Search Results - "Ginger, Michael L."
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Two decades taken at speed: genomics, cell biology, ecology, and evolution of protists
Published in BMC biology (29-12-2023)“…In dynamic scientific fields, two decades can be an eternity, with technical and conceptual advances leading to drastically changed landscapes and paradigms…”
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Kinetoplastid Phylogenomics Reveals the Evolutionary Innovations Associated with the Origins of Parasitism
Published in Current biology (25-01-2016)“…The evolution of parasitism is a recurrent event in the history of life and a core problem in evolutionary biology. Trypanosomatids are important parasites and…”
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Transcriptome, proteome and draft genome of Euglena gracilis
Published in BMC biology (07-02-2019)“…Photosynthetic euglenids are major contributors to fresh water ecosystems. Euglena gracilis in particular has noted metabolic flexibility, reflected by an…”
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Molecular paleontology and complexity in the last eukaryotic common ancestor
Published in Critical reviews in biochemistry and molecular biology (01-07-2013)“…Eukaryogenesis, the origin of the eukaryotic cell, represents one of the fundamental evolutionary transitions in the history of life on earth. This event,…”
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5
Protein moonlighting in parasitic protists
Published in Biochemical Society transactions (01-12-2014)“…Reductive evolution during the adaptation to obligate parasitism and expansions of gene families encoding virulence factors are characteristics evident to…”
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The Genome of Naegleria gruberi Illuminates Early Eukaryotic Versatility
Published in Cell (05-03-2010)“…Genome sequences of diverse free-living protists are essential for understanding eukaryotic evolution and molecular and cell biology. The free-living…”
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Modulation of a cytoskeletal calpain-like protein induces major transitions in trypanosome morphology
Published in The Journal of cell biology (04-08-2014)“…Individual eukaryotic microbes, such as the kinetoplastid parasite Trypanosoma brucei, have a defined size, shape, and form yet transition through life cycle…”
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Farming, slaving and enslavement: histories of endosymbioses during kinetoplastid evolution
Published in Parasitology (01-09-2018)“…Parasitic trypanosomatids diverged from free-living kinetoplastid ancestors several hundred million years ago. These parasites are relatively well known, due…”
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Airyscan Superresolution Microscopy to Study Trypanosomatid Cell Biology
Published in Methods in molecular biology (Clifton, N.J.) (2020)“…The recent introduction by Carl Zeiss Ltd. of the Airyscan detector module for their LSM880 confocal laser-scanning microscope has enabled routine…”
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Divergent Cytochrome c Maturation System in Kinetoplastid Protists
Published in mBio (04-05-2021)“…In eukaryotes, heme attachment through two thioether bonds to mitochondrial cytochromes and is catalyzed by either multisubunit cytochrome maturation system I…”
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Genomics and transcriptomics yields a system-level view of the biology of the pathogen Naegleria fowleri
Published in BMC biology (22-07-2021)“…The opportunistic pathogen Naegleria fowleri establishes infection in the human brain, killing almost invariably within 2 weeks. The amoeba performs piece-meal…”
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Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species
Published in Proceedings of the National Academy of Sciences - PNAS (28-02-2012)“…Antigenic variation enables pathogens to avoid the host immune response by continual switching of surface proteins. The protozoan blood parasite Trypanosoma…”
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Autophagy in parasitic protists: Unique features and drug targets
Published in Molecular and biochemical parasitology (01-06-2011)“…[Display omitted] ► Evolutionarily, autophagy pre-dates the divergence of all eukaryotic lineages. ► Many but not all pathogenic protists contain proteins of…”
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Autophagy in protists
Published in Autophagy (01-02-2011)“…Autophagy is the degradative process by which eukaryotic cells digest their own components using acid hydrolases within the lysosome. Originally thought to…”
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Rewiring and regulation of cross-compartmentalized metabolism in protists
Published in Philosophical transactions of the Royal Society of London. Series B. Biological sciences (12-03-2010)“…Plastid acquisition, endosymbiotic associations, lateral gene transfer, organelle degeneracy or even organelle loss influence metabolic capabilities in many…”
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Euglena International Network (EIN): Driving euglenoid biotechnology for the benefit of a challenged world
Published in Biology open (01-11-2022)“…Euglenoids (Euglenida) are unicellular flagellates possessing exceptionally wide geographical and ecological distribution. Euglenoids combine a…”
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Autophagy in protists: examples of secondary loss, lineage-specific innovations, and the conundrum of remodeling a single mitochondrion
Published in Autophagy (16-08-2009)“…Autophagy describes the process by which eukaryotes selectively and non-selectively target cytoplasm and entire organelles for lysosomal or (in yeast) vacuolar…”
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Delineating transitions during the evolution of specialised peroxisomes: Glycosome formation in kinetoplastid and diplonemid protists
Published in Frontiers in cell and developmental biology (12-09-2022)“…One peculiarity of protists belonging to classes Kinetoplastea and Diplonemea within the phylum Euglenozoa is compartmentalisation of most glycolytic enzymes…”
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Niche metabolism in parasitic protozoa
Published in Philosophical transactions of the Royal Society of London. Series B. Biological sciences (29-01-2006)“…Complete or partial genome sequences have recently become available for several medically and evolutionarily important parasitic protozoa. Through the…”
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Divergence of Erv1-Associated Mitochondrial Import and Export Pathways in Trypanosomes and Anaerobic Protists
Published in Eukaryotic Cell (01-02-2013)“…Classifications Services EC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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