olivier, Kuo, Anling, Marx, Alexander, Epp, Sascha W., Sherrell, Darren A., Eger, Bryan T., Zhong, Yinpeng, Loch, Rolf, Mariani, Valerio, Alonso-Mori, Roberto, Nelson, Silke, Lemke, Henrik T., Owen, Robin L., Pearson, Arwen R., Stuart, David I., Ernst, Oliver P., Mueller-Werkmeister, Henrike M., Miller, R. J. Dwayne

“…The advent of ultrafast highly brilliant coherent X‐ray free‐electron laser sources has driven the development of novel structure‐determination approaches for…”
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Polyhedra structures and the evolution of the insect viruses by Ji, Xiaoyun, Axford, Danny, Owen, Robin, Evans, Gwyndaf, Ginn, Helen M., Sutton, Geoff, Stuart, David I.

“…Polyhedra represent an ancient system used by a number of insect viruses to protect virions during long periods of environmental exposure. We present high…”
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