Search Results - "Gingrich, E."

Controllable 0–π Josephson junctions containing a ferromagnetic spin valve by Gingrich, E. C., Niedzielski, Bethany M., Glick, Joseph A., Wang, Yixing, Miller, D. L., Loloee, Reza, Pratt Jr, W. P., Birge, Norman O.

“…Josephson junctions incorporating ferromagnetic spin valves are shown to be switchable between the 0 and π states, opening up interesting wider implications…”
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Discovery of Clinical Candidate CEP-37440, a Selective Inhibitor of Focal Adhesion Kinase (FAK) and Anaplastic Lymphoma Kinase (ALK) by Ott, Gregory R, Cheng, Mangeng, Learn, Keith S, Wagner, Jason, Gingrich, Diane E, Lisko, Joseph G, Curry, Matthew, Mesaros, Eugen F, Ghose, Arup K, Quail, Matthew R, Wan, Weihua, Lu, Lihui, Dobrzanski, Pawel, Albom, Mark S, Angeles, Thelma S, Wells-Knecht, Kevin, Huang, Zeqi, Aimone, Lisa D, Bruckheimer, Elizabeth, Anderson, Nathan, Friedman, Jay, Fernandez, Sandra V, Ator, Mark A, Ruggeri, Bruce A, Dorsey, Bruce D

“…Analogues structurally related to anaplastic lymphoma kinase (ALK) inhibitor 1 were optimized for metabolic stability. The results from this endeavor not only…”
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Evaluation of thermal processing and properties of 422 martensitic stainless steel for replacement of 4140 steel in diesel engine pistons by Pierce, D.T., Muralidharan, G., Trofimov, A., Torres, J., Wang, H., Haynes, J.A., Sebeck, K., Gingrich, E., Byrd, G., Tess, M.

“…[Display omitted] •Tempering from 600 to 700 °C substantially modifies elevated temperature strength of 422 but has no significant influence on thermal…”
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Depletion of autoreactive plasma cells and treatment of lupus nephritis in mice using CEP-33779, a novel, orally active, selective inhibitor of JAK2 by Lu, Lily D, Stump, Kristine L, Wallace, Nate H, Dobrzanski, Pawel, Serdikoff, Cynthia, Gingrich, Diane E, Dugan, Benjamin J, Angeles, Thelma S, Albom, Mark S, Mason, Jennifer L, Ator, Mark A, Dorsey, Bruce D, Ruggeri, Bruce A, Seavey, Matthew M

“…Accumulating evidence suggests that autoreactive plasma cells play an important role in systemic lupus erythematosus (SLE). In addition, several…”
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A highly selective, orally active inhibitor of Janus kinase 2, CEP-33779, ablates disease in two mouse models of rheumatoid arthritis by Stump, Kristine L, Lu, Lily D, Dobrzanski, Pawel, Serdikoff, Cynthia, Gingrich, Diane E, Dugan, Ben J, Angeles, Thelma S, Albom, Mark S, Ator, Mark A, Dorsey, Bruce D, Ruggeri, Bruce A, Seavey, Matthew M

“…Janus kinase 2 (JAK2) is involved in the downstream activation of signal transducer and activator of transcription 3 (STAT3) and STAT5 and is responsible for…”
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Development of vascular endothelial growth factor receptor (VEGFR) kinase inhibitors as anti-angiogenic agents in cancer therapy by Underiner, T L, Ruggeri, B, Gingrich, D E

“…Among the known angiogenic growth factors and cytokines implicated in the modulation of normal and pathological angiogenesis, the VEGF family (VEGF-A, VEGF-B,…”
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Atmospherically Derived Organic Surface Films along an Urban-Rural Gradient by Gingrich, Sarah E, Diamond, Miriam L, Stern, Gary A, McCarry, Brian E

“…Atmospherically derived organic films have been found on an impervious surface along an urban-rural gradient in the Toronto, Ontario, Canada area. Film…”
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Discovery of an Orally Efficacious Inhibitor of Anaplastic Lymphoma Kinase by Gingrich, Diane E, Lisko, Joseph G, Curry, Matthew A, Cheng, Mangeng, Quail, Matthew, Lu, Lihui, Wan, Weihua, Albom, Mark S, Angeles, Thelma S, Aimone, Lisa D, Haltiwanger, R. Curtis, Wells-Knecht, Kevin, Ott, Gregory R, Ghose, Arup K, Ator, Mark A, Ruggeri, Bruce, Dorsey, Bruce D

“…Anaplastic lymphoma kinase (ALK) is a promising therapeutic target for the treatment of cancer, supported by considerable favorable preclinical and clinical…”
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Advances in the development of kinase inhibitor therapeutics for Alzheimer's disease by Savage, Mary J., Gingrich, Diane E.

“…Pharmaceutical approaches to slow the progression of Alzheimer's disease (AD) have focused primarily on reducing production or increasing clearance of amyloid…”
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Evidence for Organic Film on an Impervious Urban Surface:  Characterization and Potential Teratogenic Effects by Diamond, Miriam L, Gingrich, Sarah E, Fertuck, Kirsten, McCarry, Brian E, Stern, Gary A, Billeck, Brian, Grift, Bert, Brooker, Deborah, Yager, Thomas D

“…Chemical constituents of an organic film collected from an impervious urban surface, namely the exterior surface of windows, have been characterized. The…”
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Intestinal parasites of dogs on the Galapagos Islands by Gingrich, E.N., Scorza, A.V., Clifford, E.L., Olea-Popelka, F.J., Lappin, M.R.

“…Dogs on the Galapagos Islands are a unique population created by isolation from the mainland and regulations prohibiting further importation. The effect of…”
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Accumulation of metals, trace elements and semi-volatile organic compounds on exterior window surfaces in Baltimore by Liu, Qin-Tao, Diamond, Miriam L, Gingrich, Sarah E, Ondov, John M, Maciejczyk, Polina, Stern, Gary A

“…Organic films on windows are associated with elevated VOC and SOC emissions to urban air. Organic films have been found to develop on window surfaces [Diamond…”
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A New Class of Potent Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors:  Structure−Activity Relationships for a Series of 9-Alkoxymethyl-12-(3-hydroxypropyl)indeno[2,1-a]pyrrolo[3,4-c]carbazole-5-ones and the Identification of CEP-5214 and Its Dimethylglycine Ester Prodrug Clinical Candidate CEP-7055 by Gingrich, Diane E, Reddy, Dandu R, Iqbal, Mohamed A, Singh, Jasbir, Aimone, Lisa D, Angeles, Thelma S, Albom, Mark, Yang, Shi, Ator, Mark A, Meyer, Sheryl L, Robinson, Candy, Ruggeri, Bruce A, Dionne, Craig A, Vaught, Jeffry L, Mallamo, John P, Hudkins, Robert L

“…A series of potent vascular endothelial growth factor R2 (VEGF-R2) tyrosine kinase inhibitors from a new indenopyrrolocarbazole template is reported. The…”
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Anatomy of Heat Waves and Mortality in Toronto: Lessons for Public Health Protection by Pengelly, L. David, Campbell, Monica E., Cheng, Chad S., Fu, Chao, Gingrich, Sarah E., Macfarlane, Ronald

“…Background: Periods of unusually hot weather, especially in temperate climates, carry with them a burden of morbidity and mortality, particularly in urban…”
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CEP-28122, a highly potent and selective orally active inhibitor of anaplastic lymphoma kinase with antitumor activity in experimental models of human cancers by Cheng, Mangeng, Quail, Matthew R, Gingrich, Diane E, Ott, Gregory R, Lu, Lihui, Wan, Weihua, Albom, Mark S, Angeles, Thelma S, Aimone, Lisa D, Cristofani, Flavio, Machiorlatti, Rodolfo, Abele, Cristina, Ator, Mark A, Dorsey, Bruce D, Inghirami, Giorgio, Ruggeri, Bruce A

“…Anaplastic lymphoma kinase (ALK) is constitutively activated in a number of human cancer types due to chromosomal translocations, point mutations, and gene…”
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A Selective, Orally Bioavailable 1,2,4-Triazolo[1,5-a]pyridine-Based Inhibitor of Janus Kinase 2 for Use in Anticancer Therapy: Discovery of CEP-33779 by Dugan, Benjamin J, Gingrich, Diane E, Mesaros, Eugen F, Milkiewicz, Karen L, Curry, Matthew A, Zulli, Allison L, Dobrzanski, Pawel, Serdikoff, Cynthia, Jan, Mahfuza, Angeles, Thelma S, Albom, Mark S, Mason, Jennifer L, Aimone, Lisa D, Meyer, Sheryl L, Huang, Zeqi, Wells-Knecht, Kevin J, Ator, Mark A, Ruggeri, Bruce A, Dorsey, Bruce D

“…Members of the JAK family of nonreceptor tyrosine kinases play a critical role in the growth and progression of many cancers and in inflammatory diseases. JAK2…”
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Synthesis, Modeling, and In Vitro Activity of (3‘S)-epi-K-252a Analogues. Elucidating the Stereochemical Requirements of the 3‘-Sugar Alcohol on trkA Tyrosine Kinase Activity by GINGRICH, Diane E., YANG, Shi X., GESSNER, George W., ANGELES, Thelma S., HUDKINS, Robert L.

“…Utilizing our recently published semisynthetic approach to the (3'S)-K-252a diastereomer, we report the first synthesis of the (3'R)-10 diastereomer and a set…”
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Synthesis and kinase inhibitory activity of 3'-(S)-epi-K-252a by GINGRICH, Diane E, HUDKINS, Robert L

“…The 3'-epi diastereomer of K-252a was synthesized with the goal of evaluating the stereochemical requirements of the 3'-sugar alcohol on kinase inhibitory…”
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2,7-Disubstituted-pyrrolo[2,1-f][1,2,4]triazines: New Variant of an Old Template and Application to the Discovery of Anaplastic Lymphoma Kinase (ALK) Inhibitors with in Vivo Antitumor Activity by Ott, Gregory R, Wells, Gregory J, Thieu, Tho V, Quail, Matthew R, Lisko, Joseph G, Mesaros, Eugen F, Gingrich, Diane E, Ghose, Arup K, Wan, Weihua, Lu, Lihui, Cheng, Mangeng, Albom, Mark S, Angeles, Thelma S, Huang, Zeqi, Aimone, Lisa D, Ator, Mark A, Ruggeri, Bruce A, Dorsey, Bruce D

“…A novel 2,7-disubstituted-pyrrolo[2,1-f][1,2,4]triazine scaffold has been designed as a new kinase inhibitor platform mimicking the bioactive conformation of…”
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A Novel Preparation of Scalemic N-Methyl-.alpha.-Amino Acids by Dorow, R. L, Gingrich, Diane E

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