Search Results - "Ginderachter, Jo"

Impeding Macrophage Entry into Hypoxic Tumor Areas by Sema3A/Nrp1 Signaling Blockade Inhibits Angiogenesis and Restores Antitumor Immunity by Casazza, Andrea, Laoui, Damya, Wenes, Mathias, Rizzolio, Sabrina, Bassani, Nicklas, Mambretti, Marco, Deschoemaeker, Sofie, Van Ginderachter, Jo A., Tamagnone, Luca, Mazzone, Massimiliano

“…Recruitment of tumor-associated macrophages (TAMs) into avascular areas sustains tumor progression; however, the underlying guidance mechanisms are unknown…”
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Understanding the glioblastoma immune microenvironment as basis for the development of new immunotherapeutic strategies by Pombo Antunes, Ana Rita, Scheyltjens, Isabelle, Duerinck, Johnny, Neyns, Bart, Movahedi, Kiavash, Van Ginderachter, Jo A

“…Cancer immunotherapy by immune checkpoint blockade has proven its great potential by saving the lives of a proportion of late stage patients with immunogenic…”
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Molecular Profiling Reveals a Tumor-Promoting Phenotype of Monocytes and Macrophages in Human Cancer Progression by Chittezhath, Manesh, Dhillon, Manprit Kaur, Lim, Jyue Yuan, Laoui, Damya, Shalova, Irina N., Teo, Yi Ling, Chen, Jinmiao, Kamaraj, Revathy, Raman, Lata, Lum, Josephine, Thamboo, Thomas Paulraj, Chiong, Edmund, Zolezzi, Francesca, Yang, Henry, Van Ginderachter, Jo A., Poidinger, Michael, Wong, Alvin S.C., Biswas, Subhra K.

“…Monocytes and macrophages are major components of the tumor microenvironment, but their contributions to human cancer are poorly understood. We used molecular…”
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Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines by Murray, Peter J., Allen, Judith E., Biswas, Subhra K., Fisher, Edward A., Gilroy, Derek W., Goerdt, Sergij, Gordon, Siamon, Hamilton, John A., Ivashkiv, Lionel B., Lawrence, Toby, Locati, Massimo, Mantovani, Alberto, Martinez, Fernando O., Mege, Jean-Louis, Mosser, David M., Natoli, Gioacchino, Saeij, Jeroen P., Schultze, Joachim L., Shirey, Kari Ann, Sica, Antonio, Suttles, Jill, Udalova, Irina, van Ginderachter, Jo A., Vogel, Stefanie N., Wynn, Thomas A.

“…Description of macrophage activation is currently contentious and confusing. Like the biblical Tower of Babel, macrophage activation encompasses a panoply of…”
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The Heat Is On: 20-HETE Instructs an Immunosuppressive Phenotype in Cancer-Associated Fibroblasts by Van Ginderachter, Jo A.

“…Immunotherapy of cancer is a burgeoning field of research since the realization that our immune system intrinsically has the capacity to restrict tumor…”
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The Ontogeny and Microenvironmental Regulation of Tumor-Associated Macrophages by Movahedi, Kiavash, Van Ginderachter, Jo A

“…Tumor progression is supported by non-cancerous stromal cells, of which tumor-associated macrophages (TAMs) are prominent constituents. These cells could be…”
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Macrophage Metabolism As Therapeutic Target for Cancer, Atherosclerosis, and Obesity by Geeraerts, Xenia, Bolli, Evangelia, Fendt, Sarah-Maria, Van Ginderachter, Jo A

“…Macrophages are not only essential components of innate immunity that contribute to host defense against infections, but also tumor growth and the maintenance…”
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Tissue-resident versus monocyte-derived macrophages in the tumor microenvironment by Lahmar, Qods, Keirsse, Jiri, Laoui, Damya, Movahedi, Kiavash, Van Overmeire, Eva, Van Ginderachter, Jo A.

“…The tumor-promoting role of macrophages has been firmly established in most cancer types. However, macrophage identity has been a matter of debate, since…”
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Podoplanin-Expressing Macrophages Promote Lymphangiogenesis and Lymphoinvasion in Breast Cancer by Bieniasz-Krzywiec, Paweł, Martín-Pérez, Rosa, Ehling, Manuel, García-Caballero, Melissa, Pinioti, Sotiria, Pretto, Samantha, Kroes, Roel, Aldeni, Chiara, Di Matteo, Mario, Prenen, Hans, Tribulatti, María Virginia, Campetella, Oscar, Smeets, Ann, Noel, Agnes, Floris, Giuseppe, Van Ginderachter, Jo A, Mazzone, Massimiliano

“…Among mammary tumor-infiltrating immune cells, the highest expression of podoplanin (PDPN) is found in a subset of tumor-associated macrophages (TAMs). We…”
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Tumor‐induced myeloid‐derived suppressor cell subsets exert either inhibitory or stimulatory effects on distinct CD8+ T‐cell activation events by Schouppe, Elio, Mommer, Camille, Movahedi, Kiavash, Laoui, Damya, Morias, Yannick, Gysemans, Conny, Luyckx, Ariane, De Baetselier, Patrick, Ginderachter, Jo A.

“…Tumor growth coincides with an accumulation of myeloid‐derived suppressor cells (MDSCs), which exert immune suppression and which consist of two main…”
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Novel insights in the regulation and function of macrophages in the tumor microenvironment by Bolli, Evangelia, Movahedi, Kiavash, Laoui, Damya, Van Ginderachter, Jo A

“…PURPOSE OF REVIEWTumors contain not only cancer cells but also nontransformed types of cells, the stromal cells. A bidirectional interplay exists between…”
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How to measure the immunosuppressive activity of MDSC: assays, problems and potential solutions by Bruger, Annika M., Dorhoi, Anca, Esendagli, Gunes, Barczyk-Kahlert, Katarzyna, van der Bruggen, Pierre, Lipoldova, Marie, Perecko, Tomas, Santibanez, Juan, Saraiva, Margarida, Van Ginderachter, Jo A., Brandau, Sven

“…Myeloid-derived suppressor cells (MDSC) are a heterogeneous group of mononuclear and polymorphonuclear myeloid cells, which are present at very low numbers in…”
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Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell–suppressive activity by Movahedi, Kiavash, Guilliams, Martin, Van den Bossche, Jan, Van den Bergh, Rafael, Gysemans, Conny, Beschin, Alain, De Baetselier, Patrick, Van Ginderachter, Jo A.

“…The induction of CD11b+Gr-1+ myeloid-derived suppressor cells (MDSCs) is an important immune-evading mechanism used by tumors. However, the exact nature and…”
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Differential plasticity and fate of brain-resident and recruited macrophages during the onset and resolution of neuroinflammation by De Vlaminck, Karen, Van Hove, Hannah, Kancheva, Daliya, Scheyltjens, Isabelle, Pombo Antunes, Ana Rita, Bastos, Jonathan, Vara-Perez, Monica, Ali, Leen, Mampay, Myrthe, Deneyer, Lauren, Miranda, Juliana Fabiani, Cai, Ruiyao, Bouwens, Luc, De Bundel, Dimitri, Caljon, Guy, Stijlemans, Benoît, Massie, Ann, Van Ginderachter, Jo A., Vandenbroucke, Roosmarijn E., Movahedi, Kiavash

“…Microglia and border-associated macrophages (BAMs) are brain-resident self-renewing cells. Here, we examined the fate of microglia, BAMs, and recruited…”
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M-CSF and GM-CSF Receptor Signaling Differentially Regulate Monocyte Maturation and Macrophage Polarization in the Tumor Microenvironment by Van Overmeire, Eva, Stijlemans, Benoît, Heymann, Felix, Keirsse, Jiri, Morias, Yannick, Elkrim, Yvon, Brys, Lea, Abels, Chloé, Lahmar, Qods, Ergen, Can, Vereecke, Lars, Tacke, Frank, De Baetselier, Patrick, Van Ginderachter, Jo A, Laoui, Damya

“…Tumors contain a heterogeneous myeloid fraction comprised of discrete MHC-II(hi) and MHC-II(lo) tumor-associated macrophage (TAM) subpopulations that originate…”
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The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity by Laoui, Damya, Keirsse, Jiri, Morias, Yannick, Van Overmeire, Eva, Geeraerts, Xenia, Elkrim, Yvon, Kiss, Mate, Bolli, Evangelia, Lahmar, Qods, Sichien, Dorine, Serneels, Jens, Scott, Charlotte L., Boon, Louis, De Baetselier, Patrick, Mazzone, Massimiliano, Guilliams, Martin, Van Ginderachter, Jo A.

“…Various steady state and inflamed tissues have been shown to contain a heterogeneous DC population consisting of developmentally distinct subsets, including…”
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Acute injury in the peripheral nervous system triggers an alternative macrophage response by Ydens, Elke, Cauwels, Anje, Asselbergh, Bob, Goethals, Sofie, Peeraer, Lieve, Lornet, Guillaume, Almeida-Souza, Leonardo, Van Ginderachter, Jo A, Timmerman, Vincent, Janssens, Sophie

“…The activation of the immune system in neurodegeneration has detrimental as well as beneficial effects. Which aspects of this immune response aggravate the…”
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The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages by Scott, Charlotte L., T’Jonck, Wouter, Martens, Liesbet, Todorov, Helena, Sichien, Dorine, Soen, Bieke, Bonnardel, Johnny, De Prijck, Sofie, Vandamme, Niels, Cannoodt, Robrecht, Saelens, Wouter, Vanneste, Bavo, Toussaint, Wendy, De Bleser, Pieter, Takahashi, Nozomi, Vandenabeele, Peter, Henri, Sandrine, Pridans, Clare, Hume, David A., Lambrecht, Bart N., De Baetselier, Patrick, Milling, Simon W.F., Van Ginderachter, Jo A., Malissen, Bernard, Berx, Geert, Beschin, Alain, Saeys, Yvan, Guilliams, Martin

“…Heterogeneity between different macrophage populations has become a defining feature of this lineage. However, the conserved factors defining macrophages…”
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Different Tumor Microenvironments Contain Functionally Distinct Subsets of Macrophages Derived from Ly6C(high) Monocytes by MOVAHEDI, Kiavash, LAOUI, Damya, VAN GINDERACHTER, Jo A, GYSEMANS, Conny, BAETEN, Martijn, STANGE, Geert, VAN DEN BOSSCHE, Jan, MACK, Matthias, PIPELEERS, Daniel, IN'T VELD, Peter, DE BAETSELIER, Patrick

“…Tumor-associated macrophages (TAM) form a major component of the tumor stroma. However, important concepts such as TAM heterogeneity and the nature of the…”
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Myeloid-derived suppressor cells induce multiple myeloma cell survival by activating the AMPK pathway by De Veirman, Kim, Menu, Eline, Maes, Ken, De Beule, Nathan, De Smedt, Eva, Maes, Anke, Vlummens, Philip, Fostier, Karel, Kassambara, Alboukadel, Moreaux, Jérôme, Van Ginderachter, Jo A., De Bruyne, Elke, Vanderkerken, Karin, Van Valckenborgh, Els

“…Multiple Myeloma (MM) is an incurable malignancy of terminally differentiated plasma cells, which are predominantly localized in the bone marrow…”
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