Search Results - "Gingrich, Alicia A."

Intratumoral NKp46 + natural killer cells are spatially distanced from T and MHC-I + cells with prognostic implications in soft tissue sarcoma by Cruz, Sylvia M, Sholevar, Cyrus J, Judge, Sean J, Darrow, Morgan A, Iranpur, Khurshid R, Farley, Lauren E, Lammers, Marshall, Razmara, Aryana M, Dunai, Cordelia, Gingrich, Alicia A, Persky, Julia, Mori, Hidetoshi, Thorpe, Steven W, Monjazeb, Arta M, Murphy, William J, Canter, Robert J

“…Soft tissue sarcomas (STS) are rare, heterogenous malignancies with an unmet need for novel immunotherapies. Tumor infiltrating lymphocytes (TILs) have been…”
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Analysis of tumor-infiltrating NK and T cells highlights IL-15 stimulation and TIGIT blockade as a combination immunotherapy strategy for soft tissue sarcomas by Judge, Sean J, Darrow, Morgan A, Thorpe, Steve W, Gingrich, Alicia A, O'Donnell, Edmond F, Bellini, Alyssa R, Sturgill, Ian R, Vick, Logan V, Dunai, Cordelia, Stoffel, Kevin M, Lyu, Yue, Chen, Shuai, Cho, May, Rebhun, Robert B, Monjazeb, Arta M, Murphy, William J, Canter, Robert J

“…PurposeGiven the unmet need for novel immunotherapy in soft tissue sarcoma (STS), we sought to characterize the phenotype and function of intratumoral natural…”
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Hospital utilization and disposition among patients with malignant bowel obstruction: a population-based comparison of surgical to medical management by Bateni, Sarah B, Gingrich, Alicia A, Stewart, Susan L, Meyers, Frederick J, Bold, Richard J, Canter, Robert J

“…Malignant bowel obstruction (MBO) is often a terminal event in end-stage cancer patients. The decision to intervene surgically is complex, given the risk of…”
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The Landscape of Immunotherapy for Retroperitoneal Sarcoma by Gingrich, Alicia A, Nassif, Elise F, Roland, Christina L, Keung, Emily Z

“…Significant multidisciplinary scientific effort has been undertaken to understand the heterogeneous family of neoplasms that comprise soft tissue sarcomas…”
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Blood and tissue biomarker analysis in dogs with osteosarcoma treated with palliative radiation and intra-tumoral autologous natural killer cell transfer by Judge, Sean J, Yanagisawa, Mio, Sturgill, Ian R, Bateni, Sarah B, Gingrich, Alicia A, Foltz, Jennifer A, Lee, Dean A, Modiano, Jaime F, Monjazeb, Arta M, Culp, William T N, Rebhun, Robert B, Murphy, William J, Kent, Michael S, Canter, Robert J

“…We have previously reported radiation-induced sensitization of canine osteosarcoma (OSA) to natural killer (NK) therapy, including results from a first-in-dog…”
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Comparative Immunogenomics of Canine Natural Killer Cells as Immunotherapy Target by Gingrich, Alicia A, Reiter, Taylor E, Judge, Sean J, York, Daniel, Yanagisawa, Mio, Razmara, Aryana, Sturgill, Ian, Basmaci, Ugur Nur, Brady, Rachel V, Stoffel, Kevin, Murphy, William J, Rebhun, Robert B, Brown, C Titus, Canter, Robert J

“…Natural killer (NK) cells are key effectors of the innate immune system, but major differences between human and murine NK cells have impeded translation…”
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Clinical Outcomes and Costs Following Unplanned Excisions of Soft Tissue Sarcomas in the Elderly by Bateni, Sarah B., Gingrich, Alicia A., Jeon, Sun Y., Hoch, Jeffrey S., Thorpe, Steven W., Kirane, Amanda R., Bold, Richard J., Canter, Robert J.

“…Surgical guidelines for soft tissue sarcoma (STS) emphasize pretreatment evaluation and reports of the perils of unplanned excision exist. Given the paucity of…”
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Improved characterization and translation of NK cells for canine immunotherapy by Razmara, Aryana M, Gingrich, Alicia A, Toedebusch, Christine M, Rebhun, Robert B, Murphy, William J, Kent, Michael S, Canter, Robert J

“…The field of cancer immunology has seen a meteoric rise in interest and application due to the discovery of immunotherapies that target immune cells, often…”
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Predictors of Residual Disease after Unplanned Excision of Soft Tissue Sarcomas by Gingrich, Alicia A, Elias, Alexandra, Michael Lee, Chia-Yuan, Nakache, Yves-Paul N, Li, Chin-Shang, Shah, Dhruvil R, Boutin, Robert D, Canter, Robert J

“…Abstract Background Unplanned excision of soft tissue sarcomas (STS) is an important quality of care issue given the morbidity related to tumor bed excision…”
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Human soft tissue sarcomas harbor an intratumoral viral microbiome which is linked with natural killer cell infiltrate and prognosis by Perry, Lauren M, Cruz, Sylvia M, Kleber, Kara T, Judge, Sean J, Darrow, Morgan A, Jones, Louis B, Basmaci, Ugur N, Joshi, Nikhil, Settles, Matthew L, Durbin-Johnson, Blythe P, Gingrich, Alicia A, Monjazeb, Arta Monir, Carr-Ascher, Janai, Thorpe, Steve W, Murphy, William J, Eisen, Jonathan A, Canter, Robert J

“…Groundbreaking studies have linked the gut microbiome with immune homeostasis and antitumor immune responses. Mounting evidence has also demonstrated an…”
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Inhaled recombinant human IL-15 in dogs with naturally occurring pulmonary metastases from osteosarcoma or melanoma: a phase 1 study of clinical activity and correlates of response by Rebhun, Robert B, York, Daniel, Cruz, Sylvia Margret, Judge, Sean J, Razmara, Aryana M, Farley, Lauren E, Brady, Rachel V, Johnson, Eric G, Burton, Jenna H, Willcox, Jennifer, Wittenburg, Luke A, Woolard, Kevin, Dunai, Cordelia, Stewart, Susan L, Sparger, Ellen E, Withers, Sita S, Gingrich, Alicia A, Skorupski, Katherine A, Al-Nadaf, Sami, LeJeune, Amandine T, Culp, William TN, Murphy, William J, Kent, Michael S, Canter, Robert J

“…PurposeAlthough recombinant human interleukin-15 (rhIL-15) has generated much excitement as an immunotherapeutic agent for cancer, activity in human clinical…”
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Role of Radiation Therapy in Adult Extraskeletal Ewing’s Sarcoma Patients Treated with Chemotherapy and Surgery by Thorpe, Steven W., Monjazeb, Arta M., Kirane, Amanda R., Canter, Robert J., Gingrich, Alicia A., Saiz, Augustine M., Randall, R. Lor

“…Radiation therapy (RT) is advocated in the multimodal treatment of high-grade soft tissue sarcoma (STS), but its role may be less clear in…”
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Natural Killer and T Cell Infiltration in Canine Osteosarcoma: Clinical Implications and Translational Relevance by Razmara, Aryana M, Judge, Sean J, Gingrich, Alicia A, Cruz, Sylvia M, Culp, William T N, Kent, Michael S, Rebhun, Robert B, Canter, Robert J

“…Metastatic osteosarcoma has a bleak prognosis in both humans and dogs, and there have been minimal therapeutic advances in recent decades to improve outcomes…”
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Locally Advanced Spiroadenocarcinoma in the Regional Axilla of a Breast Cancer Patient: Hallmarks of Definitive Diagnosis and Management by Gingrich, Alicia A, Fung, Maxwell A, Konia, Thomas, Canter, Robert J

“…Eccrine spiroadenocarcinoma is an extremely rare malignant eccrine gland tumor which may masquerade as other more common malignancies such as poorly…”
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Defining Value for Pancreatic Surgery in Early-Stage Pancreatic Cancer by Bateni, Sarah B, Gingrich, Alicia A, Hoch, Jeffrey S, Canter, Robert J, Bold, Richard J

“…Value-based care is increasingly important, with rising health care costs and advances in cancer treatment leading to greater survival for patients with…”
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Disparities in the Occurrence of Late Effects following Treatment among Adolescent and Young Adult Melanoma Survivors by Gingrich, Alicia A, Sauder, Candice A M, Goldfarb, Melanie, Li, Qian, Wun, Ted, Keegan, Theresa H M

“…Melanoma is the third most common cancer in the adolescent and young adult (AYA) population; however, no studies have addressed the occurrence of adverse…”
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Neoadjuvant Radiotherapy is Associated with R0 Resection and Improved Survival for Patients with Extremity Soft Tissue Sarcoma Undergoing Surgery: A National Cancer Database Analysis by Gingrich, Alicia A., Bateni, Sarah B., Monjazeb, Arta M., Darrow, Morgan A., Thorpe, Steven W., Kirane, Amanda R., Bold, Richard J., Canter, Robert J.

“…Background Neoadjuvant radiotherapy (RT) is increasingly advocated for the management of soft tissue sarcoma (STS). Therefore, this study sought to…”
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Novel Targets in Melanoma: Intralesional and Combination Therapy to Manipulate the Immune Response by Gingrich, Alicia A, Kirane, Amanda R

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Chemotherapy After Diagnosis of Malignant Bowel Obstruction is Associated with Superior Survival for Medicare Patients with Advanced Malignancy by Bateni, Sarah B., Gingrich, Alicia A., Kirane, Amanda R., Sauder, Candice A. M., Gholami, Sepideh, Bold, Richard J., Meyers, Frederick J., Canter, Robert J.

“…Background Although malignant bowel obstruction (MBO) often is a terminal event, systemic therapies are advocated for select patients to extend survival. This…”
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Radiotherapy is Associated With Improved Survival in Patients With Synovial Sarcoma Undergoing Surgery: A National Cancer Database Analysis by Gingrich, Alicia A., Marrufo, Angelica S., Liu, Yu, Li, Chin-Shang, Darrow, Morgan A., Monjazeb, Arta M., Thorpe, Steven W., Canter, Robert J.

“…Previous studies have demonstrated an association of perioperative radiotherapy (RT) with improved survival in patients with synovial sarcoma (SS) undergoing…”
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