Search Results - "Gingras, Stephane"

Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal by Fares, Iman, Chagraoui, Jalila, Gareau, Yves, Gingras, Stéphane, Ruel, Réjean, Mayotte, Nadine, Csaszar, Elizabeth, Knapp, David J. H. F., Miller, Paul, Ngom, Mor, Imren, Suzan, Roy, Denis-Claude, Watts, Kori L., Kiem, Hans-Peter, Herrington, Robert, Iscove, Norman N., Humphries, R. Keith, Eaves, Connie J., Cohen, Sandra, Marinier, Anne, Zandstra, Peter W., Sauvageau, Guy

“…The small number of hematopoietic stem and progenitor cells in cord blood units limits their widespread use in human transplant protocols. We identified a…”
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Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia by Baccelli, Irène, Gareau, Yves, Lehnertz, Bernhard, Gingras, Stéphane, Spinella, Jean-François, Corneau, Sophie, Mayotte, Nadine, Girard, Simon, Frechette, Mélanie, Blouin-Chagnon, Valérie, Leveillé, Koryne, Boivin, Isabel, MacRae, Tara, Krosl, Jana, Thiollier, Clarisse, Lavallée, Vincent-Philippe, Kanshin, Evgeny, Bertomeu, Thierry, Coulombe-Huntington, Jasmin, St-Denis, Corinne, Bordeleau, Marie-Eve, Boucher, Geneviève, Roux, Philippe P., Lemieux, Sébastien, Tyers, Mike, Thibault, Pierre, Hébert, Josée, Marinier, Anne, Sauvageau, Guy

“…To identify therapeutic targets in acute myeloid leukemia (AML), we chemically interrogated 200 sequenced primary specimens. Mubritinib, a known ERBB2…”
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Synthesis of Potent and Orally Efficacious 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor HSD-016 by Wan, Zhao-Kui, Chenail, Eva, Li, Huan-Qiu, Kendall, Christopher, Wang, Youchu, Gingras, Stéphane, Xiang, Jason, Massefski, Walter W, Mansour, Tarek, S, Saiah, Eddine

“…Cortisol and the glucocorticoid receptor (GR) signaling pathway has been linked to the development of diabetes and metabolic syndrome. In vivo,…”
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The Process Development of Ravuconazole: An Efficient Multikilogram Scale Preparation of an Antifungal Agent by Pesti, Jaan, Chen, Chien-Kuang, Spangler, Lori, DelMonte, Albert J, Benoit, Serge, Berglund, Derek, Bien, Jeffrey, Brodfuehrer, Paul, Chan, Yeung, Corbett, Elisabeth, Costello, Carrie, DeMena, Paul, Discordia, Robert P, Doubleday, Wendel, Gao, Zhinong, Gingras, Stephane, Grosso, John, Haas, Oscar, Kacsur, David, Lai, Chiajen, Leung, Simon, Miller, Melanie, Muslehiddinoglu, Jale, Nguyen, Nina, Qiu, Jun, Olzog, Martina, Reiff, Emily, Thoraval, Dominique, Totleben, Michael, Vanyo, Dale, Vemishetti, Purushotham, Wasylak, John, Wei, Chenkou

“…The development of a safe, robust process for the preparation of ravuconazole (1), an antifungal agent, is described. The discovery and development of…”
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Kilogram Synthesis of a Selective Serotonin Reuptake Inhibitor by Anthes, Robert, Bello, Osagie, Benoit, Serge, Chen, Chien-Kuang, Corbett, Elisabeth, Corbett, Richard M, DelMonte, Albert J, Gingras, Stephane, Livingston, Robert, Sausker, Justin, Soumeillant, Maxime

“…Process development of a selective serotonin reuptake inhibitor (1) is described. The synthesis features Nishiyama catalyst-mediated asymmetric…”
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1023 – THE IMPORTANCE OF STEM CELL EXPANSION IN TOMORROW'S MEDICINE by Sauvageau, Guy, Chagraoui, Jalila, Tomellini, Elisa, Rojas-Sutterlin, Shanti, Corneau, Sophie, Girard, Simon, Tellelchea, Maria Florencia, Gingras, Stephane, Gareau, Yves, Ruel, Rejean, Cohen, Sandra, Milano, Filippo, Marinier, Anne

“…UM171 activates a novel E3 ligase complex that mediates the degradation of the CoREST1 complex which includes the demethylase LSD1 and the HDAC1/2…”
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Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of Mitochondrial Vulnerability in Acute Myeloid Leukemia by Baccelli, Irene, Gareau, Yves, Lehnertz, Bernhard, Stephane, Gingras, Spinella, Jean-Francois, Beautrait, Alexandre, Corneau, Sophie, Mayotte, Nadine, Boivin, Isabel, Girard, Simon, MacRae, Tara, Frechette, Melanie, Leveille, Koryne, Krosl, Jana, Thiollier, Clarisse, Kanshin, Evgeny, Bertomeu, Thierry, Coulombe-Huntington, Jasmin, St-Denis, Corinne, Bordeleau, Marie-Eve, Boucher, Geneviève, Roux, Philippe P, Lemieux, Sébastien, Tyers, Mike, Thibault, Pierre, Marinier, Anne, Hébert, Josée, Sauvageau, Guy

“…60% to 70% of Acute Myeloid Leukemia (AML) patients enter complete remission after induction regimen, but the majority relapse within 3 years due to the…”
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UM171 Is a Novel and Potent Agonist Of Human Hematopoietic Stem Cell Renewal by Fares, Iman, Chagraoui, Jalila, Gareau, Yves, Gingras, Stephane, Rjean, Ruel, Csaszar, Elizabeth, Cohen, Sandra, Anne, Marinier, Zandstra, Peter W., Sauvageau, Guy

“…▪ Various combinations of soluble factors have been reported to promote the ex vivo proliferation of human HSCs but few of them are capable of promoting…”
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A diene-transmissive approach to the quassinoid skeleton by Spino, Claude, Hill, Bryan, Dubé, Pascal, Gingras, Stéphane

“…Several tetracyclic molecules were prepared by diene-transmissive Diels–Alder cycloadditions. Control over the stereochemical outcome of the cycloaddition was…”
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Stereoselective Construction of Tetrasubstituted Exocyclic Alkenes from the [4 + 2]-Cycloaddition of Vinylallenes by Spino, Claude, Thibault, Carl, Gingras, Stéphane

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An Improved Synthesis of a Selective Serotonin Reuptake Inhibitor by Anthes, Robert, Benoit, Serge, Chen, Chien-Kuang, Corbett, Elisabeth A, Corbett, Richard M, DelMonte, Albert J, Gingras, Stephane, Livingston, Robert C, Pendri, Yadagiri, Sausker, Justin, Soumeillant, Maxime

“…A practical synthesis of 3-((1S, 2S)-2-dimethylaminomethylcyclopropyl)-1H-indole-5-carbonitrile hydrochloride (1), a selective serotonin reuptake inhibitor…”
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Pyrimido-Indole Derivatives Are Novel Agonists of Human Cord Blood Hematopoietic Stem Cell Self-Renewal by Fares, Iman, Chagaroui, Jalila, Gareau, Yves, Gingras, Stéphane, Mayotte, Nadine, Csaszar, Elizabeth, Kiem, Hans-Peter, Iscove, Norman N., Humphries, R. Keith, Eaves, Connie J., Cohen, Sandra, Marinier, Anne, Zandstra, Peter W., Sauvageau, Guy

“…The widespread use of cord blood (CB) unit in transplantation is limited with low number of long-term hematopoietic stem cells (LT-HSCs) and progenitors…”
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Efforts pour la synthèse du squelette des quassinoïdes utilisant une stratégie de Diels-Alder à diènes transmissibles by Gingras, Stephane

“…Le premier chapitre de cet ouvrage décrit les essais préliminaires tentés dans le but d'obtenir un vinylallène tétrasubstitué précurseur pour sa cycloaddition…”
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Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal by Fares, Iman, Chagraoui, Jalila, Gareau, Yves, Gingras, Stéphane, Ruel, Réjean, Mayotte, Nadine, Csaszar, Elizabeth, Knapp, David J H F, Miller, Paul, Ngom, Mor, Imren, Suzan, Roy, Denis-Claude, Watts, Kori L, Kiem, Hans-Peter, Herrington, Robert, Iscove, Norman N, Humphries, R Keith, Eaves, Connie J, Cohen, Sandra, Marinier, Anne, Zandstra, Peter W, Sauvageau, Guy

“…The small number of hematopoietic stem and progenitor cells in cord blood units limits their widespread use in human transplant protocols. We identified a…”
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