Search Results - "Gingras, Alexandre R."

Kindlin-3 recruitment to the plasma membrane precedes high-affinity β2-integrin and neutrophil arrest from rolling by Wen, Lai, Marki, Alex, Roy, Payel, McArdle, Sara, Sun, Hao, Fan, Zhichao, Gingras, Alexandre R., Ginsberg, Mark H., Ley, Klaus

“…Integrin-mediated neutrophil adhesion starts by arrest from rolling. Activation of integrins involves conformational changes from an inactive, bent…”
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The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin by Gunawan, Merry, Venkatesan, Nandini, Loh, Jia Tong, Wong, Jong Fu, Berger, Heidi, Neo, Wen Hao, Li, Liang Yao Jackson, La Win, Myint Khun, Yau, Yin Hoe, Guo, Tiannan, See, Peter Chi Ee, Yamazaki, Sayuri, Chin, Keh Chuang, Gingras, Alexandre R, Shochat, Susana Geifman, Ng, Lai Guan, Sze, Siu Kwan, Ginhoux, Florent, Su, I-hsin

“…Ezh2 is a protein methylase that epigenetically modifies chromatin. Su and colleagues identify a cytoplasmic role for Ezh2 whereby it controls the…”
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Rap1 binding and a lipid-dependent helix in talin F1 domain promote integrin activation in tandem by Gingras, Alexandre R, Lagarrigue, Frederic, Cuevas, Monica N, Valadez, Andrew J, Zorovich, Marcus, McLaughlin, Wilma, Lopez-Ramirez, Miguel Alejandro, Seban, Nicolas, Ley, Klaus, Kiosses, William B, Ginsberg, Mark H

“…Rap1 GTPases bind effectors, such as RIAM, to enable talin1 to induce integrin activation. In addition, Rap1 binds directly to the talin1 F0 domain (F0);…”
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RIAM and Vinculin Binding to Talin Are Mutually Exclusive and Regulate Adhesion Assembly and Turnover by Goult, Benjamin T., Zacharchenko, Thomas, Bate, Neil, Tsang, Ricky, Hey, Fiona, Gingras, Alexandre R., Elliott, Paul R., Roberts, Gordon C.K., Ballestrem, Christoph, Critchley, David R., Barsukov, Igor L.

“…Talin activates integrins, couples them to F-actin, and recruits vinculin to focal adhesions (FAs). Here, we report the structural characterization of the…”
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Transmission of integrin β7 transmembrane domain topology enables gut lymphoid tissue development by Sun, Hao, Lagarrigue, Frederic, Gingras, Alexandre R, Fan, Zhichao, Ley, Klaus, Ginsberg, Mark H

“…Integrin activation regulates adhesion, extracellular matrix assembly, and cell migration, thereby playing an indispensable role in development and in many…”
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Structural basis of the junctional anchorage of the cerebral cavernous malformations complex by Gingras, Alexandre R, Liu, Jian J, Ginsberg, Mark H

“…The products of genes that cause cerebral cavernous malformations (CCM1/KRIT1, CCM2, and CCM3) physically interact. CCM1/KRIT1 links this complex to…”
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Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: Implications for talin activation by Goult, Benjamin T., Xu, Xiao-Ping, Gingras, Alexandre R., Swift, Mark, Patel, Bipin, Bate, Neil, Kopp, Petra M., Barsukov, Igor L., Critchley, David R., Volkmann, Niels, Hanein, Dorit

“…Talin is a large adaptor protein that activates integrins and couples them to cytoskeletal actin. Talin contains an N-terminal FERM (band 4.1, ezrin, radixin,…”
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IL-2 can signal via chemokine receptors to promote regulatory T cells’ suppressive function by Sun, Hao, Lee, Ho-Sup, Kim, Sarah Hyun-Ji, Fernandes de Lima, Mikhael, Gingras, Alexandre R., Du, Qinyi, McLaughlin, Wilma, Ablack, Jailail, Lopez-Ramirez, Miguel A., Lagarrigue, Frederic, Fan, Zhichao, Chang, John T., VanDyke, Derek, Spangler, Jamie B., Ginsberg, Mark H.

“…Canonical interleukin-2 (IL-2) signaling via the high-affinity CD25-containing IL-2 receptor-Janus kinase (JAK)1,3-signal transducer and activator of…”
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Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation by Girija, Umakhanth Venkatraman, Gingras, Alexandre R., Marshall, Jamie E., Panchal, Roshni, Sheikh, Md. Arif, Gál, Péter, Schwaeble, Wilhelm J., Mitchell, Daniel A., Moody, Peter C. E., Wallis, Russell

“…Complement component C1, the complex that initiates the classical pathway of complement activation, is a 790-kDa assembly formed from the target-recognition…”
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Structural Basis of Dimeric Rasip1 RA Domain Recognition of the Ras Subfamily of GTP-Binding Proteins by Gingras, Alexandre R., Puzon-McLaughlin, Wilma, Bobkov, Andrey A., Ginsberg, Mark H.

“…Ras-interacting protein 1 (Rasip1) is an endothelial-specific Rap1 and Ras effector, important for vascular development and angiogenesis. Here, we report the…”
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The Crystal Structure of Pneumolysin at 2.0 Å Resolution Reveals the Molecular Packing of the Pre-pore Complex by Marshall, Jamie E., Faraj, Bayan H. A., Gingras, Alexandre R., Lonnen, Rana, Sheikh, Md. Arif, El-Mezgueldi, Mohammed, Moody, Peter C. E., Andrew, Peter W., Wallis, Russell

“…Pneumolysin is a cholesterol-dependent cytolysin (CDC) and virulence factor of Streptococcus pneumoniae . It kills cells by forming pores assembled from…”
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Talin contains a C-terminal calpain2 cleavage site important in focal adhesion dynamics by Bate, Neil, Gingras, Alexandre R, Bachir, Alexia, Horwitz, Rick, Ye, Feng, Patel, Bipin, Goult, Benjamin T, Critchley, David R

“…Talin is a large (∼2540 residues) dimeric adaptor protein that associates with the integrin family of cell adhesion molecules in cell-extracellular matrix…”
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Heart of glass anchors Rasip1 at endothelial cell-cell junctions to support vascular integrity by de Kreuk, Bart-Jan, Gingras, Alexandre R, Knight, James Dr, Liu, Jian J, Gingras, Anne-Claude, Ginsberg, Mark H

“…Heart of Glass (HEG1), a transmembrane receptor, and Rasip1, an endothelial-specific Rap1-binding protein, are both essential for cardiovascular development…”
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The structure of the C-terminal actin-binding domain of talin by Gingras, Alexandre R, Bate, Neil, Goult, Benjamin T, Hazelwood, Larnele, Canestrelli, Ilona, Grossmann, J Günter, Liu, HongJun, Putz, Nicholas S M, Roberts, Gordon C K, Volkmann, Niels, Hanein, Dorit, Barsukov, Igor L, Critchley, David R

“…Talin is a large dimeric protein that couples integrins to cytoskeletal actin. Here, we report the structure of the C‐terminal actin‐binding domain of talin,…”
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Molecular basis of sugar recognition by collectin-K1 and the effects of mutations associated with 3MC syndrome by Venkatraman Girija, Umakhanth, Furze, Christopher M, Gingras, Alexandre R, Yoshizaki, Takayuki, Ohtani, Katsuki, Marshall, Jamie E, Wallis, A Katrine, Schwaeble, Wilhelm J, El-Mezgueldi, Mohammed, Mitchell, Daniel A, Moody, Peter C E, Wakamiya, Nobutaka, Wallis, Russell

“…Collectin-K1 (CL-K1, or CL-11) is a multifunctional Ca(2+)-dependent lectin with roles in innate immunity, apoptosis and embryogenesis. It binds to…”
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A mechanism of Rap1-induced stabilization of endothelial cell--cell junctions by Liu, Jian J, Stockton, Rebecca A, Gingras, Alexandre R, Ablooglu, Ararat J, Han, Jaewon, Bobkov, Andrey A, Ginsberg, Mark H

“…Activation of Rap1 small GTPases stabilizes cell--cell junctions, and this activity requires Krev Interaction Trapped gene 1 (KRIT1). Loss of KRIT1 disrupts…”
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The Structure of an Interdomain Complex That Regulates Talin Activity by Goult, Benjamin T., Bate, Neil, Anthis, Nicholas J., Wegener, Kate L., Gingras, Alexandre R., Patel, Bipin, Barsukov, Igor L., Campbell, Iain D., Roberts, Gordon C.K., Critchley, David R.

“…Talin is a large flexible rod-shaped protein that activates the integrin family of cell adhesion molecules and couples them to cytoskeletal actin. It exists in…”
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Structural Basis of Mannan-Binding Lectin Recognition by Its Associated Serine Protease MASP-1: Implications for Complement Activation by Gingras, Alexandre R., Girija, Umakhanth Venkatraman, Keeble, Anthony H., Panchal, Roshni, Mitchell, Daniel A., Moody, Peter C.E., Wallis, Russell

“…Complement activation contributes directly to health and disease. It neutralizes pathogens and stimulates immune processes. Defects lead to immunodeficiency…”
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Biochemical and functional characterization of the interaction between pentraxin 3 and C1q by Nauta, Alma J., Bottazzi, Barbara, Mantovani, Alberto, Salvatori, Giovanni, Kishore, Uday, Schwaeble, Wilhelm J., Gingras, Alexandre R., Tzima, Sotiria, Vivanco, Fernando, Egido, Jesús, Tijsma, Odette, Hack, Erik C., Daha, Mohamed R., Roos, Anja

“…Pentraxin 3 (PTX3) is a recently characterized member of the pentraxin family of acute‐phase proteins produced during inflammation. Classical short pentraxins,…”
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Mapping and Consensus Sequence Identification for Multiple Vinculin Binding Sites within the Talin Rod by Gingras, Alexandre R., Ziegler, Wolfgang H., Frank, Ronald, Barsukov, Igor L., Roberts, Gordon C.K., Critchley, David R., Emsley, Jonas

“…The interaction between the cytoskeletal proteins talin and vinculin plays a key role in integrin-mediated cell adhesion and migration. Three vinculin binding…”
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